6/17/2025
The Tang laboratory applies a wide range of approaches such as live-cell imaging, single-cell genomics, and biochemistry to study the mechanisms of complex genome rearrangements in cancers, developmental disorders, and…
6/17/2025
Myeloid cells, including granulocytes and macrophages, play a crucial role in the body's defense against infections. Abnormalities in their functions and maturation cause various diseases. At the Trinh laboratory, we…
6/17/2025
Our research focuses on the molecular mechanisms of mitochondrial calcium transport and signaling. We aim to understand how these mitochondrial processes contribute to cardiovascular and neuronal physiology, as well as…
6/17/2025
Papillomaviruses cause the most common lethal malignancy in women world-wide: cervical cancer. Our laboratory studies the actions of the papillomavirus E6 oncoprotein. By identifying host proteins that associate with E6,…
6/17/2025
Hematopoietic stem cells produce multiple blood cell types and replenish themselves through a self-renewal process. As with all cells, hematopoietic stem cells accumulate somatic mutations with age. While most mutations…
6/17/2025
Our research focus is to understand the structure and function of unusual DNA sequences in living cells, and how these sequences cause genome instability and lead to human diseases. Human…
6/17/2025
The genomic DNA of eukaryotes is packaged into chromatin through a fundamental repeating unit known as the nucleosome. In this chromatin environment, our genomic DNA is constantly exposed to a…
6/17/2025
The primary focus of our work is to develop a fundamental understanding of the mechanisms that govern the formation of multinucleated cell types produced by cell-cell fusion – making one…
6/17/2025
MicroRNAs (miRNAs) are small , non-coding RNAs that post- transcriptionally control gene expression by directing either the degradation or translational repression of target mRNAs. miRNAs potentially regulate as many as…
