6/17/2025
CURRENT PROJECTS: - Using mouse genetics to identify the susceptibility factors that control B cell tolerance, differentiation and survival, leading to autoantibody production. - Defining the mechanisms by which autoimmune susceptibility elicits…
6/17/2025
Structural biology of membrane proteins: Membrane proteins represent about ~25% of all proteins in any given genome carrying out many vital functions (transporters, receptors, channels, etc..). Membrane proteins also represent ~50%…
6/17/2025
The systems biology research in the Fallahi-Sichani lab is focused primarily on understanding the mechanisms through which human cancer cells respond heterogeneously to environmental and therapeutic perturbations. These responses can…
6/17/2025
T cell/Treg therapy; gene immunotherapy; cancer immunotherapy; mammalian target of rapamycin (mTOR)-signaling pathway
6/17/2025
My laboratory, in collaboration with my colleague Dr. Jon Bjarnason, was one of the first to identify and characterize the metalloproteinases present in numerous snake venoms. These Snake Venom Metalloproteinases;…
6/17/2025
Our research program is concerned with the synthesis, properties and applications of metal complexes with polymeric ligands. These multifunctional targets are prepared by combining coordination chemistry with living polymerization methodologies.…
6/17/2025
Our lab is interested in the molecular and cellular basis of human disease, with a focus on aberrant signal transduction of protein kinases in ciliopathies, a class of human diseases…
6/17/2025
We aim to understand how eukaryotic cells control chromatin structure. Knowledge of chromatin-structure at the level of its nucleosome subunits inside cells will give far-reaching mechanistic insight into gene regulation,…
6/17/2025
Acute Myeloid Leukemia (AML) is the most common acute leukemia in adults. AML prognosis and overall survival decline in patients older that 60 years of age and in patients who…
6/17/2025
The goal of my research is to understand the mechanistic underpinnings of the cell signaling network that contribute to cancer progression and resistance to therapy. My laboratory is currently focused…
