6/17/2025
Dr. Le’s research focuses on neural-crest derived tissue development, regeneration and tumorigenesis, in particular the biology of neurofibromatosis. His laboratory investigates how genetic and tumor microenvironmental factors interplay to regulate…
6/17/2025
1. Wnt and PCP signaling in mechanosensory hair cell polarity. The actin-based hair bundle atop sensory hair cells is the mechanotransduction organelle essential for hearing and balance. A majority of sensorineural…
6/17/2025
The major focus of my lab is to understand how the genetic drivers of cancer fuel tumor evolution and to mechanistically define how these genes contribute to various tumor phenotypes.…
6/17/2025
6/17/2025
Tyrosine phosphorylation is a protein modification that can occur during or after translation of a protein.The phosphate addition to a tyrosine residue, regulated by tyrosine kinases and phosphatases, can result…
6/17/2025
Innate immunity provides the first line of defense against pathogens, which is critically important to limit their replication and spread. However, overactivation of innate immunity causes autoimmune diseases and may…
6/17/2025
All the way up to the 20th century, the human genome has been optimized to survive in environments characterized by fluctuations between periods of feast and famine. These survivor-genomes clash…
6/17/2025
The Pani lab pursues curiosity-driven research exploring the cell biological foundations of development and tissue maintenance. Cell-cell signaling performs critical functions in development, homeostasis, and disease. In normal conditions, cell signaling…
6/17/2025
Much of our work focuses on cell signaling and mechanisms of lineage specification, differentiation and morphogenesis. Particular emphases have been on post-embryonic neural crest stem cells and their derivatives, including…
6/17/2025
The overarching goal of our research is functional understanding of molecular alterations in lung cancer. To that end, we determine impacts of genomic and transcriptomic alterations on tumor development and…
