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Research Discipline: Structural Biology

Gan, Lu

6/17/2025

We aim to understand how eukaryotic cells control chromatin structure. Knowledge of chromatin-structure at the level of its nucleosome subunits inside cells will give far-reaching mechanistic insight into gene regulation,…

Ganser-Pornillos, Barbie

6/17/2025

There are two morphologically distinct forms of the HIV-1 virus, called immature and mature. The immature virion is the form that initially assembles and initiates budding from the plasma membrane.…

Jansen, Maurits A.

6/17/2025

Jomaa, Ahmad

6/17/2025

- Quality Control of Protein Targeting to the Endoplasmic Reticulum - Protein Targeting and Import into Mitochondria

Li, Hui

6/17/2025

Targeted therapy: by serendipity, we identified a novel oncogene, and found that multiple cancers are addicted to its activity. This oncogene addiction is evidenced in glioblastoma, pediatric sarcoma, and others.…

Lu, Xiaowei

6/17/2025

1. Wnt and PCP signaling in mechanosensory hair cell polarity. The actin-based hair bundle atop sensory hair cells is the mechanotransduction organelle essential for hearing and balance. A majority of sensorineural…

Minor, Wladek

6/17/2025

Our laboratory studies macromolecular structures with an aim toward an in-depth understanding of structure-function relationships. X-ray diffraction analysis is our primary research tool, but we also employ other physical and…

Naegle, Kristen

6/17/2025

Tyrosine phosphorylation is a protein modification that can occur during or after translation of a protein.The phosphate addition to a tyrosine residue, regulated by tyrosine kinases and phosphatases, can result…

Papin, Jason

6/17/2025

Systems analysis has become a requirement for making sense of high-throughput data and for characterizing properties of biological networks. In order to extend these recent developments to medical applications, there…

Peirce-Cottler, Shayn M.

6/17/2025

The Important Role of the Microcirculation: Every organ in the body is dependent on blood flow to provide the necessary oxygen and nutrients in order to stay alive. The circulatory system…