6/17/2025
Membrane proteins facilitate the transfer of information across lipid bilayers, comprise approximately 25% of a typical proteome, and represent over half of all drug targets. The membrane proteins that mediate…
6/17/2025
Current funded projects in the laboratory: (1) Elucidation of molecular mechanisms controlling smooth muscle contractility; (2) Development of drugs against the influenza and Ebola viruses; (3) Studies of the mechanism of protein crystallization…
6/17/2025
In every human cell, dynamic cytoskeletal networks drive or enable critical processes such as cell division, motility, and secretion. Cytoskeletal dysregulation consequently results in cellular malfunction and several pathologies, ranging…
6/17/2025
Our research is focused on the structure and function of macromolecular assemblies, using the techniques of electron cryo-microscopy and three-dimensional reconstruction. Historically, we have been working in two different areas:…
6/17/2025
Structural biology of membrane proteins: Membrane proteins represent about ~25% of all proteins in any given genome carrying out many vital functions (transporters, receptors, channels, etc..). Membrane proteins also represent ~50%…
6/17/2025
The systems biology research in the Fallahi-Sichani lab is focused primarily on understanding the mechanisms through which human cancer cells respond heterogeneously to environmental and therapeutic perturbations. These responses can…
6/17/2025
They have no symptoms, but subjects with untreated hypertension and salt sensitivity will have major health challenges such as blindness, stroke, kidney failure, and heart attacks. These devastating (and costly)…
6/17/2025
6/17/2025
My laboratory, in collaboration with my colleague Dr. Jon Bjarnason, was one of the first to identify and characterize the metalloproteinases present in numerous snake venoms. These Snake Venom Metalloproteinases;…
6/17/2025
Our lab is interested in the molecular and cellular basis of human disease, with a focus on aberrant signal transduction of protein kinases in ciliopathies, a class of human diseases…
