About

Our Goals
Resource Statement

We encourage users to acknowledge the core in their posters and publications. A resource statement summarizes the capabilities of the core.

See Statement

The mission of the Genome Analysis and Technology Core (GATC)  is to serve as a scientific resource and biotechnology hub enhancing the scope and quality of basic and translational research at UVA, and to provide customer satisfaction, collaboration and quality control.

The goal of the core staff is to enable Next Generation Sequencing projects for both novice and experienced users alike, by providing timely assistance in all facets of experimentation from project design and execution to data analysis and reporting.

Core Acknowledgement

Users are required to acknowledge the Core in their publications. Please add the following to your acknowledgment section:

“This work used (service and/or instrument name) in the Genome Analysis and Technology Core which is supported by the University of Virginia School of Medicine.”

If you are a Cancer Center member and eligible for the CC copay, please use this acknowledgement:

“This work used (service and/or instrument name) in the Genome Analysis and Technology Core, which is supported in part by a Cancer Center Support Grant P30 CA44579-21 from the National Cancer Institute and by core funds from the University of Virginia School of Medicine.”

Meet the Team

Katia Sol-Church, PhD., is the current Director overseeing the activities of the GATC.  Dr. Sol-Church is a Professor in the Department of Pathology, with 19 years of experience in core operation.  She provides mentoring for project design and troubleshooting, coordination for sample processing and for the development of new services supporting Next Generation Sequencing.  Katia  has a long-standing record of successful collaborative research with clinicians and scientists, including early career scientists, leading to the publication of 65 peer reviewed articles and one Book Chapter.   Dr. Sol-Church is a recognized leader in the core community for her work in support of education, research rigor and reproducibility.

Yongde Bao, Ph.D., is Associate Professor of Research with expertise in analytical chemistry and Biotechnology including bioinformatics analysis of gene expression and NGS data set.  Yongde  is a veteran in the lab with 24 years of experience in core operation.  He was instrumental in establishing the first core NGS services at UVa.  Dr. Bao currently lead the daily operation of the GATC sequencing facility located in room 1044 and provides data analysis services and guidance for project design.  Dr. Bao has been active with the core community as a research group member, notably with the Association of Biomolecular Resource Facilities.   He is also ad hoc editor/reviewer for a number of biotechnical journals.

 Alyson Prorock, M.S., leads the daily operation of the GATC preparative lab located in room 1076, and functions as back up to the sequencing core.   Alyson brings to the core a unique set of skills due to her undergraduate training in process engineering and her graduate training in biomedical engineering.  Though her primary responsibility is to execute new workflow for NGS library preparation, she is instrumental at maintaining rigor and reproducibility in all aspects of core services.  Alyson provides guidance and troubleshooting to users and facilitate iLab access to the core services.

Services and Location

Located in Pinn Hall, the core is a fee-for-service facility that offers instrumentation and expertise in all areas of NGS genomics and transcriptomics.   Current applications supported by the core staff include 10x Genomics library preps (including Single Cell (Sc) RNA Seq, ATAC-seq, CNV, VDJ Immune profiling, and Cite-seq with Feature barcoding), bulk RNA Seq, CHIP Seq, ATAC Seq, Amplicon DNA Seq, 16S ribosomal gene sequencing, shot gun sequencing for small genomes and whole exome sequencing (WES).  The core also provides real time and droplet digital PCR services most suitable for targeted gene expression, SNP genotyping and CNV discovery.  GATC provides training for the core shared instrumentation used for nucleic acid analysis.

Coming soon  Nanopore long read DNA and direct RNA sequencing : Bringing the power of ultra-long reads to resolve area of the genome not amicable to short read technology and characterize full length transcripts, isoforms and fusions.

 

More Information

The GATC team also provides multi-core project coordination to streamline project and enhance data output.  We provide student training and education, and support for  grant application including project design, letter of support and budget preparation.