We encourage users to acknowledge the core in their posters and publications. A resource statement summarizes the capabilities of the core.
The DNA Sciences Core has been recently restructured and renamed the Genome Analysis and Technology Core (GATC), to reflect its full genomics core capabilities. The GATC mission is to serve as a scientific resource and biotechnology hub enhancing the scope and quality of basic and translational research at UVA, and to provide customer satisfaction, collaboration and quality control. The goal of the core staff is to enable high throughput (Next Generation) sequencing projects for both novice and experienced users alike, by providing timely assistance in all facets of experimentation from project design/execution to data analysis/reporting.
Katia Sol-Church, PhD., is the Director of the GATC. She is a Research Professor in the Department of Pathology, with 17 years’ experience in core operation. Dr. Sol-Church has a long-standing record of successful collaborative research with clinicians and scientists, including early career scientists, leading to the publication of more than 60 peer reviewed articles. She is a recognized leader in the core community for her work in support of research rigor and reproducibility and core sharing and sustainability. Dr. Sol-Church will work closely with the Faculty Advisor, Dr. Yuh Hwa Wang and Director of Research Infrastructure, Dr. Jay Fox to enhance the core NGS capabilities and develop the core as a scientific resource for UVA investigators.
Yongde Bao, Ph.D., is Associate Professor of Research with expertise in analytical chemistry and Biotechnology including bioinformatics analysis of gene expression and NGS data set. Dr. Bao is a veteran in the lab with 22 years of experience in core operation. He has served as the DNA Sciences Core Director and was instrumental in establishing the first core NGS services at UVA. He has been active with the core community as a research group member, notably with the Association of Biomolecular Resource Facilities. He is also ad hoc editor/reviewer for a number of biotechnical journals. Dr. Bao leads the daily operation of the GATC sequencing facility located in room 1044.
Alyson Prorock, M.S., brings to the core a unique set of skills due to her undergraduate training in process engineering and her graduate training in biomedical engineering. Ms. Prorock leads the daily operation of the GATC preparative lab located in room 1076, as well as run the single cell RNASeq pipeline for the core. Her primary responsibility is to execute new workflow for NGS library preparation, support the sequencing core and facilitate iLab access.
Located in Pinn Hall, the core is a fee-for-service facility that offers instrumentation and expertise in all areas of NGS genomics and transcriptomics. Current applications supported by the core staff include Single Cell (Sc) RNA Seq, bulk RNA Seq, CHIP Seq, ATAC Seq, Amplicon DNA Seq, 16S ribosomal gene sequencing, shot gun sequencing for small genomes and whole exome sequencing (WES). The core also provides real time and droplet digital PCR services most suitable for targeted gene expression, SNP genotyping and CNV discovery. GATC provides training for the core shared instrumentation used for nucleic acid analysis.
The facility also provides tissue samples from remnant surgical resection and autopsy specimens linked to clinicopathologic data while maintaining patient confidentiality; provides Clinical Trial and Clinical Research Support for the collection and processing of blood, other biofluids and tissue specimens; assists in the retrieval of archival histologic slides and tissue samples from the Department of Pathology; offers histology-based research services to support basic, translational and clinical research; and provides expert histopathology support from board-certified Anatomic Pathologists for Core activities.