How to Get Involved in Clinical Research
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Bhiken I. Naik MBBCh, MSCR
Vice Chair of Clinical Research
Welcome to Clinical Research in the Department of Anesthesiology at the University of Virginia led by the Vice Chair Dr. Bhiken Naik, MBBCh, MSCR. Our work is a collaboration amongst physicians, clinical research coordinators, statisticians, bioinformaticist, and data scientists. Our Clinical research spans both prospective clinical studies and retrospective, observational research.
We work across multiple disciplines and specialties to improve patient safety and identify quality improvement opportunities. We create and define objective metrics to evaluate physician performance and provide opportunities for cost effective and reproducible research.
Furthermore, the Division provides data support to administrative systems within the department and the institution. This includes a generation of reports on clinical practice and outcomes, dashboard maintenance at the departmental and institutional levels, and evaluation and benchmarking of educational activities (e.g. case listings for residents) and clinical workload (e.g. call distribution).
Clinical Research Team (Click to Enlarge Image)
Announcements
About
Lauren K. Dunn, MD, PhD
Lauren K. Dunn, MD, PhD
Dr. Dunn is an Associate Professor of Anesthesiology and Neurological Surgery. Her clinical work focuses on the care of patients undergoing craniotomy and complex spine surgery, as well as general anesthesia. Her research interests are analgesia and postoperative pain management, sleep and fatigue and physician well-being.
She is the recipient of a Foundation in Anesthesia Education and Research (FAER) Research in Education Grant studying interventions to improve anesthesiology resident wellness. She is a member of the American Society of Anesthesiologists Committee on Physician Well-being and Committee on Women and serves on the Editorial Boards for Anesthesia & Analgesia and the Journal of Neurosurgical Anesthesiology.
Nabil Elkassabany, MD
Nabil Elkassabany, MD
Dr. Elkassabany is the Vice-Chair of Clinical Operations for the UVA Department of Anesthesiology. He is a Professor of Anesthesiology, specializing in Regional and Acute Pain Medicine. Prior to joining the UVA Anesthesiology Nabil Elkassabany was an Associate Professor in the Department of Anesthesiology and Critical Care at the Perelman School of Medicine, University of Pennsylvania in Philadelphia. He was the Director of the sections of Regional and Orthopedic Anesthesiology. He was also the Director of the Anesthesia Service at the ambulatory surgery facility at Penn Medicine at University City.
Dr. Elkassabany did his undergraduate and medical education at Alexandria University, Egypt. He completed his anesthesia residency training at Cleveland Clinic, Cleveland, Ohio and his regional anesthesia subspecialty training at the University of Florida at Gainesville, Florida. He earned a Master Degree in Clinical Epidemiology and Biostatistics in December 2012 from the Perelman School of Medicine at the University of Pennsylvania and his MBA in December 2021 from the Fox School of Business, Temple University in Philadelphia. Dr. Elkassabany is also the Fellowship Program Director for Regional Anesthesia and Acute Pain Medicine at the University of Pennsylvania.
He was inducted to the Academy of Master Clinicians at the University of Pennsylvania in 2018. His research interest focuses on patients’ outcomes after orthopedic surgery, specifically patients who receive regional anesthesia in different clinical settings. He is especially interested in improving patient outcomes after major joint arthroplasty and defining the value added by regional anesthesia and acute pain medicine to patients’ perioperative experience. Nabil is a member of the Board of Directors for the American Society of Regional Anesthesia and Pain Medicine (ASRA). He also Chairs the Educational Track Subcommittee on Regional Anesthesia and Acute Pain Medicine at the American Society of Anesthesiologists (ASA). Dr. Elkassabany will be starting on July 1st, 2022.
Katherine T. Forkin, MD
Katherine T. Forkin, MD
Dr. Forkin is an Associate Professor of Anesthesiology at the University of Virginia. She specializes in the care of patients undergoing liver transplantation.
Dr. Forkin is an Assistant Program Director for the Department of Anesthesiology Residency Program and directs the Foundations of Anesthesia Month course for incoming residents. She serves on the American Society of Anesthesiologists (ASA) Committees for Patient Blood Management, Transplant Anesthesia, and Women Anesthesiologists.
Read Dr. Forkin’s Full Bio
Link to Dr. Forkin’s Publications
Amanda M. Kleiman, MD
Associate Professor
Amanda M. Kleiman, MD
Dr. Kleiman is an Associate Professor of Anesthesiology at the University of Virginia. Her clinical interest/focus centers on caring for patients undergoing cardiothoracic and major vascular surgery as well as liver transplantation. Her research interests include improvement of the care of cardiothoracic surgical patients, echocardiography, and education research focusing on maximizing the quality of resident and medical student education.
Dr. Kleiman has grant funded research examining sleep disturbance following cardiac surgery and its relationship to delirium and dementia. Her particular education research interests include biases in education, the effect of stress, sleep, and wellness on resident training, and novel education/learning techniques. Outside of work, she enjoys being outside with her friends and golden retriever puppy.
Read Dr. Kleiman’s Full Bio
Link to Dr. Kleiman’s Publications
Lynn R Kohan, MD
Lynn R Kohan, MD, Pain Management Division Chief
Dr. Kohan is a Professor of Anesthesiology and Pain Management in the Department of Anesthesiology at the University of Virginia. Her clinical work encompasses care for patients with a wide range of pain disorders in both the in patient and out patient settings.
Dr. Kohan is American Board of Anesthesiology (ABA) certified in anesthesiology and pain medicine. She serves in leadership positions with the American Society of Regional Anesthesia and Pain Medicine, the Association of Pain Program Directors, The Association of Anesthesiology Specialty Program Directors, the American Academy of Pain Medicine, and the Virginia Pain Society.
In addition, she serves on the editorial boards of several pain journals including Pain Medicine, Anesthesia and Analgesia, Interventional Pain Medicine, Annals of Headache Medicine, and Pain Medicine Case Reports.
Michael Mazzeffi, MD, MPH, FASA
Michael Mazzeffi, MD, MPH, FASA
Dr. Mazzeffi is a cardiothoracic anesthesiologist and critical care physician. He also serves as the Vice Chair for Faculty Affairs and Development in the department of Anesthesiology. He completed medical school at Tulane University, residency at Mt. Sinai School of Medicine, and his fellowships at Emory University.
He has Master’s degrees in Public Health and Clinical Research and maintains an active research program in perioperative outcomes research and blood coagulation. His research has been funded by the Society of Cardiovascular Anesthesiologists and Anesthesia Patient Safety Foundation. He is an active member of the Society of Cardiovascular Anesthesiologists and is chair of its ECMO committee. He is also a fellow of the American Society of Anesthesiologists.
Outside of work he enjoys running, traveling, fly-fishing, and spending time with family.
Bhiken Ishwarlal Naik, MBBCh, MSCR
Bhiken Ishwarlal Naik, MBBCh, MSCR
Dr. Naik is a tenured Professor of Anesthesiology and Neurological Surgery, Associate Medical Director of the Nerancy Neuroscience Intensive Care Unit and the Vice-Chair of Clinical Research for the Department of Anesthesiology.
He is board certified in Anesthesiology, Critical Care and Neurocritical Care through the American Board of Anesthesiology. His clinical practice encompasses patients with neurological diseases in the operating room and intensive care unit. Dr. Naik’s research interests include predictions of postoperative complications, improving data for low-middle-income countries and developing recovery trajectories after surgery using mHealth technology.
Dr. Naik is the Principal Investigator for the Multicenter Perioperative Outcomes Group at UVA and is currently completing his Masters in Clinical Research at the School of Public Health. He serves on multiple national committee’s including the American Society of Anesthesiologist, Society of Neuroscience in Anesthesiology and Critical Care and the North American Spine Society.
Brian Reon, MD, PhD
Brian Reon, MD, PhD
Dr. Reon recently joined the Neuroanesthesia Division as part of the Anesthesiology Faculty. Dr. Reon obtained both an MD, and a PhD in experimental pathology from the University of Virginia, spanning the years 2011-2019. He then pursued his residency in Anesthesiology at the University of Pittsburgh Medical Center, successfully completing it in 2023. In Spring 2024, he will be one of two fellows in the MPOG Outcomes Research Fellowship.
With a strong focus on clinical research, Dr. Reon’s interests lie in exploring the relationship between intraoperative parameters (such as bispectral index, anesthetic concentration, and blood pressure) and postoperative delirium. Additionally, Dr. Reon is interested in leveraging large clinical and genomic datasets to risk stratify patients in perioperative medicine.
Robert H. Thiele, MD
Robert H. Thiele, MD, Critical Care Anesthesia Division Chief
Dr. Thiele is a cardiac anesthesiologist and intensivist (ICU doctor) at UVA. A Professor of Biomedical Engineering, and an engineer by training, he is particularly interested in transesophageal ultrasonography and critical care ultrasound, as well as the use and development of advanced monitoring technology. He is an at-large member of the Board of Directors for the University Physicians Group, in addition to serving on the Finance Committee and Investment Subcommittee.
Read Dr. Thiele’s Full Bio
Link to Dr. Thiele’s Publications
Mohamed Tiouririne, MD
Mohamed Tiouririne, MD
Dr. Tiouririne is a professor in the Department of Anesthesiology at the University of Virginia. He is a trained Obstetrician and Gynecologist, Anesthesiologist and a Critical Care Medicine Doctor. Dr. Tiouririne is considered an expert in Obstetric Anesthesiology and holds a dual appointment with the department of Obstetrics and Gynecology. His interests expand beyond the labor and delivery unit and encompass critical care medicine with a specific interest in maternal critical care.
He is the medical Director of our Surgical Admission Suite and Post Anesthesia Care Unit (PACU). Dr Tiouririne served as the Director of Obstetric Anesthesiology for many years and served as the Co-chair for the establishment of the Society of Obstetric Anesthesia and Perinatology recommendation for ERAS after Cesarean section. He was the recipient of the Dean’s Clinical Excellence Award in 2017.
Read Dr. Tiouririne’s Full Bio
Link to Dr. Tiouririne’s Publications
Zhiyi Zuo, MD, PhD
Zhiyi Zuo, MD, PhD, Executive Vice-Chair
Zhiyi Zuo, M.D., Ph.D., is a physician-scientist and has been a faculty member at the University of Virginia for more than 20 years. He takes care of the full range of neurosurgery patients and patients for other surgeries.
Currently, his research team focuses on two projects: 1) mechanisms of postoperative cognitive dysfunction and delirium, and 2) cerebral vascular remodeling and brain ischemic injury. His research has been funded continuously by extramural funding for more than 20 years and is well cited.
He has been awarded by many professional societies, such as American Society of Anesthesiologists that is the largest anesthesiologist society in the world, for his research work.
Jennifer Phillips RN, CCRC
Clinical Research Manager
Jennifer Phillips, RN, CCRC
Clinical Research Manager
JVP8A@uvahealth.org
Jennifer Phillips is an accomplished Clinical Research Manager in the Department of Anesthesiology at the University of Virginia, where she leads a dynamic team of Clinical Research Coordinators and oversees a diverse portfolio of clinical trials. With over 30 years of experience in clinical research and nursing, she brings deep expertise in managing drug and device trials, including FDA regulatory submissions and protocol development. Her previous leadership in workforce development as Director of Research Workforce Development for the integrated Translational Health Research Institute of Virginia (iTHRIV) reflects her commitment to building research capacity and fostering inclusive, well-trained teams across institutions. A certified clinical research coordinator since 2002, she is widely recognized for her contributions to translational science, educational programming, and collaborative research initiatives.
Siny Tsang, PhD
Biostatistician
Siny Tsang, PhD
Biostatistician
ST2SB@uvahealth.org
Dr. Tsang is the Biostatistician for the Department of Anesthesiology. While her primary role is to perform data analysis and interpretation of results for on-going projects, she also collaborates with research teams throughout the design, planning, and implementation process to help produce high quality statistical deliverables.
Dr. Tsang has extensive experience in a variety of statistical analysis techniques and large datasets. She earned her PhD in Quantitative Psychology from the University of Virginia and completed her post-doctoral training in the Psychiatric Epidemiology Training program at Columbia University. If you would like to specifically consult with her on your clinical research proposal, please first make sure your browser is logged into your virginia.edu account and then proceed to her office hour information here.
Amir Abdel Malek, MS
Data Scientist
Amir Abdel Malek, MS
Data Scientist
AKA5Z@uvahealth.org
Amir Abdel Malek has an MS in Industrial Engineering from the New Jersey Institute of Technology. He has spent most of his 25-year career in the healthcare industry, specializing in process improvement, clinical and administrative data analytics, and data mining. As a Data Scientist at the University of Virginia, he leverages big data in support of research and operational initiatives in the perioperative arena.
Ryan Folks, MS
Data Scientist
Ryan Folks, MS
Data Scientist and Machine Learning Engineer
VCZ2AJ@uvahealth.org
Ryan Folks is a data scientist and machine learning engineer for the Department of Anesthesiology at the University of Virginia. Ryan received his bachelors of science in mathematics from James Madison University in 2021 and his masters in data science from the University of Virginia in 2022.
Ryan specializes in computer vision and deep neural networks, and is interested in global health research, predictive modeling for postoperative outcomes, as well as learning about new machine learning techniques like transformers, functional data analysis, and machine learning on graphs.
Emily Chuang, MA
Research Executive Assistant
qgz2tk@uvahealth.org
Lucas Fernandez, DSc
Clinical Research Coordinator
lgf5k@uvahealth.org
Angela Piñeros, MD
Clinical Research Coordinator
acp3k@uvahealth.org
Avani Jain, MD
Clinical Research Coordinator
xnj5vz@uvahealth.org
Lexi Moruza, BS
Clinical Research Coordinator
am2jt@uvahealth.org
Shayan Zakir, MD
Clinical Research Coordinator
rue9hh@uvahealth.org
Sierra Clark
Clinical Research Coordinator
sbc5h@uvahealth.org
Ruch Poudyal
Clinical Research Coordinator
yqy3hg@uvahealth.org
Emily Degen
Clinical Research Coordinator
xpq8ej@uvahealth.org
Hailey Russo
Clinical Research Coordinator
sxu9rn@uvahealth.org
Clinical Research is Actively Supported by the Following Grants:
“Bundle of Love: The effect of self-CARE (Compassion Appreciation Rest and Exercise) on anesthesiology resident wellness” GR014108 GF11096-167460-101, 7/1/2021-6/30/2023
PI: Lauren K Dunn
Non Profit: Foundation for Anesthesia Education and Research
“Smartphone Artificial” GR100450, 9/1/2022-7/31/2023
PI: Bhiken Ishwarlal Naik
Non Profit: Meridian Institute
“Evaluation of the Clinical Performance of the Quantra® System with the QStat® Cartridge in Trauma and Liver Transplantation” GR015881 GI15650-165551-101, 8/27/2020-8/26/2023
PI: Katherine Trumbull Forkin
Industry: HemoSonics, LLC
“An Instrument to Assess the Functional Impact of Chronic Pain Phase II” GR016240 GI16039-169651-101, 10/1/2021-8/31/2023
PI: Lynn R Kohan
Industry: Barron Associates, Inc.
“Discrete Wavelength Frequency Domain Near Infrared Spectroscopy for Non-Invasive Measurement of Cytochrome Oxidation State” GR013755 GB11038-168494-101, 9/21/2021-9/20/2024
PI: Robert Thiele
Federal Government: U.S. NIH Institute of Biomedical Imaging & Bioengineering
“Gut microbiome R21” GR101212, 2/1/2023-1/31/2025
PI: Zhiyi Zuo
Federal Government: U.S. NIH Institute on Aging
“Sedana INSPiRE-ICU1” GR100353, 8/15/2022-8/14/2027
PI: Danny J Theodore
Foreign Industry: Sedana Medical AB
University of Virginia Faculty Select Publications List
January 2025 – May 2025
1. New Kids on the Block: Development and Assessment of a Multispecialty Fascia Iliaca Block Protocol and Training Program for Geriatric Hip Fracture in the Emergency Department.
Kramer JA, Shepherd C, Hess-Homeier D, Ochroch J, Mehta S, Baraniecki-Zwil G, Shofer FS, Elkassabany N, Hussain S, Panebianco N.
Cureus. 2025 Mar 14;17(3):e80560. doi: 10.7759/cureus.80560. PMID: 40225455; PMCID: PMC11994045.
2. What Came First-The Pathology or the Pain?
D’Souza RS, Kohan L, Nelson AM.
Anesth Analg. 2025 Jan 14. doi: 10.1213/ANE.0000000000007275. Epub ahead of print. PMID: 39808727.
3. Pudendal Neuralgia: A Review of the Current Literature
Conic RRZ, Kaur P, Kohan LR.
Curr Pain Headache Rep. 2025 Jan 28;29(1):38. doi: 10.1007/s11916-024-01354-z. PMID: 39873912.
4. Enhancing Early Career Development in Pain Medicine: the Comprehensive Role of Mentorship
Eshraghi Y, Barad M, Pritzlaff S, Emerick T, Wahezi S, Anitescu M, Kohan L.
Pain Med. 2025 Mar 1;26(3):129-130. doi: 10.1093/pm/pnae128. PMID: 39689028.
5. Editorial Review of Qualitative and Quantitative Characteristics of the Lumbar Multifidus Muscles: Comparison of the Magnetic Resonance Imaging and Musculoskeletal Ultrasound
Kohan L.
Interv Pain Med. 2025 Mar 10;4(1):100555. doi: 10.1016/j.inpm.2025.100555. PMID: 40129772; PMCID: PMC11931377.
6. Notable Concerns in Methodology and Conclusions of the Wang et al. Meta-Analysis in BMJ by the American Academy of Pain Medicine.
Schuster NM, Broachwala M, Ahadian FM, Argoff CE, Cohen SP, Durbhakula S, Gulati A, Hurley RW, Kohan L, McCormick ZL, Wahezi SE, Barreveld AM. Pain Med. 2025 Mar 28:pnaf036. doi: 10.1093/pm/pnaf036. Epub ahead of print. PMID: 40156125.
7. Perioperative Lung Expansion and Pulmonary Outcomes After Abdominal Surgery
Blank RS, Ahn HJ.
Lancet Respir Med. 2025 Feb 24:S2213-2600(25)00053-0. doi: 10.1016/S2213-2600(25)00053-0. Epub ahead of print. PMID: 40020693.
8. Protamine Dosing in Cardiac Surgery: Can One Size Fit All?
Mazzeffi M, Levy JH.
Anesthesiology. 2025 Jan 1;142(1):9-11. doi: 10.1097/ALN.0000000000005237. PMID: 39655986.
9. Platelet P2Y12 Receptor Inhibition and Perioperative Patient Management
Mazzeffi M, Tanaka KA, Gurbel PA, Tantry US, Levy JH.
Anesthesiology. 2025 Jan 1;142(1):202-216. doi: 10.1097/ALN.0000000000005148. PMID: 39392789.
10. Fibrinogen Replacement in Neonatal Cardiac Surgery: Methodological Challenges
Butt AL, Mazzeffi MA, Mishima Y, Tanaka KA.
Anesth Analg. 2025 Feb 4. doi: 10.1213/ANE.0000000000007377. Epub ahead of print. PMID: 39903674.
11. Ideal Timing of Coronary Artery Bypass Grafting After Non-ST-Segment Elevation Myocardial Infarction
Norman AV, Weber MP, El Moheb M, Wisniewski AM, Strobel RJ, Speir A, Mazzeffi M, Manchikalapudi A, Joseph M, Tang D, Singh R, Quader M, Beller JP, Yount K, Teman NR.
Ann Thorac Surg. 2025 Feb 11:S0003-4975(25)00113-4. doi: 10.1016/j.athoracsur.2025.01.024. Epub ahead of print. PMID: 39947308.
12. Optimizing Perioperative Extracorporeal Cardiopulmonary Resuscitation Outcomes: Activate Early and Select Carefully
Mazzeffi M, Zaaqoq A, Teman N.
Anesthesiology. 2025 Mar 1;142(3):440-442. doi: 10.1097/ALN.0000000000005323. Epub 2025 Feb 11. PMID: 39932344.
13. Inspired Oxygen Concentration During the Re-initiation of Two-Lung Ventilation in Thoracic Surgery: A Post Hoc Analysis of Data from the Multicenter Perioperative Outcomes Group
Douville NJ, Mathis M, Smolkin ME, Martin LW, Popescu WM, Blank RS.
Anesth Analg. 2025 Mar 10. doi: 10.1213/ANE.0000000000007479. Epub ahead of print. PMID: 40063506.
14. In Vitro Procoagulant Effects of Gla-domainless Factor Xa in Factor XI-deficient and Factor IX-deficient Plasma
Mishima Y, Okada H, Butt AL, Stewart KE, Mazzeffi MA, Tanaka KA.
Thromb Res. 2025 Mar;247:109286. doi: 10.1016/j.thromres.2025.109286. Epub 2025 Feb 15. PMID: 39970742.
15. Cesarean Delivery Outcomes for Patients with Coronavirus Disease-2019 in the USA
Mazzeffi M, Miller D, Garneau A, Sheeran J, Kleiman A, Mehta SH, Tiouririne M.
J Racial Ethn Health Disparities. 2025 Feb;12(1):128-133. doi: 10.1007/s40615-023-01857-2. Epub 2023 Nov 8. PMID: 37938434.
16. Environmental Sustainability in ICUs: A Report From the Society of Critical Care Medicine Sustainability Task Force
Domico M, Meyer MJ, Blackburn L, Toomey SA, Gooch ME, Nadkarni VM, Huckleberry Y, Draper A, Palmieri TL, Nazer LH, Nader A, Valcin EK, Evans S, Al-Hakim T, Murthy S.
Crit Care Med. 2025 Mar 1;53(3):e632-e644. doi: 10.1097/CCM.0000000000006581. Epub 2025 Feb 21. PMID: 39982135.
17. Building an Inclusive Practice within Regional Anesthesia and Acute Pain Medicine
Muse IO, Sabra J, Umeh UO, Elkassabany N.
Anesthesiol Clin. 2025 March; In Press.
18. In Response
Lele AV, Vail EA, O’Reilly-Shah VN, deGrauw X, Domino KB, Walters AM, Fong CT, Gomez C, Naik BI, Mori M, Schonberger R, Deshpande R, Freundlich RE, Mathis MR, Mhyre J, Souter MJ.
Anesth Analg. 2025 Mar 25. doi: 10.1213/ANE.0000000000007503. Epub ahead of print. PMID: 40131819.
19. Formulation of Quality Improvement Methodology for Risk Mitigation in Congenital Cardiac Catheterization
Yeh MJ, Bjornlund E, Gauvreau K, Ali F, Aslam N, Batlivala SP, Berman D, Bocks ML, Chenault K, Doyle T, Gudausky T, Hainstock M, Holzer R, Ibla J, O’Byrne ML, Quinn BP, Shahanavaz S, Sharma R, Trucco SM, Whiteside W, Bergersen L, Armstrong AK.
Pediatr Cardiol. 2025 Jan 14. doi: 10.1007/s00246-024-03738-9. Epub ahead of print. PMID: 39808318.
20. Requesting a Seat at the Table: Fibrin Stabilizing Factor
Sharma R.
Anesth Analg. 2025 Feb 7. doi: 10.1213/ANE.0000000000007413. Epub ahead of print. PMID: 39918995.
21. First-in-human Experience Performing High-resolution Cortical Mapping Using a Novel Microelectrode Array Containing 1024 Electrodes
Konrad P, Gelman KR, Lawrence J, Bhatia S, Jacqueline D, Sharma R, Ho E, Byun YW, Mermel CH, Rapoport BI.
J Neural Eng. 2025 Mar 7;22(2). doi: 10.1088/1741-2552/adaeed. PMID: 39870041.
22. Resigned but Resilient: Caregiver Perceptions of Role Ambiguity and Quality of Care During Hospital-to-Home Transitions of Older Latinos Living with Dementia
Greyson S, Keita M, Sharma R, Yasar S, Boyd C, Keller S, Gurses A, Samus Q, Arbaje A.
J Aging Health. 2025 Mar;37(3-4_suppl):66S-75S. doi: 10.1177/08982643241309443. Epub 2025 Mar 23. PMID: 40123182.
23. Diffuse Myalgia and Neuropathic Pain After COVID Vaccine
Pressler MP, Yaras R, Kohan LR, Singla P.
Pain Med. 2025 Jan 1;26(1):43-44. doi: 10.1093/pm/pnae096. PMID: 39302691.
24. ‘Pain as regional anaesthesia wears off’ or ‘rebound pain’: what’s in a name?
Singla P, Ye Y, Elkassabany NM, Mariano ER.
Anaesthesia. 2025 Mar 3. doi: 10.1111/anae.16583. Epub ahead of print. PMID: 40032279.
25. The Family Anesthesia Experience (FAX): Implementing a Social Support-Focused Wellness Programme Across Multiple Residency Programmes
Martinelli SM, Tran TN, Canter C, Isaak RS, Afroze F, Mulaikal TA, Ladlie B, Jain A, Willie C, Stahl DL, Blanchard E, Zisblatt L, Hoefnagel AL, Marshall JM, Collins S, Keneally RJ, Martin TW, Chen F.
Clin Teach. 2025 Feb;22(1):e13853. doi: 10.1111/tct.13853. PMID: 39710581.
26. Lung Injury in Myocardial Infarction-associated Cardiogenic Shock Supported by Venoarterial Extracorporeal Membrane Oxygenation: A Scoping Review
Zaaqoq AM, Mazzeffi MA, Vogelsong MA, Roeser M, Cho SM.
BMC Cardiovasc Disord. 2025 Jan 23;25(1):40. doi: 10.1186/s12872-025-04472-7. PMID: 39849351; PMCID: PMC11756158.
27. ECMO for the Pregnant and Peripartum Patient: A Practical Review of Indications, Unique Management Considerations, and an Approach Framework.
Hrymak CS, Labib A, Akkanti B, Antonini MV, Bruggeman B, Griffee MJ, Heinsar S, Jacobs JP, Larzelere M, Naoum E, O’Neil E, Roussos-Ross D, Zaaqoq AM, Peek GJ, Arora RC.
Perfusion. 2025 Feb 23:2676591251321070. doi: 10.1177/02676591251321070. Epub ahead of print. PMID: 39988458.
28. Level of Sedation in Patients With COVID-19 Supported With ECMO: A Comparative Analysis of the Critical Care Consortium International Database
Heinsar S, Labib A, Cespedes M, Riera J, White N, Zaaqoq A, Jacobs JP, Buscher H, Alexander PMA, Ciullo A, Aftab M, Suen JY, Bassi GL, Lorusso R, Fraser JF, Peek G; COVID-19 Critical Care Consortium (COVID Critical).
Perfusion. 2025 Feb 26:2676591251324136. doi: 10.1177/02676591251324136. Epub ahead of print. PMID: 40009712.
29. A Retrospective Cohort Study of the Role of Palliative Care Consultation for Patients on Extracorporeal Membrane Oxygenation
Teeri S, Singh P, Gadodia R, Kapil S, Hockstein M, Balsara K, Zaaqoq AM, Rao A.
J Intensive Care Med. 2025 Mar 23:8850666251327105. doi: 10.1177/08850666251327105. Epub ahead of print. PMID: 40123222.
30. Living Alone Predicts Non-Home Discharge Post Elective Hip Arthroplasty: A Matched-pair Cohort Study
Agnor BK, Knio ZO, Zuo Z.
PLoS One. 2025 Jan 2;20(1):e0316024. doi: 10.1371/journal.pone.0316024. PMID: 39746111; PMCID: PMC11694960.
31. Chronic High Fat Diet-induced Cerebrovascular Remodeling Impairs Recovery Of Blood Flow After Cerebral Ischemia In Mice
Li J, Sun N, Hu S, Zuo Z.
J Cereb Blood Flow Metab. 2025 Jan 17:271678X251313723. doi: 10.1177/0271678X251313723. Epub ahead of print. PMID: 39819094; PMCID: PMC11748376.
32. Carboxyl Terminal Modulator Protein Induces Cell Senescence and Is Upregulated with Aging by Zic2 in Rats
Shan W, Li J, Philpot Z, Zuo Z.
J Cell Physiol. 2025 Jan;240(1):e70007. doi: 10.1002/jcp.70007. PMID: 39888066; PMCID: PMC11780686.
33. Pyrrolidine Dithiocarbamate Ameliorates Sepsis-Associated Encephalopathy by Inhibiting Autophagy and Inflammation in the Brain
Lu Y, Zuo Z.
Neurochem Res. 2025 Feb 27;50(2):106. doi: 10.1007/s11064-025-04355-5. PMID: 40011296; PMCID: PMC11865106.
34. Auditory Fear Memory Retrieval Requires BLA-LS And LS-VMH Circuitries Via Gabaergic and Dopaminergic Neurons
Chen M, Li J, Shan W, Yang J, Zuo Z.
EMBO Rep. 2025 Apr;26(7):1816-1834. doi: 10.1038/s44319-025-00403-x. Epub 2025 Mar 7. PMID: 40055468; PMCID: PMC11977213.
35. Are we ready to apply preconditioning-induced neuroprotection to improve the outcome of patients with brain ischemia?
Ren X, Zuo Z.
Translation Medicine Research, In press.
Through the Multicenter Perioperative Outcome Group (MPOG) we collaborate with multiple institutions world-wide to aggregate millions of cases and billions of data points, which create unparalleled opportunities for both research and quality improvement.
Recent projects performed with the MPOG Group include: understanding intraoperative opioid dosing, postoperative respiratory complications, and extubation rates after intracranial surgery.
Research Workflow
Research Project Proposal Workflow
- Generate a Research Idea
- Find a Faculty Mentor or a Clinical Research Committee member.
- Fill out a Preliminary Proposal Form (at least 1 week prior to the scheduled monthly research meeting if one chooses to present it at the meeting) and receive a copy of your response and your REDCap Survey Queue link in your email.
- Present and Discuss Proposed Research at the Monthly Research Meeting for Feedback (Optional)
- Determine to Proceed with the Proposed Research
- Proceed to fill out a Full Clinical Research Proposal by using the REDCap Survey Queue Link in the preliminary form submission confirmation email.
- Consult with the Data Scientist(s) (Optional)
- If the proposed research is investigator-initiated, please discuss the statistical and power analysis with the data scientist(s) for a well-rounded data analysis plan.
- Determine Needs for Additional Departmental Support
- Fill out a Research Coordinator Request Form and, if applicable, Perioperative Database Request Form in the REDCap Survey Queue.
- If requested, the Clinical Research Admin Team will assign IRB Coordinator, CRC(s), and/or Research Assistants accordingly.
- Work on Review Committee Application(s)
- Discuss with the study team (data scientist, CRCs, RAs, and/or IRB Coordinator) to finalize the study’s protocol for IRB and if applicable other review committees’ application submissions.
- Copy and paste your study’s information from your proposal forms to the application forms when applicable.
- Upon Approvals from the Applicable Review Committee(s), Open the Study for Enrollment/Data Collection
- If requested in the proposal, the departmental data scientist will gather and share the specified perioperative database for the proposed study.
- Regularly check in with the study team regarding enrollment/data collection or analysis progress.
- Please kindly note that each study may require reviews from various boards/agencies depending on what the proposed study entails, and this general workflow instruction is mainly to guide you on creating a proposal for the research admin team to review before further proceeding with obtaining all approvals necessary to begin your proposed study.
For questions, email Dr. Bhiken Naik, Dr. Keita Ikeda, or Emily Chuang, MA.
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- Generate a quality improvement idea
- Determine if additional research support is needed for the project
- If research support is needed, fill out a Preliminary Proposal Form
- Please do so at least 1 week prior to a Monthly Research Meeting
Please kindly note that depending on the project’s priority, the number of projects in queue, and the complexity of the research support needed, the completion time will differ.
For questions related to research support, please email Dr. Bhiken Naik, Dr. Keita Ikeda, and/or Emily Chuang, MA.
For questions related to QI projects, please email Khaing Phoo and/or Dr. Sunny Chiao.
What is it?
Every month, the department hosts this meeting to talk about research ideas. Studies include prospective, retrospective, observational or multicenter ones. Discussions span from brainstorming ideas to reviewing and finalizing research proposals.
Who is it for?
Anyone interested in research in anesthesiology! We would love to hear your ideas, feedback, and/or questions. Members of the research committee, clinical research coordinators, data scientist, biostatistician and research administrative staff are available to brainstorm ideas with you.
What research ideas will we discuss this time? / What was discussed in a prior meeting?
Please view our agenda and minutes here for the most up-to-date information (link updated 1/23/2024).
What if I have a research idea that I want to discuss?
Great! Please fill out a preliminary proposal down in the Research Forms Section at least 48 hours before the meeting in which you would like to present your proposal.
For more general information on clinical research workflow, please refer to the Research Workflow Section.
When/Where is it?
The meeting will take place once a month on Wednesdays from 12:00pm-1:00pm in OR Classroom A.
If you are not sure how to get there, please email Emily Chuang, M.A. beforehand.
For those who would like to attend virtually, please refer to Zoom link embedded in the department’s Weekly Lecture Schedule email or in the Anesthesiology MASTER Calendar available on Intranet.
Research Forms
- Preliminary Proposal Form for QI or Research (subsequent proposal form links will be emailed upon submission)
- Research Reporting Guidelines Checklist
- Clinical Research Student Assistant Request
How To Get Involved
We welcome inquiries from Medical Students, Residents, and Fellows interested in participating in our department’s research. Please fill out the Interest Form for Clinical Research Involvement, and upon completion, email Emily Chuang, MA.
Contact Us
Emily Chuang, MA
Research Executive Assistant