6/17/2025
The Purow laboratory is dedicated to developing innovative approaches to treating not only brain tumors but cancer as a whole. We have focused now and in recent years on the following…
6/17/2025
1. Detection of genomic variation: I have developed several methods to identify and map variants (SNPs, indels, and large-scale rearrangements) from large-scale sequencing datasets. This includes identification and genotyping of…
6/17/2025
Our research on viruses provides insight not only into the diseases they cause, but it also leads to the discovery of novel basic mechanisms that operate in eukaryotic cells. Over…
6/17/2025
Dr. Rich's research is centered on understanding the genetic epidemiology of complex human disease, including the genes contributing to atherosclerosis, stroke and intermediate phenotypes (risk factors). These studies range from…
6/17/2025
Cell signaling networks coordinate a wide variety of cellular physiology and gene regulatory programs. Perturbations in these signaling networks contribute to the pathogenesis of many diseases, including cardiovascular disease, cancer…
6/17/2025
My research is at the interface of computation and biology, drawing on techniques in computer science, data science, bioinformatics, and statistics, and applying them to biological questions in cancer, epigenetics,…
6/17/2025
The post-genomic era is marked by the development of technologies which have revealed the astonishing molecular diversity of gene products. Multiple distinct protein forms, or “proteoforms”, can arise through several…
6/17/2025
My primary research interest is in atherosclerosis, which is the cause of heart attack, stroke and peripheral arterial disease. Although mortality from atherosclerosis has had a decline in past few…
6/17/2025
Repair of the stereocilia actin core (project leader: Elizabeth Wagner) Hair bundles are complex structures that have to be maintained throughout the life of the organism, because mature mammalian hair cells…
6/17/2025
Transcriptional silencing Understanding how chromatin structure influences DNA-mediated processes has become a fundamental problem in cellular biology. Chromatin is known to influence the regulation of eukaryotic gene expression, DNA replication, DNA…
