Petri Lab
William A. Petri, Jr., MD, PhD
PRIMARY APPOINTMENT:
Wade Hampton Frost Professor of Medicine and Vice Chair for Research of the Department of Medicine, and Professor of Medicine, Microbiology, Immunology and Cancer Biology, and Pathology, Medicine: Infectious Diseases and International Health, Medicine: Infectious Diseases and International Health
CONTACT:
Division of Infectious Diseases
345 Crispell Drive, MR-6 1st floor, Room 1709
Charlottesville, VA 22908
Telephone: 434-924-5621
Fax: 434-924-0075
Email: wap3g@virginia.edu
EDUCATION AND TRAINING:
- PhD, Microbiology, University of Virginia
- MD, University of Virginia
- Residency, Internal Medicine, University Hospital of Cleveland
- Clinical Fellowship, Infectious Diseases, University of Virginia
Current Laboratory Members
-
William Petri, Jr., MD, PhD
Wade Hampton Frost Professor of Medicine, Infectious Diseases and International Health
Vice Chair for Research, Department of Medicine
Secondary Appointments in Microbiology, Immunology, & Cancer Biology and Pathology
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Mayuresh Abhyankar, PhD
Associate Professor of Research, Infectious Diseases and International Health
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Stacey Burgess, PhD
Assistant Professor of Medicine, Infectious Diseases and International Health
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Carol Gilchrist, PhD
Associate Professor, Infectious Diseases and International Health
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Chelsea Marie, PhD
Associate Professor, Infectious Diseases and International Health
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Brett Moreau, PhD
Research Assistant Professor, Infectious Diseases and International Health
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Girija Ramakrishnan, PhD
Associate Professor, Infectious Diseases and International Health
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Savannah Brovero
Lab and Research Technician
Burgess Lab
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Audrey Brown, PhD
Research Associate
Petri Lab
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Nicholas Hagspiel
Lab and Research Technician
Abhyankar Lab
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Ning-Jiun Jan, PhD
Research Scientist
Marie Lab
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Farha Naz, PhD
Research Associate
Petri Lab
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William Petri
Lab and Research Technician
Petri Lab
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Jashim Uddin, PhD
Research Associate
Petri Lab
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Feifan Xu
Lab and Research Technician
Abhyankar Lab
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Mary Young
Clinical Research Coordinator
Petri Lab
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Rachel Boone
Petri Lab
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Duncan Hart
Petri Lab
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Nick Natale
Petri Lab
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Brandon Thompson
Burgess Lab
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David Tyus
Petri Lab
Lab Research
RESEARCH AREAS
- Biotechnology, Immunology, Infectious Diseases/Biodefense
- Immune mechanisms of defense against COVID-19 and enteric (diarrheal) infections
RESEARCH SUMMARY
William A. Petri, Jr., M.D., Ph.D. studies immunology and molecular pathogenesis of infectious diseases and their consequences. The scope of the research includes immunopathogenesis and vaccine development for COVID-19, molecular parasitology of Entamoeba, innate immune host defense against Clostridium difficile, and in Bangladesh, acquired immunity to Cryptosporidium. We study infections in mouse models, in humans (including clinical trials), and at the lab bench.
COVID-19: We have discovered in patients at the UVA Hospital that an over-active immune system is associated with deterioration to respiratory failure and death and are exploring novel immunotherapy in the mouse model. We also use novel toll-like receptor agonists in a subunit vaccine designed to promote mucosal immunity.
AMEBIASIS: Focusing on amebic colitis, his lab identified the Gal/GalNAc-binding lectin of the parasite Entamoeba histolytica that mediates contact-dependent killing of host cells. Cell biologic studies of adherence, apoptosis, and endocytosis of human cells by the parasite are active areas of investigation. An R01 supports this work to Dr. Petri from the NIH. DNA transformation of the parasite was pioneered in the lab and is used to study molecular pathogenesis. Clinically, the group has developed FDA-approved antigen-detection tests that allow sensitive and specific diagnosis of amebiasis. Current work is focused on the mechanism of Entamoeba killing of host cells by a unique process called trogocytosis (Ralston KD et al., Nature (2014) 508:526) and the development of an amebiasis vaccine in partnership with the Infectious Diseases Research Institute of Seattle (Abhyankar M et al. Vaccine 35 (2017) 916).
C. DIFFICILE: The innate immune response to Clostridium difficile colitis is a new area of investigation. Also supported by a separate R01 to Dr. Petri from the NIH, his lab has discovered that eosinophils protect from C. difficile in both mice (Buonomo EL et al., Cell Reports 2016, 16:1-12) and humans (Kulaylat AS et al., JAMA Surg. doi:10.1001/jamasurg.2018.3174.) Understanding how eosinophils protect and why inflammasome activation by toxin activation of TLR2 causes death (Cowardin CA et al. Nature Microbiology 2016, doi:10.1038/nmicrobiol.2016.108) are current areas of focus.
CRYPTOSPORIDIOSIS: The acquired immune response to Cryptosporidium hominis in children growing up in the urban slums of Bangladesh is the third area of investigation. Supported by another NIH R01 grant, the focus of this research is the role of mucosal immunity in defense, including the identification of parasite proteins recognized by IgA and by immune T cells (Steiner KL et al. Clin Infect Dis. 2018 Apr 20. doi: 10.1093/cid/ciy310).
Nineteen graduate students have received their Ph.D. under Dr. Petri’s mentorship, all continuing in science, and 25 postdoctoral fellows. Eleven lab graduates have received K career development awards from the NIH, and nine have received their independent R01. There are five graduate students, three postdoctoral fellows, and six faculty conducting research in the Petri group.
(From 2020 onward)
- Global Biothreats Training Program
- Infectious Diseases Training Program
- Biodefense & Infectious Diseases Short-Term Training to Increase Diversity in Biomedical Research
- University of Virginia – icddr,b Research Unit for Women’s and Children’s Health Research
- Subunit Vaccine for Cryptosporidiosis
- Field Studies of Cryptosporidiosis in Bangladesh
- Role of Type 2 Immunity in Innate Protection from C. difficile
- Role of CREM in Amebic Colitis and Inflammatory Bowel Disease
- Role of Th17 in Severe and Recurrent C. difficile Infection
- Infectious Diseases Training Program
- Global Biothreats Training Program
- University of Virginia – icddr,b Research Unit for Women’s and Children’s Health Research
- Subunit Vaccine for Cryptosporidiosis
- Field Studies of Cryptosporidiosis in Bangladesh
- Role of Th17 in Severe and Recurrent C. difficile Infection
- Role of CREM in Amebic Colitis and Inflammatory Bowel Disease
- Infectious Diseases Training Program
- Global Biothreats Training Program
- Biodefense & Infectious Diseases Short-Term Training to Increase Diversity in Biomedical Research
- University of Virginia – icddr,b Research Unit for Women’s and Children’s Health Research
- Field Studies of Cryptosporidiosis in Bangladesh
- Role of eosinophils in innate protection from C. difficile
- Role of CREM in Amebic Colitis and Inflammatory Bowel Disease
- Role of Th17 in Severe and Recurrent C. difficile Infection
Turesky T, Xie W, Kumar S, Sliva DD, Gagoski B, Vaughn J, Zöllei L, Haque R, Kakon SH, Islam N, Petri WA, Nelson CA, Gaab N, Relating anthropometric indicators to brain structure in 2-month-old Bangladeshi infants growing up in poverty: A pilot study., 2020; NeuroImage. 210() 116540. PMID: 31945509 | PMCID: PMC7068701
Porfirio S, Archer-Hartmann S, Moreau GB, Ramakrishnan G, Haque R, Kirkpatrick BD, Petri WA, Azadi P, New strategies for profiling and characterization of human milk oligosaccharides., 2020; Glycobiology. () . PMID: 32248230
Donlan AN, Petri WA, Mucosal immunity and the eradication of polio., 2020; Science (New York, N.Y.). 368(6489) 362-363. PMID: 32327582
Burgess SL, Leslie JL, Uddin MJ, Oakland DN, Gilchrist CA, Moreau GB, Watanabe K, Saleh MM, Simpson M, Thompson BA, Auble DT, Turner SD, Giallourou N, Swann J, Pu Z, Ma JZ, Haque R, Petri WA, Gut microbiome communication with bone marrow regulates susceptibility to amebiasis., 2020; The Journal of clinical investigation. () . PMID: 32369444
Frisbee AL, Petri WA, Considering the Immune System during Fecal Microbiota Transplantation for Clostridioides difficile Infection., 2020; Trends in molecular medicine. 26(5) 496-507. PMID: 32359480 | PMCID: PMC7198612
Abhyankar MM, Ma JZ, Scully KW, Nafziger AJ, Frisbee AL, Saleh MM, Madden GR, Hays AR, Poulter M, Petri WA, Immune Profiling To Predict Outcome of Clostridioides difficile Infection., 2020; mBio. 11(3) . PMID: 32457246 | PMCID: PMC7251209
Williams FB, Kader A, Colgate ER, Dickson DM, Carmolli M, Uddin MI, Sharmin S, Islam S, Bhuiyan TR, Alam M, Nayak U, Mychaleckyj JC, Petri WA, Haque R, Qadri F, Kirkpatrick BD, Lee B, Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh., 2020; The Journal of infectious diseases. () . PMID: 32157282
Donlan A, Petri WA, The Inflammasome and Type-2 Immunity in Clostridium difficile Infection., 2020; Clinics in colon and rectal surgery. 33(2) 67-72. PMID: 32104158 | PMCID: PMC7042014
Wojcik GL, Korpe P, Marie C, Mentzer AJ, Carstensen T, Mychaleckyj J, Kirkpatrick BD, Rich SS, Concannon P, Faruque ASG, Haque R, Petri WA, Duggal P, Genome-Wide Association Study of Cryptosporidiosis in Infants Implicates PRKCA., 2020; mBio. 11(1). PMID: 32019797 | PMCID: PMC7002356
Gilmartin AA, Ralston KS, Petri WA, Inhibition of Amebic Cysteine Proteases Blocks Amebic Trogocytosis but Not Phagocytosis., 2020; The Journal of infectious diseases. 221(10) 1734-1739. PMID: 31999350 | PMCID: PMC7184912
Jensen SKG, Kumar S, Xie W, Tofail F, Haque R, Petri WA, Nelson CA, Neural correlates of early adversity among Bangladeshi infants., 2019; Scientific reports. 9(1) 3507. PMID: 30837491 | PMCID: PMC6401115
Steiner KL, Kabir M, Priest JW, Hossain B, Gilchrist CA, Cook H, Ma JZ, Korpe PS, Ahmed T, Faruque ASG, Haque R, Petri WA, Fecal IgA against a sporozoite antigen at 12 months is associated with delayed time to subsequent cryptosporidiosis in urban Bangladesh: a prospective cohort study., 2019; Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. () . PMID: 31131855
Moreau GB, Ramakrishnan G, Cook HL, Fox TE, Nayak U, Ma JZ, Colgate ER, Kirkpatrick BD, Haque R, Petri WA, Childhood growth and neurocognition are associated with distinct sets of metabolites., 2019; EBioMedicine. () . PMID: 31133540
Richard SA, McCormick BJJ, Murray-Kolb LE, Lee GO, Seidman JC, Mahfuz M, Ahmed T, Guerrant RL, Petri WA, Rogawski ET, Houpt E, Kang G, Mduma E, Kosek MN, Lima AAM, Shrestha SK, Chandyo RK, Bhutta Z, Bessong P, Caulfield LE, Enteric dysfunction and other factors associated with attained size at five years: MAL-ED birth cohort study findings., 2019; The American journal of clinical nutrition. () . PMID: 31127812
Berens AE, Kumar S, Tofail F, Jensen SEK, Alam M, Haque R, Kakon SH, Petri WA, Nelson CA, Cumulative psychosocial risk and early child development: validation and use of the Childhood Psychosocial Adversity Scale in global health research., 2019; Pediatric research. () . PMID: 31103019
Jensen SKG, Tofail F, Haque R, Petri WA, Nelson CA, Child development in the context of biological and psychosocial hazards among poor families in Bangladesh., 2019; PloS one. 14(5) e0215304. PMID: 31059509
Perdue KL, Jensen SKG, Kumar S, Richards JE, Kakon SH, Haque R, Petri WA, Lloyd-Fox S, Elwell C, Nelson CA, Using functional near-infrared spectroscopy to assess social information processing in poor urban Bangladeshi infants and toddlers., 2019; Developmental science. () e12839. PMID: 31017372
Turesky TK, Jensen SKG, Yu X, Kumar S, Wang Y, Sliva DD, Gagoski B, Sanfilippo J, Zöllei L, Boyd E, Haque R, Hafiz Kakon S, Islam N, Petri WA, Nelson CA, Gaab N, The relationship between biological and psychosocial risk factors and resting-state functional connectivity in 2-month-old Bangladeshi infants: a feasibility and pilot study., 2019; Developmental science. () e12841. PMID: 31016808
Saleh MM, Frisbee AL, Leslie JL, Buonomo EL, Cowardin CA, Ma JZ, Simpson ME, Scully KW, Abhyankar MM, Petri WA, Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection., 2019; Cell host & microbe. 25(5) 756-765.e5. PMID: 31003940 | PMCID: PMC6509008
Ramakrishnan G, Ma JZ, Haque R, Petri WA, Rotavirus vaccine protection in low-income and middle-income countries., 2019; The Lancet. Infectious diseases. 19(7) 673-674. PMID: 31178290 | PMCID: PMC6871505
Xie W, Jensen SKG, Wade M, Kumar S, Westerlund A, Kakon SH, Haque R, Petri WA, Nelson CA, Growth faltering is associated with altered brain functional connectivity and cognitive outcomes in urban Bangladeshi children exposed to early adversity., 2019; BMC medicine. 17(1) 199. PMID: 31760950 | PMCID: PMC6876085
Saleh MM, Petri WA, Type 3 Immunity during Clostridioides difficile Infection: Too Much of a Good Thing?, 2019; Infection and immunity. 88(1) . PMID: 31570564 | PMCID: PMC6921663
Tofail F, Islam MM, Mahfuz M, Ashraful Alam M, Aktar S, Haque R, Hossain MI, Mondal D, Petri WA, Ahmed T, Association of vitamin D nutrition with neurodevelopmental outcome of infants of slums in Bangladesh., 2019; PloS one. 14(9) e0221805. PMID: 31557172 | PMCID: PMC6762070
Mychaleckyj JC, Zhang D, Nayak U, Ross Colgate E, Carmolli M, Dickson D, Ahmed T, Alam M, Kirkpatrick BD, Haque R, Petri WA, Association of breast milk gamma-linolenic acid with infant anthropometric outcomes in urban, low-income Bangladeshi families: a prospective, birth cohort study., 2019; European journal of clinical nutrition. 74(5) 698-707. PMID: 31501475 | PMCID: PMC7214250
Xie W, Kumar S, Kakon SH, Haque R, Petri WA, Nelson CA, Chronic inflammation is associated with neural responses to faces in Bangladeshi children., 2019; NeuroImage. 202() 116110. PMID: 31449973 | PMCID: PMC6853162
Raman AS, Gehrig JL, Venkatesh S, Chang HW, Hibberd MC, Subramanian S, Kang G, Bessong PO, Lima AAM, Kosek MN, Petri WA, Rodionov DA, Arzamasov AA, Leyn SA, Osterman AL, Huq S, Mostafa I, Islam M, Mahfuz M, Haque R, Ahmed T, Barratt MJ, Gordon JI, A sparse covarying unit that describes healthy and impaired human gut microbiota development., 2019; Science (New York, N.Y.). 365(6449). PMID: 31296739 | PMCID: PMC6683326
Donowitz JR, Parikh HI, Taniuchi M, Gilchrist CA, Haque R, Kirkpatrick BD, Alam M, Kakon SH, Islam BZ, Afreen S, Kabir M, Nayak U, Colgate ER, Carmolli MP, Petri WA, Increased Fecal Lactobacillus Is Associated With a Positive Glucose Hydrogen Breath Test in Bangladeshi Children., 2019; Open forum infectious diseases. 6(7) ofz266. PMID: 31281862 | PMCID: PMC6602902
Frisbee AL, Saleh MM, Young MK, Leslie JL, Simpson ME, Abhyankar MM, Cowardin CA, Ma JZ, Pramoonjago P, Turner SD, Liou AP, Buonomo EL, Petri WA, IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection., 2019; Nature communications. 10(1) 2712. PMID: 31221971 | PMCID: PMC6586630
Wagar LE, Bolen CR, Sigal N, Lopez Angel CJ, Guan L, Kirkpatrick BD, Haque R, Tibshirani RJ, Parsonnet J, Petri WA, Davis MM, Increased T Cell Differentiation and Cytolytic Function in Bangladeshi Compared to American Children., 2019; Frontiers in immunology. 10() 2239. PMID: 31620139 | PMCID: PMC6763580
Kabir M, Ahmed E, Hossain B, Alam M, Ahmed S, Taniuchi M, Gilchrist CA, Houpt ER, Faruque ASG, Petri WA, Haque R, Giardia/Cryptosporidium QUIK CHEK® Assay is more Specific than qPCR for Rapid Point-of-care Diagnosis of Cryptosporidiosis in Infants in Bangladesh., 2018; Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. () . PMID: 29718129
Richard SA, McCormick BJJ, Seidman JC, Rasmussen Z, Kosek MN, Rogawski ET, Petri W, Bose A, Mduma E, Maciel BLL, Chandyo RK, Bhutta Z, Turab A, Bessong P, Mahfuz M, Caulfield LE, Relationships among Common Illness Symptoms and the Protective Effect of Breastfeeding in Early Childhood in MAL-ED: An Eight-Country Cohort Study., 2018; The American journal of tropical medicine and hygiene. 98(3) 904-912. PMID: 29380724 | PMCID: PMC5930868
Troeger C, Colombara DV, Rao PC, Khalil IA, Brown A, Brewer TG, Guerrant RL, Houpt ER, Kotloff KL, Misra K, Petri WA, Platts-Mills J, Riddle MS, Swartz SJ, Forouzanfar MH, Reiner RC, Hay SI, Mokdad AH, Global disability-adjusted life-year estimates of long-term health burden and undernutrition attributable to diarrhoeal diseases in children younger than 5 years., 2018; The Lancet. Global health. 6(3) e255-e269. PMID: 29433665 | PMCID: PMC5861379
Rogawski ET, Platts-Mills JA, Colgate ER, Haque R, Zaman K, Petri WA, Kirkpatrick BD, Quantifying the Impact of Natural Immunity on Rotavirus Vaccine Efficacy Estimates: A Clinical Trial in Dhaka, Bangladesh (PROVIDE) and a Simulation Study., 2018; The Journal of infectious diseases. 217(6) 861-868. PMID: 29514306 | PMCID: PMC5853827
Jiang NM, Cowan M, Moonah SN, Petri WA, The Impact of Systemic Inflammation on Neurodevelopment., 2018; Trends in molecular medicine. 24(9) 794-804. PMID: 30006148 | PMCID: PMC6110951
Schnee AE, Haque R, Taniuchi M, Uddin J, Alam M, Liu J, Rogawski ET, Kirkpatrick B, Houpt ER, Petri WA, Platts-Mills JA, Identification of etiology-specific diarrhea associated with linear growth faltering in Bangladeshi infants., 2018; American journal of epidemiology. () . PMID: 29767678
Duggal P, Petri WA, Does Malnutrition Have a Genetic Component?, 2018; Annual review of genomics and human genetics. 19() 247-262. PMID: 29874104
Marie C, Ali A, Chandwe K, Petri WA, Kelly P, Pathophysiology of environmental enteric dysfunction and its impact on oral vaccine efficacy., 2018; Mucosal immunology. () . PMID: 29988114
Schnee AE, Haque R, Taniuchi M, Uddin MJ, Petri WA, Evaluation of Two New Membrane-Based and Microtiter Plate Enzyme-Linked Immunosorbent Assays for Detection of Campylobacter jejuni in Stools of Bangladeshi Children., 2018; Journal of clinical microbiology. 56(9) . PMID: 29925645 | PMCID: PMC6113481
Uchiyama R, Kupkova K, Shetty SJ, Linford AS, Pray-Grant MG, Wagar LE, Davis MM, Haque R, Gaultier A, Mayo MW, Grant PA, Petri WA, Bekiranov S, Auble DT, Histone H3 lysine four methylation signature associated with human undernutrition., 2018; Proceedings of the National Academy of Sciences of the United States of America. 115(48) E11264-E11273. PMID: 30420518 | PMCID: PMC6275549
Kumar M, Ji B, Babaei P, Das P, Lappa D, Ramakrishnan G, Fox TE, Haque R, Petri WA, Bäckhed F, Nielsen J, Gut microbiota dysbiosis is associated with malnutrition and reduced plasma amino acid levels: Lessons from genome-scale metabolic modeling., 2018; Metabolic engineering. 49() 128-142. PMID: 30075203
Cowan M, Petri WA, Microglia: Immune Regulators of Neurodevelopment., 2018; Frontiers in immunology. 9() 2576. PMID: 30464763 | PMCID: PMC6234957
Abhyankar MM, Orr MT, Lin S, Suraju MO, Simpson A, Blust M, Pham T, Guderian JA, Tomai MA, Elvecrog J, Pedersen K, Petri WA, Fox CB, Adjuvant composition and delivery route shape immune response quality and protective efficacy of a recombinant vaccine for Entamoeba histolytica., 2018; NPJ vaccines. 3() 22. PMID: 29900011 | PMCID: PMC5988657
Wojcik GL, Marie C, Abhyankar MM, Yoshida N, Watanabe K, Mentzer AJ, Carstensen T, Mychaleckyj J, Kirkpatrick BD, Rich SS, Concannon P, Haque R, Tsokos GC, Petri WA, Duggal P, Genome-Wide Association Study Reveals Genetic Link between Diarrhea-Associated Entamoeba histolytica Infection and Inflammatory Bowel Disease., 2018; mBio. 9(5). PMID: 30228239 | PMCID: PMC6143743
Korpe PS, Gilchrist C, Burkey C, Taniuchi M, Ahmed E, Madan V, Castillo R, Ahmed S, Arju T, Alam M, Kabir M, Ahmed T, Petri WA, Haque R, Faruque ASG, Duggal P, Case-Control Study of Cryptosporidium Transmission in Bangladeshi Households., 2018; Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. () . PMID: 30192924 | PMCID: PMC6424084
Troeger C, Khalil IA, Rao PC, Cao S, Blacker BF, Ahmed T, Armah G, Bines JE, Brewer TG, Colombara DV, Kang G, Kirkpatrick BD, Kirkwood CD, Mwenda JM, Parashar UD, Petri WA, Riddle MS, Steele AD, Thompson RL, Walson JL, Sanders JW, Mokdad AH, Murray CJL, Hay SI, Reiner RC, Rotavirus Vaccination and the Global Burden of Rotavirus Diarrhea Among Children Younger Than 5 Years., 2018; JAMA pediatrics. 172(10) 958-965. PMID: 30105384 | PMCID: PMC6233802
Khalil IA, Troeger C, Rao PC, Blacker BF, Brown A, Brewer TG, Colombara DV, De Hostos EL, Engmann C, Guerrant RL, Haque R, Houpt ER, Kang G, Korpe PS, Kotloff KL, Lima AAM, Petri WA, Platts-Mills JA, Shoultz DA, Forouzanfar MH, Hay SI, Reiner RC, Mokdad AH, Morbidity, mortality, and long-term consequences associated with diarrhoea from Cryptosporidium infection in children younger than five years: a meta-analyses study., 2018; The Lancet. Global health. 6(7) e758-e768. PMID: 29903377 | PMCID: PMC6005120
Steiner KL, Ahmed S, Gilchrist CA, Burkey C, Cook H, Ma JZ, Korpe PS, Ahmed E, Alam M, Kabir M, Tofail F, Ahmed T, Haque R, Petri WA, Faruque ASG, Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study., 2018; Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 67(9) 1347-1355. PMID: 29897482 | PMCID: PMC6186860
Donowitz JR, Cook H, Alam M, Tofail F, Kabir M, Colgate ER, Carmolli MP, Kirkpatrick BD, Nelson CA, Ma JZ, Haque R, Petri WA, Role of maternal health and infant inflammation in nutritional and neurodevelopmental outcomes of two-year-old Bangladeshi children., 2018; PLoS neglected tropical diseases. 12(5) e0006363. PMID: 29813057 | PMCID: PMC5993301
Korpe PS, Valencia C, Haque R, Mahfuz M, McGrath M, Houpt E, Kosek M, McCormick BJJ, Penataro Yori P, Babji S, Kang G, Lang D, Gottlieb M, Samie A, Bessong P, Faruque ASG, Mduma E, Nshama R, Havt A, Lima IFN, Lima AAM, Bodhidatta L, Shreshtha A, Petri WA, Ahmed T, Duggal P, Epidemiology and Risk Factors for Cryptosporidiosis in Children From 8 Low-income Sites: Results From the MAL-ED Study., 2018; Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 67(11) 1660-1669. PMID: 29701852 | PMCID: PMC6233690
Sinha A, Kanungo S, Kim DR, Manna B, Song M, Park JY, Haldar B, Sharma P, Mallick AH, Kim SA, Babji S, Sur D, Kang G, Ali M, Petri WA, Wierzba TF, Czerkinsky C, Nandy RK, Dey A, Antibody secreting B cells and plasma antibody response to rotavirus vaccination in infants from Kolkata India., 2018; Heliyon. 4(1) e00519. PMID: 29560435 | PMCID: PMC5857522
Mychaleckyj JC, Nayak U, Colgate ER, Zhang D, Carstensen T, Ahmed S, Ahmed T, Mentzer AJ, Alam M, Kirkpatrick BD, Haque R, Faruque ASG, Petri WA, Multiplex genomewide association analysis of breast milk fatty acid composition extends the phenotypic association and potential selection of FADS1 variants to arachidonic acid, a critical infant micronutrient., 2018; Journal of medical genetics. 55(7) 459-468. PMID: 29514873 | PMCID: PMC6047159
Gilchrist CA, Cotton JA, Burkey C, Arju T, Gilmartin A, Lin Y, Ahmed E, Steiner K, Alam M, Ahmed S, Robinson G, Zaman SU, Kabir M, Sanders M, Chalmers RM, Ahmed T, Ma JZ, Haque R, Faruque ASG, Berriman M, Petri WA, Genetic diversity of Cryptosporidium hominis in a Bangladeshi community as revealed by whole-genome sequencing., 2018; The Journal of infectious diseases. () . PMID: 29514308 | PMCID: PMC6009673
Lee B, Carmolli M, Dickson DM, Colgate ER, Diehl SA, Uddin MI, Islam S, Hossain M, Rafique TA, Bhuiyan TR, Alam M, Nayak U, Mychaleckyj JC, McNeal MM, Petri WA, Qadri F, Haque R, Kirkpatrick BD, Rotavirus-Specific Immunoglobulin A Responses Are Impaired and Serve as a Suboptimal Correlate of Protection Among Infants in Bangladesh., 2018; Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 67(2) 186-192. PMID: 29394355 | PMCID: PMC6030840
Lee B, Dickson DM, deCamp AC, Ross Colgate E, Diehl SA, Uddin MI, Sharmin S, Islam S, Bhuiyan TR, Alam M, Nayak U, Mychaleckyj JC, Taniuchi M, Petri WA, Haque R, Qadri F, Kirkpatrick BD, Histo-Blood Group Antigen Phenotype Determines Susceptibility to Genotype-Specific Rotavirus Infections and Impacts Measures of Rotavirus Vaccine Efficacy., 2018; The Journal of infectious diseases. 217(9) 1399-1407. PMID: 29390150 | PMCID: PMC5894073
Kulaylat AS, Buonomo EL, Scully KW, Hollenbeak CS, Cook H, Petri WA, Stewart DB, Development and Validation of a Prediction Model for Mortality and Adverse Outcomes Among Patients With Peripheral Eosinopenia on Admission for Clostridium difficile Infection., 2018; JAMA surgery. () . PMID: 30208386
Mahfuz M, Alam MA, Fahim SM, Gazi MA, Raihan MJ, Hossain M, Egner PA, Bessong PO, Petri WA, Groopman JD, Ahmed T, Aflatoxin exposure in children living in Mirpur, Dhaka: data from MAL-ED companion study., 2018; Journal of exposure science & environmental epidemiology. () . PMID: 30185944
Kulaylat AS, Buonomo EL, Scully KW, Hollenbeak CS, Cook H, Petri WA, Stewart DB, Development and Validation of a Prediction Model for Mortality and Adverse Outcomes Among Patients With Peripheral Eosinopenia on Admission for Clostridium difficile Infection., 2018; JAMA surgery. () . PMID: 30208386
Gilmartin AA, Petri WA, Exploring the mechanism of amebic trogocytosis: the role of amebic lysosomes., 2018; Microbial cell (Graz, Austria). 5(1) 1-3. PMID: 29354646 | PMCID: PMC5772035
Watanabe K, Petri WA, Learning from the research on amebiasis and gut microbiome: Is stimulation by gut flora essential for effective neutrophil-mediated protection from external pathogens?, 2018; Gut microbes. () 1-5. PMID: 30252579
Ramakrishnan G, Petri WA, Secondary Carnitine Deficiency in Environmental Enteric Dysfunction., 2017; EBioMedicine. 17() 9-10. PMID: 28254256 | PMCID: PMC5360577
Upfill-Brown A, Taniuchi M, Platts-Mills JA, Kirkpatrick B, Burgess SL, Oberste MS, Weldon W, Houpt E, Haque R, Zaman K, Petri WA, Non-Specific Effects of Oral Polio Vaccine on Diarrheal Burden and Etiology among Bangladeshi Infants., 2017; Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. () . PMID: 28444240 | PMCID: PMC5848225
Ngobeni R, Samie A, Moonah S, Watanabe K, Petri WA, Gilchrist C, Entamoeba Species in South Africa: Correlations With the Host Microbiome, Parasite Burdens, and First Description of Entamoeba Bangladeshi Outside of Asia., 2017; The Journal of infectious diseases. () . PMID: 29236996 | PMCID: PMC5853652
Gilmartin AA, Ralston KS, Petri WA, Inhibition of Amebic Lysosomal Acidification Blocks Amebic Trogocytosis and Cell Killing., 2017; mBio. 8(4) . PMID: 28851845 | PMCID: PMC5574710
Jiang NM, Tofail F, Ma JZ, Haque R, Kirkpatrick B, Nelson CA, Petri WA, Early Life Inflammation and Neurodevelopmental Outcome in Bangladeshi Infants Growing Up in Adversity., 2017; The American journal of tropical medicine and hygiene. 97(3) 974-979. PMID: 28722635 | PMCID: PMC5590603
Burgess SL, Gilchrist CA, Lynn TC, Petri WA, Parasitic Protozoa and Interactions with the Host Intestinal Microbiota., 2017; Infection and immunity. 85(8) . PMID: 28584161 | PMCID: PMC5520446
Ali A, Zaman U, Mahmud S, Zahid GE, Kazi M, Petri WA, Bhutta Z, Zaidi A, Hughes MA, Impact of maternal respiratory infections on low birth weight – a community based longitudinal study in an urban setting in Pakistan., 2017; BMC pregnancy and childbirth. 17(1) 111. PMID: 28399895 | PMCID: PMC5387226
Platts-Mills JA, Taniuchi M, Uddin MJ, Sobuz SU, Mahfuz M, Gaffar SA, Mondal D, Hossain MI, Islam MM, Ahmed AS, Petri WA, Haque R, Houpt ER, Ahmed T, Association between enteropathogens and malnutrition in children aged 6-23 mo in Bangladesh: a case-control study., 2017; The American journal of clinical nutrition. 105(5) 1132-1138. PMID: 28381477 | PMCID: PMC5402031
Zhang Y, Zhou J, Niu F, Donowitz JR, Haque R, Petri WA, Ma JZ, Characterizing early child growth patterns of height-for-age in an urban slum cohort of Bangladesh with functional principal component analysis., 2017; BMC pediatrics. 17(1) 84. PMID: 28327104 | PMCID: PMC5359797
Lu M, Zhou J, Naylor C, Kirkpatrick BD, Haque R, Petri WA, Ma JZ, Application of penalized linear regression methods to the selection of environmental enteropathy biomarkers., 2017; Biomarker research. 5() 9. PMID: 28293424 | PMCID: PMC5345248
Noor Z, Watanabe K, Abhyankar MM, Burgess SL, Buonomo EL, Cowardin CA, Petri WA, Role of Eosinophils and Tumor Necrosis Factor Alpha in Interleukin-25-Mediated Protection from Amebic Colitis., 2017; mBio. 8(1). PMID: 28246365 | PMCID: PMC5347349
William Petri, MD PhD
E. histolytica infection in red blood cells.
E. histolytica infection in polymorphonuclear leukocytes.