Pathogenesis and Host Responses to Infectious Agents
Microbial pathogens, host responses to infection, and pathogen manipulation of host cell biology are the focus of investigation for UVA faculty from a range of disciplines. Many are members of the Carter Immunology Center and the Myles H. Thaler Center for AIDS and Human Retrovirus Research.
The following interdisciplinary faculty conduct research and instruct fellows in this area:
Genetic approaches, cellular and molecular biology of intracellular pathogen infection
Regulation of gene expression during lymphocyte development
T Lymphocyte Responses To Virus Infection
Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
Cell Biology of bacterial pathogenesis.
The innate immune response to bacterial infection.
Cellular and molecular mechanisms of Neisserial pathogenesis
Host/pathogen Interaction - Chlamydia Infection
Immune regulation for HCV infection and chronic liver inflammation
Structure and Function of Bacterial Toxins: Roles in Microbial Pathogenesis and Uses in Biomedical Research
Molecular mechanisms of microbial pathogenesis and antibiotic development
Biodefense and emerging pathogens
Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
Pathogenicity of Francisella tularensis and vaccines
Regulation of lung inflammation and antimicrobial immunity
Pathogenesis of diarrheagenic Escherichia coli and Shigella.
Immune mechanisms of defense against COVID-19 and enteric (diarrheal) infections
Iron-uptake mechanisms and Virulence Factors of Francisella tularensis; Microbial Pathogenesis
Apoptotic cell clearance mechanisms in health and disease
Molecular mechanisms of bacterial pathogenesis, sepsis/septic shock, adenosine receptors, inflammation, innate immunity, anthrax, vaccines
Hospital epidemiology, immunocompromised infectious diseases, molecular pathogenesis and epidemiology, innate immunity
Prevention and treatment of C. difficile infection. Role of microbiota in health and disease. Infections in special populations- elderly, pregnant women and racial/ethnic minority groups.