Pathogenesis and Host Responses to Infectious Agents
Microbial pathogens, host responses to infection, and pathogen manipulation of host cell biology are the focus of investigation for UVA faculty from a range of disciplines. Many are members of the Carter Immunology Center and the Myles H. Thaler Center for AIDS and Human Retrovirus Research.
The following interdisciplinary faculty conduct research and instruct fellows in this area:
Genetic approaches, cellular and molecular biology of intracellular pathogen infection
T Lymphocyte Responses To Virus Infection
Understanding how exposures in the intestine can influence the broader immune system.
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
Cell Biology of bacterial pathogenesis.
The innate immune response to bacterial infection.
Cellular and molecular mechanisms of Neisserial pathogenesis
Host/pathogen Interaction - Chlamydia Infection
Immune regulation for HCV infection and chronic liver inflammation
Biodefense and emerging pathogens
Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
Pathogenicity of Francisella tularensis and vaccines
Human intestinal parasitology
Host-pathogen interactions; molecular parasitology; mucosal inflammation; immunopathology and repair. Our research interests evolved from studying a parasite that causes inflammation of the gut, similar to IBD.
Immune mechanisms of defense against COVID-19 and enteric (diarrheal) infections
Iron-uptake mechanisms and Virulence Factors of Francisella tularensis; Microbial Pathogenesis
Clostridium difficile infection, infection in aged host, microbiome-immune response interactions, innate immune response
Hospital epidemiology, immunocompromised infectious diseases, molecular pathogenesis and epidemiology, innate immunity
Prevention and treatment of C. difficile infection. Role of microbiota in health and disease. Infections in special populations- elderly, pregnant women and racial/ethnic minority groups.