Pathogenesis and Host Responses to Infectious Agents

Microbial pathogens, host responses to infection, and pathogen manipulation of host cell biology are the focus of investigation for UVA faculty from a range of disciplines. Many are members of the Carter Immunology Center  and the Myles H. Thaler Center for AIDS and Human Retrovirus Research.

The following interdisciplinary faculty conduct research and instruct fellows in this area:

Herve Agaisse

Agaisse, Hervé

Genetic approaches, cellular and molecular biology of intracellular pathogen infection

Timothy Bender

Bender, Timothy P.

Regulation of gene expression during lymphocyte development

Thomas Braciale

Braciale, Thomas J.

T Lymphocyte Responses To Virus Infection

Michael Brown

Brown, Michael G.

Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation

James Casanova

Casanova, James E.

Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.<br> Cell Biology of bacterial pathogenesis. <br>The innate immune response to bacterial infection.

Alison Criss

Criss, Alison K.

Cellular and molecular mechanisms of Neisserial pathogenesis

Isabelle Derre

Derré, Isabelle

Host/pathogen Interaction - Chlamydia Infection

Young Hahn

Hahn, Young S.

Immune regulation for HCV infection and chronic liver inflammation

Erik Hewlett

Hewlett, Erik L.

Structure and Function of Bacterial Toxins: Roles in Microbial Pathogenesis and Uses in Biomedical Research

Paul Hoffman

Hoffman, Paul S.

Molecular mechanisms of microbial pathogenesis and antibiotic development

Molly Hughes

Hughes, Molly A.

Biodefense and emerging pathogens

Melissa Kendall

Kendall, Melissa M.

Bacterial cell signaling, host-pathogen interactions, intestinal pathogens

Thomas Loughran, Jr.

Loughran, Jr., Thomas P

Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)

Barbara Mann

Mann, Barbara J.

Pathogenicity of Francisella tularensis and vaccines

Borna Mehrad

Mehrad, Borna

Regulation of lung inflammation and antimicrobial immunity

James Nataro

Nataro, James P.

Pathogenesis of diarrheagenic Escherichia coli and Shigella.

William Petri

Petri, William A.

Immune mechanisms of defense against enteric (diarrheal) infections

Girija Ramakrishnan

Ramakrishnan, Girija

Iron-uptake mechanisms and Virulence Factors of Francisella tularensis; Microbial Pathogenesis

Kodi Ravichandran

Ravichandran, Kodi S.

Apoptotic cell clearance mechanisms in health and disease

W. Scheld

Scheld, W. Michael

Molecular mechanisms of bacterial pathogenesis, sepsis/septic shock, adenosine receptors, inflammation, innate immunity, anthrax, vaccines

Costi Sifri

Sifri, Costi D.

Hospital epidemiology, immunocompromised infectious diseases, molecular pathogenesis and epidemiology, innate immunity

Cirle Warren

Warren, Cirle A.

Recognition, pathogenesis, impact, and control of enteric infections.