Global Biothreats and Emerging Infectious Diseases

Emerging infectious diseases can be defined as infectious diseases that have newly appeared in a population or have previously existed but are rapidly increasing in incidence or geographic range. Biodefense pathogens are those that pose a risk to national security and/or public health, as defined by the National Institute of Allergy and Infectious Diseases’ (NIAID’s) list of category A, B, or C priority pathogens.

Research related to these urgent health threats encompasses a broad spectrum of themes, including investigations of pathogenicity and host responses, vaccines, therapeutics and diagnostic technologies.

The following interdisciplinary faculty conduct research and instruct fellows in this area:

Herve Agaisse

Agaisse, Hervé

Genetic approaches, cellular and molecular biology of intracellular pathogen infection

Alison Criss

Criss, Alison K.

Cellular and molecular mechanisms of Neisserial pathogenesis

Rebecca Dillingham

Dillingham, Rebecca Anne

Mobile technologies to improve adherence to HIV medications in rural populations.

Daniel Engel

Engel, Daniel A.

Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Influenza, Dengue and Ebola.

Erik Hewlett

Hewlett, Erik L.

Structure and Function of Bacterial Toxins: Roles in Microbial Pathogenesis and Uses in Biomedical Research

Eric Houpt

Houpt, Eric Robert

Molecular diagnostics, Tuberculosis, Global Health

Molly Hughes

Hughes, Molly A.

Biodefense and emerging pathogens

Peter Kasson

Kasson, Peter M.

Mechanisms of cell entry by influenza; Viral glycan recognition; drug resistance; molecular dynamics simulation; distributed computing.

Melissa Kendall

Kendall, Melissa M.

Bacterial cell signaling, host-pathogen interactions, intestinal pathogens

Barbara Mann

Mann, Barbara J.

Pathogenicity of Francisella tularensis and vaccines

James Nataro

Nataro, James P.

Pathogenesis of diarrheagenic Escherichia coli and Shigella.

William Petri

Petri, William A.

Immune mechanisms of defense against enteric (diarrheal) infections

Girija Ramakrishnan

Ramakrishnan, Girija

Iron-uptake mechanisms and Virulence Factors of Francisella tularensis; Microbial Pathogenesis

Lukas Tamm

Tamm, Lukas K.

Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions

Judith White

White, Judith M.

Virus Entry into Cells: Mechanisms and Development of Anti-Viral Therapeutics