Li Lab Publications

  1. Liang H, Li X, Shimer AL, Balian G, Shen FH*. A novel strategy of spine defect repair with a degradable bioactive scaffold preloaded with adipose-derived stromal cells. Spine J. 2014; 14(3):445-54
  2. Werner BC, Li X, Shen FH*. Stem cells in preclinical spine studies. Spine J. 2014;14(3):542-51.
  3. Yang D, Wang D, Shimer A, Shen FH, Li X, Yang X*. Glutathione protects human nucleus pulposus cells from cell apoptosis and inhibition of matrix synthesis. Connect Tissue Res. 2014; 55(2):132-9
  4. Liu Q, Cui Q, Li X, Jin Li*. The Applications of Buckminsterfullerene C60 and Derivatives in Orthopaedic Research. Connective Tissue Research, 2014; 55(2):71-9
  5. Yang X, Jin L, Yao L, Shen FH, Shimer A, Li X*. Antioxidative Nano-fullerol Prevents Intervertebral Disc Degeneration. International Journal of Nanomedicine, 2014; 9: 1-12
  6. Li X*, Jin L, Shen FH: Tissue engineering of the intervertebral disk. Orthopaedic Knowledge Online Journal 2014;12(5)
  7. Jin L*, Liu Q, Scott P, Zhang D, Shen FH, Balian G, Li X. Annulus Fibrosus Cell Characteristics Are a Potential Source of Intervertebral Disc Pathogenesis. PLoS One. 2014;5;9(5):e96519.
  8. Zhu C, Ming Z, Liu K, Wan Y, Li X, Feng G*. Novel chitosan hydrogel formed by ethylene glycol chitosan, 1,6-diisocyanatohexan and polyethylene glycol-400 for tissue engineering scaffold: in vitro and in vivo evaluation. Journal of Materials Science: Materials in Medicine, 2014;25(8):1903-13
  9. Li X, Jin L, Hassanzadeh H*, Shen FH. State of the art and future of stem cells in spine. Seminars in Spine Surgery, 2015;27(2):93-102
  10. Liu Q, Jin L, Shen FH, Balian G, Li X*. Fullerol nanoparticles suppress inflammatory response and adipogenesis of vertebral bone marrow stromal cells-A novel treatment for intervertebral disc degeneration. Spine J. 2013;13(11):1571-80.
  11. Yang XL, Shang HL, Katz A, Li X*. GDF-5 mediated chondrogeneiss in microsphere culture. Biores Open Access. 2013;2(4):258-65
  12. Liu Q, Jin L, Mahon BH, Chordia MD, Shen FH, Li X*. A novel treatment of neuroinflammation against low back pain by soluble Fullerol nanoparticles. Spine. 2013;38(17):1443-51.
  13. Jin L, Shimer AL, Li X*. The Challenge and Advancement of Annulus Fibrosus Tissue Engineering. Eur Spine J. 2013;22(5):1090-100
  14. Jin L, Li X*. Growth and Differentiation Factor 5 in Bone Regeneration. Current Pharmacology Design. Curr Pharm Des. 2013;19(19):3364-73
  15. Shen FH*, Werner BC, Liang H, Shang H, Yang N, Li X, Shimer AL, Balian G, Katz AJ. Implications of adipose-derived stromal cells in a 3D culture system for osteogenic differentiation: an in vitro and in vivo investigation. Spine J. 2013;13(1)32-43 2013 Outstanding Paper Runner up
  16. Jin L, Feng G, Reames DL, Li X*. The effect of simulated microgravity on intervertebral disc degeneration. Spine J. 2013; 13(3):235-42.
  17. Zhang D, Jin L, Shen FH, Li X*. The effect of ApoE on intervertebral disc. Journal of Orthopaedic Research, J Orthop Res. 2013;31(2):210-7
  18. Jin L, Wan Y, Shen FH, Li X*. Intervertebral Disc-Like Biphasic Scaffold – DBM Cylinder and PPCLM – for Interbody Spine Fusion. Journal of Tissue Engineering. 2012;3(1):2041731412454420
  19. Kapur SK, Wang X, Shang H, Yun S, Li X, Feng G, Khurgel M, Katz AJ*. Human adipose stem cells maintain proliferative, synthetic and multipotential properties when suspension cultured as self-assembling spheroids. Biofabrication 2012;4(2):025004
  20. Liu HJ, Yang XL, Zhang Yi, Dighe A, Li X, Cui Q*. Fullerol antagonizes dexamethasone-induced oxidative stress and adipogenesis while enhancing osteogenesis in a cloned bone marrow mesenchymal stem cell. Journal of Orthopaedic Research 2012; 30(7):1051-7
  21. Yang XL, Wang DD, Hao JR, Gong MQ, Arlet V, Balian G, Shen FH, Li X*. Enhancement of matrix production and cell proliferation in human annulus cells under bioreactor culture. Tissue Engineering Part A, 2011; 17(11-12):1595-603
  22. Liang H, Wang K, Shimer AL, Li X, Balian G, Shen FH*. Use of a bioactive scaffold for the repair of bone defects in a novel reproducible vertebral body defect model. Bone. 2010; 47(2):197-204
  23. Yang X, Wan Y, Qiao X, Arlet V, Li X*. Transcriptional alteration of matrix-related gene expression in cultured human disc cells by nanoparticles of a bis-methanophosphonate fullerene. Cell Biol Int. 2010; 34(8):837-44.
  24. Deng M, Nair LS, Nukavarapu SP, Jiang T, Kanner WA, Li X, Kumbar SG, Weikel AL, Krogman NR, Allcock HR, Laurencin CT*. Dipeptide-based polyphosphazene and polyester blends for bone tissue engineering. Biomaterials. 2010; 31(18):4898-90
  25. Gong M, Zhang D, Wan Y, Edmondson B, Cui Q, Li X*. Engineered Synovial Joint Condyle using Demineralized Bone Matrix. Material Science and Engineering C. 2010; 30: 531-536
  26. Feng G, Yang X, Shang H, Ian Marks, Shen FH, Katz A, Arlet V, Laurencin CT, Li X*. Multipotential differentiation of human annulus fibrosus cells – an in vitro study. Journal of Bone and Joint Surgery. 2010; 92(3):675-85
  27. Liang H, Shen-Ying Ma, Feng G, Shen FH, Li X*. In vivo study of adenovirus-mediated gene transfer of Growth and Differentiation Factor-5 to treat disc degeneration induced by annulus needle-puncture. Spine Journal, 2010; 10(1):32-41. 2009 Outstanding Paper Runner up
  28. Yang X, Li X*. Nucleus pulposus tissue engineering: state of the art. European Spine Journal. 2009; 18(11):1564-72.
  29. Yang P, Wang C, Shi Z, Huang X, Dang X, Li X, Lin S-F, Wang K*. rhVEGF165 Delivered in a Porous β-Tricalcium Phosphate Scaffold Accelerate Bridging of Critical-Sized Defects in Rabbit Radii. Journal of Biomedical Materials Research: Part A, 2010; 92(2):626-40
  30. Feng G, Wan Y, Shen FH, Li X*. Nucleus Pulposus Explant Culture Model. Journal of Orthopaedic Research, 2009; 27(6):814-9.
  31. Feng G, Wan Y, Balian G, Laurencin CT, Li X*. Adenovirus-Mediated Expression of Growth and Differentiation Factor-5 Promotes Chondrogenesis of Adipose Stem Cells. Growth Factors. 2008; 26(3):132-42
  32. Wan Y, Feng G, Shen FH, Laurencin CT, Li X*. Biphasic Scaffold for Annulus Fibrosus Tissue Regeneration. Biomaterials. 2008; 29(6):643-52.
  33. Cui M, Wan Y, Anderson DG, Shen FH, Leo BM, Laurencin CT, Balian G, Li X*. GDF-5 Protein and DNA Therapy Potentiates Intervertebral Disc Cell Aggregation and Chondrogenic Gene Expression. Spine Journal, 2008; 8(2):287-95. (Outstanding Paper Award)
  34. Wan Y, Feng G, Shen FH, Balian G, Laurencin CT, Li X*. Novel Biodegradable Poly (1, 8-diol malate (POM) for Annulus Fibrosus Regeneration. Macromolecular Bioscience.2007; 7(11):1217-24.
  35. Zeng Q, Li X, Choi L, Beck G. Balian G, Shen FH*. Stimulation of osteogenic differentiation in fat-derived stromal cells in vitro using recombinant growth and differentiation factor-5 (GDF-5) and BMP-2 with different regulatory mechanisms. Bone. 2007; 40(2):374-381
  36. Zeng Q, Li X, Choi L, Beck G. Balian G, Shen FH*. Recombinant growth/differentiation factor-5 (GDF-5) stimulates osteogenic differentiation of fat-derived stromal cells in vitro. Connective Tissue Research, 2006; 47(5):264-70
  37. Shen FH, Zeng Q, Lv Q, Choi L, Balian G. Li X, Laurencin CT*. Osteogenic differentiation of adipose-derived stromal cells treated with GDF-5 cultured on a novel three-dimensional sintered microsphere matrix. Spine Journal, 2006; 6(6):615-23 (Outstanding Paper Award)
  38. Cui Q*, Xiao Z, Li X, Saleh K, Balian G. Use of genetically engineered bone-marrow stem cells to treat femoral defects: an experimental study. Journal of Bone and Joint Surgery, 2006; 88(Suppl 3):167-72
  39. Li X*, Jin L, Balian G, Laurencin CT, Anderson DG. Demineralized Bone Matrix Gelatin as Scaffold for Osteochondral Tissue Engineering. Biomaterials, 2006; 27(11):2426-33
  40. Li X*, Lee JP, Balian G, Anderson DG. Modulation of Chondrocytic Properties of Fat-derived Mesenchymal Cells in co-cultures with Nucleus Pulposus. Connective Tissue Research, 2005; 42 (2):1-6
  41. Anderson DG*, Li X, Balian G. A Fibronectin Fragment Alters the Metabolism by Intervertebral Disc Cells in vitro. Spine, 2005; 30(11):1242-1246
  42. Kofron MD, Li X, Laurencin CT*. Protein and gene-based tissue engineering in bone repair. Current Opinion in Biotechnology, 2004; 15(5):399-405
  43. Li X*, Jin L, Cui Q, Wang G-J, Balian G: Steroid effects on osteogenesis through mesenchymal cell gene expression. Osteoporosis International, 2004; 16: 101-108
  44. Li X*, Leo BM, Beck G, Balian G, Anderson DG. Collagen and proteoglycan abnormalities in GDF-5 deficient mice may be corrected by treating disc cells with recombinant growth factor. Spine, 2004; 29(20):2229-2234
  45. Leo BM, Li X, Balian G, Anderson DG*. In vivo bioluminescent imaging of virus mediated gene transfer and transduced cell transplantation in the intervertebral disc. Spine, 2004; 29(8): 838-844
  46. Li X*, Cui Q, Wang GJ, Balian G: Lovastatin Inhibits Adipogenic and Stimulates Osteogenic Differentiation by Suppressing PPARc2 and Increasing Cbfa1/Runx2 Expression in Bone Marrow Mesenchymal Cell Culture. Bone, 2003; 33(4): 652-659
  47. Anderson DG*, Li X, Tannoury T, Beck G, Balian G: A Fibronectin Fragment Stimulates Intervertebral Disc Degeneration in vivo. Spine, 2003; 28(20): 2338-2345
  48. Li X*, Wang K, Chen, J, et al: Significance of nitric oxide on the pathogenesis of steroid-induced femoral head necrosis. Chinese Journal of Traumatology, 2000; 3(1):62-63
  49. Li X*, Wang K, Yan H, Chen J: Abnormal expression of HLA-DR antibody in affected synovium from Perthes The Orthopedic Journal of China, 1999; 12(6):912-913
  50. Li X*, Wang K, Chen J: Biochemistry studies on proteoglycan content in affected cartilage and hyaluronic acid levels in serum and synovial fluid of Perthes Journal of Chinese Pediatric Surgery, 1999; 20(3):159-161
  51. Li X*, Wang K, Chen J: Increased level of nitric oxide in the serum of steroid-induced femoral head necrosis. Journal of Xi’an Med Univ (Eng), 1999;11(1):78-81
  52. Li X*, Wang K, Li Y: Abnormal expression of HLA-DR antibody in affected synovium from steroid-induced femoral head necrosis. Journal of Xi’an Med Univ, 1999; 20(1):68-70
  53. Li X*, Wang K, Chen J: Biochemistry studies on proteoglycan content in affected cartilage, hyaluronic acid levels in serum and synovial fluid of Perthes disease. Journal of Xi’an Med Univ (Eng.), 1998; 10(1):181-185
  54. Wang K*, Li X, Dang X: Reconstruction of Shank and Foot Soft Tissue Damage and Defects with Tibia Anterior Pedicled Flap. Journal of Xi’an Med Univ, 1996; 19(2): 125-126
  55. Wang K*, Wang C, Yang W, Li X, Yang X: Experimental study on free vascularized fibular grafting in revascularzing femoral head. Journal of Xi’an Med Univ (Eng.), 1996; 8(2):123-128
  56. Li X*, Yang Q. Pathogenesis and surgical treatment for syringomyelia. Journal of Shanxi Med, 1996; 25(3): 221-223
  57. Li X*, Yang Q. The mechanism of hypothermia celebraoprotective effect on brain ischemia. Journal of Shaanxi Med, 1996; 25(2):104-108