Translational Research & Applied Statistics
About
Led by Gina R. Petroni, Ph.D., The Division of Translational Research and Applied Statistics (TRAppS) provides an analytical infrastructure for basic, clinical, and translational research.
- Members use their expertise to help develop, foster and lead discovery and innovation for translational science across the University of Virginia.
- The Division has statistical expertise in pre-clinical studies and in all phases of clinical research with a particular emphasis on methodology related to early stage clinical trials.
Early phase study design
We design innovative clinical trials by developing and implementing novel statistical methodology that will answer research questions being posed in contemporary early development trials. We are part of a national research effort to change the way early phase trials are done through the Center for Early Phase Trials (CEPT).
- Experimental designs and analysis
- Analyses of tumor outgrowth studies
- Biomarker discovery
Propose and implement appropriate study designs to meet the study objectives, including sample size determination and statistical analysis plans
- Optimal single arm, fully or group sequential designs
- Designs for bivariate outcomes
- Randomized phase II
- Randomized multi-arm comparative trials
- Group Sequential and Adaptive Designs
- Preference Option Randomized Designs
- Factorial Designs
- Randomization and adaptive assignment
- Interim analysis
- Continuous adverse event tracking
- Data and safety monitoring board reports
- Develop analysis plans and experimental designs to meet study objectives
- Write statistical considerations and design justifications for clinical and preclinical experiments
- Diagnostic & screening tests
- Instrument development
- Linear, nonlinear and multiple regression
- Logistic, polytomous, and Poisson regression
- Mixed models
- Nonparametric estimation
- Product-limit and competing risks estimation
- Prognostic markers
- Proportional hazards regression
- Quality of Life measurements
- Quantile regression
- Repeated measures analysis
- Resampling methods
- One to one mentoring in clinical and pre-clinical research
- Short courses and invited lectures in graduate courses
- Courses in the DPHS programs
- Workshops and presentations at national meetings
Recent Division Highlights
- Dr. Petroni was named a fellow of the American Society of Clinical Oncology. She is one of just a handful of statisticians to earn this honor.
- Dr. Conaway received the UVA School of Medicine inaugural 2024 Dean’s Award for Excellence in Faculty Mentorship.
- Dr. Horton is the the lead statistician for the Data Management and Reporting Core for the Cystic Fibrosis Learning Network which was recently transferred to UVA. The team also includes divisions members Shiyi Shen and David Brighton.
- Dr. Conaway is PI of an NIH/R03 award entitled “An evaluation of composite endpoints using data from the EXCITE trial”.
Translational Research & Applied Statistics Contact Information
Faculty and staff in the Division of Translational Research and Applied Statistics provide the analytical infrastructure for basic, clinical, and translational research at the University of Virginia.
| Name | Phone | E-mail Address |
|---|---|---|
| Petroni, Gina - Director | 434-924-8363 | gpetroni@virginia.edu |
| Conaway, Mark | 434-924-8510 | mconaway@virginia.edu |
| Horton, Beth | 434-243-7236 | bhorton@virginia.edu |
| Varhegyi, Nikole | 434-924-8759 | nev4g@virginia.edu |
| Shen, Shiyi | zjn4fm@virginia.edu | |
| Brighton, David | gca6xx@virginia.edu | |
| Miner, Cherie | edn8uw@virginia.edu |