Division of Translational Research & Applied Statistics
About
Cancer Center Consultation Request Form
Click HereLead by Gina R. Petroni, Ph.D., The Division of Translational Research and Applied Statistics (TRAppS) provides an analytical infrastructure for basic, clinical, and translational research, specifically in cancer. We are the academic home of the Biostatistics Shared Resource for the UVA Cancer Center.
- Members use their expertise to help develop, foster and lead discovery and innovation for translational science across the University of Virginia.
- The Division has statistical expertise in pre-clinical studies and in all phases of clinical research with a particular emphasis on methodology related to early stage clinical trials.
Cancer Center Consultation Request Form
Click HereEarly phase study design
We design innovative clinical trials by developing and implementing novel statistical methodology that will answer research questions being posed in contemporary early development trials. We are part of a national research effort to change the way early phase trials in oncology are done through the Center for Early Phase Trials (CEPT).
- Experimental designs and analysis
- Analyses of tumor outgrowth studies
- Biomarker discovery
Propose and implement appropriate study designs to meet the study objectives, including sample size determination and statistical analysis plans
- Optimal single arm, fully or group sequential designs
- Designs for bivariate outcomes
- Randomized phase II
- Randomized multi-arm comparative trials
- Group Sequential and Adaptive Designs
- Preference Option Randomized Designs
- Factorial Designs
- Randomization and adaptive assignment
- Interim analysis
- Continuous adverse event tracking
- Data and safety monitoring board reports
- Develop analysis plans and experimental designs to meet study objectives
- Write statistical considerations and design justifications for clinical and preclinical experiments
- Diagnostic & screening tests
- Instrument development
- Linear, nonlinear and multiple regression
- Logistic, polytomous, and Poisson regression
- Mixed models
- Nonparametric estimation
- Product-limit and competing risks estimation
- Prognostic markers
- Proportional hazards regression
- Quality of Life measurements
- Quantile regression
- Repeated measures analysis
- Resampling methods
- One to one mentoring in clinical and pre-clinical research
- Short courses and invited lectures in graduate courses
- Courses in the DPHS programs
- Workshops and presentations at national meetings
Recent Division Highlights
- Dr. Petroni has been elected by the NCI’s Investigational Drug Steering Committee (IDSC) as a new IDSC Biostatistician Subject Matter Expert. The IDSC was created at the recommendation of the National Cancer Institute’s Clinical Trials Working Group to assist with the design and prioritization of early phase drug development trials with agents for which the Cancer Therapy Evaluation Program (CTEP) holds an Investigational New Drug application (IND).
- Dr. Wages will serve as a member of the teaching faculty at the inaugural Society for Immunotherapy of Cancer Clinical Immuno-Oncology Network (SCION) Workshop, which is planned for January 23-28, 2022 in Austin, TX.
- Dr. Conaway and colleague’s paper “Minimizing Glucose Excursions (GEM) With Continuous Glucose Monitoring in Type 2 Diabetes: A Randomized Clinical Trial” has been selected as the Journal of the Endocrine Society Featured Article for the week of Oct 28.
- Congratulations to Drs. Conaway & Horton, who are part of the team who received the 2020 Dean’s Award for Excellence in Research: Team Science. The award was given to the team led by Drs. Tom Loughran & Mark Kester for their work on the recently funded P01 award from NIH “TARGETED SPHINGOLIPID METABOLISM FOR TREATMENT OF AML.”
- Dr. Wages is the PI of an NIH/NCI R01 award entitled “Dose-finding designs for late-onset toxicities.”
Translational Research & Applied Statistics Contact Information
Faculty and staff in the Division of Translational Research and Applied Statistics provide the analytical infrastructure for basic, clinical, and translational research at the University of Virginia, specifically in cancer, and in close collaboration with faculty and staff in the UVA NCI-Designated Comprehensive Cancer Center.
| Name | Phone | E-mail Address |
|---|---|---|
| Petroni, Gina - Director | 434-924-8363 | gpetroni@virginia.edu |
| Conaway, Mark | 434-924-8510 | mconaway@virginia.edu |
| Horton, Beth | 434-243-7236 | bhorton@virginia.edu |
| Varhegyi, Nikole | 434-924-8759 | nev4g@Virginia.EDU |