Complex diseases

The Sheynkman Lab has ongoing projects related to detecting protein drivers of disease with underpinnings of genetic variation and alternative splicing. Some specific areas of focus include chronic obstructive pulmonary disease, bone mineral density (ie, osteoporosis), coronary artery disease, asthma, and fibrotic lung diseases.

Some of our previous projects that have focused on complex diseases can be found here:

Abdullah Abood, Larry D. Mesner, Erin D. Jeffery , Mayank Murali , Micah Lehe , Jamie Saquing , Charles R. Farber, Gloria M. Sheynkman. 2024. Long-read proteogenomics to connect disease-associated sQTLs to the protein isoform effectos of disease

Madison M. Mehlferber, Ben T. Jordan, Erin D. Jeffery, Leon Sheynkman, Jamie Saquing, Bipul R. Acharya, Karen K. Hirschi, Gloria M. Sheynkman. 2022. Characterization of protein isoform diversity in human umbilical vein endothelial cells (HUVECs) via long-read proteogenomics

 

A review of experimental and computational approaches that characterize gene regulatory networks, splice regulatory networks, and the resulting transcriptome and proteome they mediate during differentiation (applicable for all complex diseases) can be found here:

Madison M. Mehlferber, Muge Kuyumcu‑Martinez, Clint L. Miller, Gloria M. Sheynkman. 2023. Transcription Factors and Splice Factors—Interconnected Regulators of Stem Cell Differentiation