6/17/2025
Research Description One of the major goals of my research program is to understand the role of membrane microdomains such as lipid rafts and caveolae in health and disease. We address…
6/17/2025
SERCA2a [the Ca-ATPase of sarcoplasmic reticulum (SR) of cardiac muscle] plays a central role in intracellular calcium dynamics and thus in the contractility of the heart. The SR regulates the…
6/17/2025
6/17/2025
Brain insulin resistance is a significant feature of dementia.Dementia is a group of neurological and vascular disorders that are characterized by cognitive impairment that is severe enough to interfere with…
9/10/2025
The structure and composition of the plasma membrane is a major determinant of its function, and while recent advances in super-resolution microscopy and isolated mammalian plasma membranes have provided key…
6/17/2025
Sequence variation in seven transmembrane spanning receptors, which couple to heterotrimeric G proteins, provides specificity for agonist recognition as well as activation of particular G proteins. A G protein is…
6/17/2025
Our laboratory studies macromolecular structures with an aim toward an in-depth understanding of structure-function relationships. X-ray diffraction analysis is our primary research tool, but we also employ other physical and…
6/17/2025
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or StrokeAtherothrombosis, resulting from rupture or…
