6/17/2025
Structural biology of membrane and soluble proteins using cryo-EM, X-ray crystallography, MicroED, molecular modeling, and molecular dynamics simulations.
6/17/2025
My laboratory aims to explore the physiological role of endoplasmic reticulum (ER) homeostasis (with a special focus on ER-associated degradation, ERAD) in the context of human diseases. We use genetic,…
6/17/2025
All eukaryotic cells divide by assembling a microtubule-based spindle machinery that equally segregates chromosomes between daughter cells. The faithful segregation of chromosomes during cell division is essential as errors in…
6/27/2025
Atherosclerosis is a chronic inflammatory disease whose late-stage clinical complications including myocardial infarction (heart attack) and stroke, are the leading causes of death worldwide. Clinical trials of anti-inflammatory therapies yield…
6/17/2025
Our research covers several related but different areas. One of the major areas of research is the development of state of art instrumentation for biological studies. These have included the…
6/17/2025
The post-genomic era is marked by the development of technologies which have revealed the astonishing molecular diversity of gene products. Multiple distinct protein forms, or “proteoforms”, can arise through several…
6/21/2025
Our research focuses on the molecular basis of smooth muscle contraction, the role of RhoA GTP exchange factors (GEFs) and GTP activating proteins (GAPs) in smooth muscle signaling, and identifying…
6/17/2025
The Sonkusare laboratory studies the role of ion channels and calcium signaling mechanisms in regulating vascular function and blood pressure. Constriction of small arteries is a crucial determinant of blood…
6/17/2025
Our lab studies the structure and function of several membrane proteins of clinical importance in their natural membrane environment. We are also interested in the roles that membrane lipids play…
6/17/2025
My research is aimed towards understanding the role of microtubules, motors and components of membrane domains in Clathrin Independent Endocytosis (CIE) of growth factor receptors and other cargoes including bacterial…
