Bielinsky-Hendrickson Lab

Our laboratory is interested in all aspects of DNA metabolism, including 1) DNA replication, 2) DNA repair, 3) DNA recombination, 4) gene editing, and 5) telomeres. DNA replication and repair networks work together to maintain genome stability. When these networks are compromised, cells experience aberrant DNA replication, increased mutation rate and chromosome breakage. The combination of these events results in a variety of genetic diseases that are commonly referred to as genome instability syndromes. They include bone marrow failure, cancer and immune deficiencies. We use CRISPR-mediated gene editing to model patient mutations that interfere with genome maintenance in human tissue culture cells and uncover the molecular mechanism(s) underlying these diseases. Our laboratory utilizes a combination of cellular, molecular and bioinformatics tools to investigate how eukaryotic DNA replication and repair are regulated during the cell cycle and describe the damaging consequences that arise when these processes do not proceed normally. Finally, we are optimizing gene editing approaches with a strong focus on devising novel strategies for gene therapy.

We believe that science is for everybody and we recognize that a diverse group strengthens our laboratory. We strive to create an inclusive environment for all laboratory members to succeed while being their full selves.

Green Labs
The Bielinsky-Hendrickson laboratory is working to actively promote green laboratory practices.