Stroupe, Christopher

Christopher  Stroupe

Christopher Stroupe

Primary Appointment

Assistant Professor, Molecular Physiology and Biological Physics

Education

  • SB, Biology, Massachusetts Institute of Technology
  • PhD, Molecular Biophysics and Biochemistry, Yale University

Contact Information


Telephone: 434-243-1413
Email: chris.stroupe@virginia.edu

Research Interests

Biochemical, biophysical, structural, and cell biological studies of intracellular membrane tethering and fusion

Research Description

Our lab uses biochemical, biophysical, structural, and cell biological techniques to study the molecular mechanisms underlying intracellular membrane tethering and fusion in eukaryotes. Research in the lab centers around a six-subunit complex called HOPS (homotypic vacuole fusion and protein sorting). HOPS is needed for fusion of yeast vacuoles (analogous to lysosomes in metazoan cells) and for traffic from the Golgi apparatus and endosomes to the vacuole. HOPS is an effector for the vacuolar Rab GTPase Ypt7p, that is, it is recruited to membranes by GTP-bound Ypt7p. It also interacts with vacuolar SNARE" proteins. (SNAREs are thought to directly catalyze membrane fusion through formation of membrane-bridging "trans-SNARE complexes".) Clearly

Selected Publications