Diane L. Rosin | University of Virginia School of Medicine

Bio & Overview

I am interested in understanding immune mechanisms involved in acute and chronic kidney injury and the mechanisms that may underlie the progression of acute to chronic kidney disease. The availability of a large array of transgenic mice contributes important tools for teasing out these mechanisms. We use a variety of in vivo and in vitro models along with molecular, cell biological and immunological methods to study kidney injury and to guide development of novel pharmacological and cell based therapy approaches for modulating pathways that contribute to kidney injury. Some of our current work focuses on using ligands of adenosine 2A receptors and sphingosine 1-phosphate receptors to protect kidneys from insults that produce acute and chronic kidney injury. In addition we are exploring nanoparticle-mediated targeted delivery of drugs to the kidney as a novel and possibly more selective treatment modality. Some of the models that we use include: 1) Kidney ischemia-reperfusion injury as a model of acute kidney injury 2) Folic acid or aristolochic acid-induced kidney fibrosis. Interstitial fibrosis is one of the hallmarks of chronic kidney disease 3) Ischemia-reperfusion injury-induced fibrosis in mice maintained for longer time periods as a model of progression from acute to chronic kidney injury. 4) Hypoxia- or LPS-induced injury in cultured renal tubular epithelial cells, glomerular endothelial cells, and primary cultures of kidney fibroblasts.

Academic Information

Department: Pharmacology

Academic Title: Postdoctoral Researcher

Primary Education

PhD, undefinedVirginia Commonwealth University, 1982

Other Affiliations

BIMS

Research Interests

Immunological mechanisms of acute kidney injury and progressive kidney disease

Selected Publications

2019

Inoue, T., Tanaka, S., Rosin, D. L., & Okusa, M. D. (2019). Bioelectronic Approaches to Control Neuroimmune Interactions in Acute Kidney Injury. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 9(6). doi:10.1101/cshperspect.a034231

Inoue, T., Abe, C., Kohro, T., Tanaka, S., Huang, L., Yao, J., . . . Okusa, M. D. (2019). Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/reperfusion injury in the kidney. KIDNEY INTERNATIONAL, 95(3), 563-576. doi:10.1016/j.kint.2018.09.020

2018

Jankowski, J., Perry, H. M., Medina, C. B., Huang, L., Yao, J., Bajwa, A., . . . Okusa, M. D. (2018). Epithelial and Endothelial Pannexin1 Channels Mediate AKI. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 29(7), 1887-1899. doi:10.1681/ASN.2017121306

2017

Perry, H. M., Huang, L., Wilson, R. J., Bajwa, A., Sesaki, H., Yan, Z., . . . Okusa, M. D. (2018). Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 29(1), 194-206. doi:10.1681/ASN.2017060659

Okusa, M. D., Rosin, D. L., & Tracey, K. J. (2017). Targeting neural reflex circuits in immunity to treat kidney disease. NATURE REVIEWS NEPHROLOGY, 13(11), 669-680. doi:10.1038/nrneph.2017.132

Stremska, M. E., Jose, S., Sabapathy, V., Huang, L., Bajwa, A., Kinsey, G. R., . . . Sharma, R. (2017). IL233, A Novel IL-2 and IL-33 Hybrid Cytokine, Ameliorates Renal Injury. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 28(9), 2682-2694. doi:10.1681/ASN.2016121272

Abe, C., Inoue, T., Inglis, M. A., Viar, K. E., Huang, L., Ye, H., . . . Guyenet, P. G. (2017). C1 neurons mediate a stress-induced anti-inflammatory reflex in mice. NATURE NEUROSCIENCE, 20(5), 700-+. doi:10.1038/nn.4526

2016

Bajwa, A., Huang, L., Kurmaeva, E., Ye, H., Dondeti, K. R., Chroscicki, P., . . . Okusa, M. D. (2017). Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-γ. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 28(4), 1145-1161. doi:10.1681/ASN.2016030306

Sung, S. -S. J., Li, L., Huang, L., Lawler, J., Ye, H., Rosin, D. L., . . . Okusa, M. D. (2017). Proximal Tubule CD73 Is Critical in Renal Ischemia-Reperfusion Injury Protection. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 28(3), 888-902. doi:10.1681/ASN.2016020229

Inoue, T., Rosin, D. L., & Okusa, M. D. (2016). CAPing inflammation and acute kidney injury. KIDNEY INTERNATIONAL, 90(3), 462-465. doi:10.1016/j.kint.2016.07.009

Inoue, T., Abe, C., Sung, S. -S. J., Moscalu, S., Jankowski, J., Huang, L., . . . Okusa, M. D. (2016). Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR⁺ splenocytes. JOURNAL OF CLINICAL INVESTIGATION, 126(5), 1939-1952. doi:10.1172/JCI83658

Perry, H. M., Huang, L., Ye, H., Liu, C., Sung, S. -S. J., Lynch, K. R., . . . Okusa, M. D. (2016). Endothelial Sphingosine 1-Phosphate Receptor-1 Mediates Protection and Recovery from Acute Kidney Injury. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 27(11), 3383-3393. doi:10.1681/ASN.2015080922

2015

Bajwa, A., Huang, L., Kurmaeva, E., Gigliotti, J. C., Ye, H., Miller, J., . . . Okusa, M. D. (2016). Sphingosine 1-Phosphate Receptor 3-Deficient Dendritic Cells Modulate Splenic Responses to Ischemia-Reperfusion Injury. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 27(4), 1076-1090. doi:10.1681/ASN.2015010095

Scindia, Y., Dey, P., Thirunagari, A., Huang, L., Rosin, D. L., Floris, M., . . . Swaminathan, S. (2015). Hepcidin Mitigates Renal lschemia-Reperfusion Injury by Modulating Systemic Iron Homeostasis. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 26(11), 2800-2814. doi:10.1681/ASN.2014101037

Gigliotti, J. C., Huang, L., Bajwa, A., Ye, H., Mace, E. H., Hossack, J. A., . . . Okusa, M. D. (2015). Ultrasound Modulates the Splenic Neuroimmune Axis in Attenuating AKI. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 26(10), 2470-2481. doi:10.1681/ASN.2014080769

2014

Bajwa, A., Rosin, D. L., Chroscicki, P., Lee, S., Dondeti, K., Ye, H., . . . Okusa, M. D. (2015). Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 26(4), 908-925. doi:10.1681/ASN.2013121351

2013

Gigliotti, J. C., Huang, L., Ye, H., Bajwa, A., Chattrabhuti, K., Lee, S., . . . Okusa, M. D. (2013). Ultrasound Prevents Renal Ischemia-Reperfusion Injury by Stimulating the Splenic Cholinergic Anti-Inflammatory Pathway. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 24(9), 1451-1460. doi:10.1681/ASN.2013010084

2012

Li, L., Huang, L., Ye, H., Song, S. P., Bajwa, A., Lee, S. J., . . . Okusa, M. D. (2012). Dendritic cells tolerized with adenosine A_2AR agonist attenuate acute kidney injury. JOURNAL OF CLINICAL INVESTIGATION, 122(11), 3931-3942. doi:10.1172/JCI63170

Bajwa, A., Huang, L., Ye, H., Dondeti, K., Song, S., Rosin, D. L., . . . Okusa, M. D. (2012). Dendritic Cell Sphingosine 1-Phosphate Receptor-3 Regulates Th1-Th2 Polarity in Kidney Ischemia-Reperfusion Injury. JOURNAL OF IMMUNOLOGY, 189(5), 2584-2596. doi:10.4049/jimmunol.1200999

Rosin, D. L., & Okusa, M. D. (2012). Dying Cells and Extracellular Histones in AKI: Beyond a NET Effect?. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 23(8), 1275-1277. doi:10.1681/ASN.2012060615

Scindia, Y., Nackiewicz, D., Dey, P., Szymula, A., Bajwa, A., Rosin, D. L., . . . Bagavant, H. (2012). Activated CD4+ T Cells Target Mesangial Antigens and Initiate Glomerulonephritis. NEPHRON EXPERIMENTAL NEPHROLOGY, 121(1-2), E1-E9. doi:10.1159/000342368

2011

Rosin, D. L., & Okusa, M. D. (2011). Dangers Within: DAMP Responses to Damage and Cell Death in Kidney Disease. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 22(3), 416-425. doi:10.1681/ASN.2010040430

2010

Bajwa, A., Jo, S. -K., Ye, H., Huang, L., Dondeti, K. R., Rosin, D. L., . . . Okusa, M. D. (2010). Activation of Sphingosine-1-Phosphate 1 Receptor in the Proximal Tubule Protects Against Ischemia-Reperfusion Injury. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 21(6), 955-965. doi:10.1681/ASN.2009060662

Bajwa, A., Jo, S. -K., Ye, H., Huang, L., Dondeti, K. R., Rosin, D. L., . . . Okusa, M. D. (2010). ACTIVATION OF PROXIMAL TUBULE SPIIINGOSINE 1-PHOSPHATE RECEPTOR 1 PROTECTS KIDNEYS FROM ISCHEMIA REPERFUSION INJURY INDEPENDENT OF LYMPHOCYTES. AMERICAN JOURNAL OF KIDNEY DISEASES, 55(4), A42. Retrieved from https://www.webofscience.com/