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James Radford Stone

James Radford Stone

Professor of Radiology and Medical Imaging, Radiology and Medical Imaging

Primary Location
PO Box 801339
Primary Phone Number

Bio & Overview

Traumatic Brain Injury (TBI) in the combat environment is a major cause of morbidity and mortality in recent armed conflicts. Dr. Stone’s laboratory currently explores questions related to improving the clinical diagnosis of this disease process in both preclinical models and human subjects. Ongoing preclinical work includes the design and investigation of molecular imaging probes for the detection of acute and chronic effects of TBI. Probes under investigation include those targeting inflammation, caspase-3 activity, and apoptosis. He is also involved with exploring novel ultrasound based approaches for the detection of TBI in a far forward environment. Further, he is involved work exploring neurovascular changes in a preclinical blast TBI model. Human subjects work focuses upon exploring neuroimaging correlates of repetitive low-level blast exposure in military populations. The goals of this work include determining whether military service members in this environment are at risk for development of mild TBI and helping to establish safe stand off limits for low-level blast exposure. Additionally, Dr. Stone is involved with efforts exploring optimization of computational neuroimaging tools for assessment of TBI. Dr. Stone’s work currently receives support from CDMRP/DHP, MRMC, DARPA, BUMED, and GE.

Academic Information

Department
Radiology and Medical Imaging
Academic Title
Associate Professor

Primary Education

  • BS, Biology, Virginia Commonwealth University, 1995
  • PhD, Anatomy and Neurobiology, Medical College of Virginia, Virginia Commonwealth University, 2000
  • MD, Medicine, University of Virginia, 2004

Other Appointments

  • Neuroscience
  • Associate Professor, Neurosurgery

Other Affiliations

  • Member, Cancer Center
  • Associate Professor, BIMS

Research Interests

Traumatic Brain Injury

Research Disciplines

  • Neuroscience

Research Opportunities

  • Neuroscience

PhD Programs

  • Neuroscience

Selected Publications

2024

Stone, J. R., Avants, B. B., Tustison, N. J., Gill, J., Wilde, E. A., Neumann, K. D., . . . Ahlers, S. T. (2024). Neurological Effects of Repeated Blast Exposure in Special Operations Personnel. JOURNAL OF NEUROTRAUMA, 41(7-8), 942-956. doi:10.1089/neu.2023.0309

2022

Vorn, R., Edwards, K. A., Hentig, J., Yun, S., Kim, H. -S., Lai, C., . . . Gill, J. M. (2022). A Pilot Study of Whole-Blood Transcriptomic Analysis to Identify Genes Associated with Repetitive Low-Level Blast Exposure in Career Breachers. BIOMEDICINES, 10(3). doi:10.3390/biomedicines10030690

Wilde, E. A., Wanner, I. -B., Kenney, K., Gill, J., Stone, J. R., Disner, S., . . . Jeromin, A. (2022). A Framework to Advance Biomarker Development in the Diagnosis, Outcome Prediction, and Treatment of Traumatic Brain Injury. JOURNAL OF NEUROTRAUMA, 39(7-8), 436-457. doi:10.1089/neu.2021.0099

Edwards, K. A., Leete, J. J., Smith, E. G., Quick, A., Modica, C. M., Wassermann, E. M., . . . Gill, J. M. (2022). Elevations in Tumor Necrosis Factor Alpha and Interleukin 6 From Neuronal-Derived Extracellular Vesicles in Repeated Low-Level Blast Exposed Personnel. FRONTIERS IN NEUROLOGY, 13. doi:10.3389/fneur.2022.723923

Qing, K., Nie, K., Liu, B., Feng, X., Stone, J. R., Cui, T., . . . Chundury, A. (2022). The Impact of Optic Nerve Movement on Intracranial Radiation Treatment. FRONTIERS IN ONCOLOGY, 12. doi:10.3389/fonc.2022.803329

2021

Edwards, K. A., Greer, K., Leete, J., Lai, C., Devoto, C., Qu, B. -X., . . . Gill, J. M. (2021). Neuronally-derived tau is increased in experienced breachers and is associated with neurobehavioral symptoms. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-97913-0

Haran, F. J., Zampieri, C., Wassermann, E. M., Polejaeva, E., Dell, K. C., LoPresti, M. L., . . . Carr, W. (2021). Chronic Effects of Breaching Blast Exposure on Sensory Organization and Postural Limits of Stability. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 63(11), 944-950. doi:10.1097/JOM.0000000000002266

Tustison, N. J., Cook, P. A., Holbrook, A. J., Johnson, H. J., Muschelli, J., Devenyi, G. A., . . . Avants, B. B. (2021). The ANTsX ecosystem for quantitative biological and medical imaging. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-87564-6

Avants, B. B., Tustison, N. J., & Stone, J. R. (2021). Similarity-driven multi-view embeddings from high-dimensional biomedical data. NATURE COMPUTATIONAL SCIENCE, 1(2), 143-152. doi:10.1038/s43588-021-00029-8

Bailes, J. E., Bramlett, H. M., Brody, D. L., Buki, A., Bullock, R., Dietrich, W. D., . . . Vink, R. B. (2021). Tribute to John T. Povlishock, PhD TRIBUTE. JOURNAL OF NEUROTRAUMA, 38(14), 1890-1903. doi:10.1089/neu.2021.29113.jtp.tribute

2020

Stone, J. R., Avants, B. B., Tustison, N. J., Wassermann, E. M., Gill, J., Polejaeva, E., . . . Ahlers, S. T. (2020). Functional and Structural Neuroimaging Correlates of Repetitive Low-Level Blast Exposure in Career Breachers. JOURNAL OF NEUROTRAUMA, 37(23), 2468-2481. doi:10.1089/neu.2020.7141

Dickstein, D. L., De Gasperi, R., Gama Sosa, M. A., Perez-Garcia, G., Short, J. A., Sosa, H., . . . Elder, G. A. (2021). Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure. MOLECULAR PSYCHIATRY, 26(10), 5940-5954. doi:10.1038/s41380-020-0674-z

Modica, C. M., Johnson, B. R., Zalewski, C., King, K., Brewer, C., King, J. E., . . . Carr, W. (2020). Hearing Loss and Irritability Reporting Without Vestibular Differences in Explosive Breaching Professionals. FRONTIERS IN NEUROLOGY, 11. doi:10.3389/fneur.2020.588377

2019

Abutarboush, R., Gu, M., Kawoos, U., Mullah, S. H., Chen, Y., Goodrich, S. Y., . . . Ahlers, S. T. (2019). Exposure to Blast Overpressure Impairs Cerebral Microvascular Responses and Alters Vascular and Astrocytic Structure. JOURNAL OF NEUROTRAUMA, 36(22), 3138-3157. doi:10.1089/neu.2019.6423

Bigler, E. D., Abildskov, T. J., Eggleston, B., Taylor, B. A., Tate, D. F., Petrie, J. A., . . . Wilde, E. A. (2019). Structural neuroimaging in mild traumatic brain injury: A chronic effects of neurotrauma consortium study. INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, 28(3). doi:10.1002/mpr.1781

Cao, R., Zhang, C., Mitkin, V. V., Lankford, M. F., Li, J., Zuo, Z., . . . Hu, S. (2019). Comprehensive Characterization of Cerebrovascular Dysfunction in Blast Traumatic Brain Injury Using Photoacoustic Microscopy. JOURNAL OF NEUROTRAUMA, 36(10), 1526-1534. doi:10.1089/neu.2018.6062

Hsu, A., Bhattacharya, K. R., Chan, H. K., Huber, T. C., Gardner, B., Stone, J. R., & Angle, J. F. (2019). Effect of timing on endovascular therapy and exploratory laparotomy outcome in acute mesenteric ischemia. ANNALS OF GASTROENTEROLOGY, 32(6), 600-604. doi:10.20524/aog.2019.0419

Tustison, N. J., Holbrook, A. J., Avants, B. B., Roberts, J. M., Cook, P. A., Reagh, Z. M., . . . Yassa, M. A. (2019). Longitudinal Mapping of Cortical Thickness Measurements: An Alzheimer's Disease Neuroimaging Initiative-Based Evaluation Study. JOURNAL OF ALZHEIMERS DISEASE, 71(1), 165-183. doi:10.3233/JAD-190283

2018

Bigler, E. D., Skiles, M., Wade, B. S. C., Abildskov, T. J., Tustison, N. J., Scheibel, R. S., . . . Wilde, E. A. (2020). FreeSurfer 5.3 versus 6.0: are volumes comparable? A Chronic Effects of Neurotrauma Consortium study. BRAIN IMAGING AND BEHAVIOR, 14(5), 1318-1327. doi:10.1007/s11682-018-9994-x

2017

Wilkins, L. R., Stone, J. R., Mata, J., Hawrylack, A., Kubicka, E., & Brautigan, D. L. (2017). The Use of the Woodchuck as an Animal Model for Evaluation of Transarterial Embolization. JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 28(10), 1467-1471. doi:10.1016/j.jvir.2017.04.005

Hohenwalter, E. J., Stone, J. R., O'Moore, P. V., Smith, S. J., Selby, J. B., Lewandowski, R. J., . . . Rilling, W. S. (2017). Multicenter Trial of the VenaTech Convertible Vena Cava Filter. JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 28(10), 1353-1362. doi:10.1016/j.jvir.2017.06.032

Huber, T., Wilkins, L. R., Sabri, S., Park, A. W., Stone, J. R., Angle, J. F., . . . Matsumoto, A. H. (2017). Midterm Follow-up of Ureteral Embolization Using Vascular Plugs and N-Butyl Cyanoacrylate Glue. JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 28(8), 1123-1128. doi:10.1016/j.jvir.2017.02.026

2016

Perez-Garcia, G., Sosa, M. A. G., De Gasperi, R., Lashof-Sullivan, M., Maudlin-Jeronimo, E., Stone, J. R., . . . Elder, G. A. (2018). Chronic post-traumatic stress disorder-related traits in a rat model of low-level blast exposure. BEHAVIOURAL BRAIN RESEARCH, 340, 117-125. doi:10.1016/j.bbr.2016.09.061

Dickstein, D. L., Pullman, M. Y., Fernandez, C., Short, J. A., Kostakoglu, L., Knesaurek, K., . . . Gandy, S. (2016). Cerebral [18F]T807/AV1451 retention pattern in clinically probable CTE resembles pathognomonic distribution of CTE tauopathy. TRANSLATIONAL PSYCHIATRY, 6. doi:10.1038/tp.2016.175

Carr, W., Stone, J. R., Walilko, T., Young, L. A., Snook, T. L., Paggi, M. E., . . . Ahlers, S. T. (2016). Repeated Low-Level Blast Exposure: A Descriptive Human Subjects Study. MILITARY MEDICINE, 181(5), 28-39. doi:10.7205/MILMED-D-15-00137

Wilde, E. A., Bigler, E. D., Huff, T., Wang, H., Black, G. M., Christensen, Z. P., . . . Tate, D. F. (2016). Quantitative structural neuroimaging of mild traumatic brain injury in the Chronic Effects of Neurotrauma Consortium (CENC): Comparison of volumetric data within and across scanners. BRAIN INJURY, 30(12), 1442-1451. doi:10.1080/02699052.2016.1219063

Stone, J. R., Wilde, E. A., Taylor, B. A., Tate, D. F., Levin, H., Bigler, E. D., . . . Tustison, N. J. (2016). Supervised learning technique for the automated identification of white matter hyperintensities in traumatic brain injury. BRAIN INJURY, 30(12), 1458-1468. doi:10.1080/02699052.2016.1222080

Perez-Garcia, G., Sosa, M. A. G., De Gasperi, R., Lashof-Sullivan, M., Maudlin-Jeronimo, E., Stone, J. R., . . . Elder, G. A. (2016). Exposure to a Predator Scent Induces Chronic Behavioral Changes in Rats Previously Exposed to Low-level Blast: Implications for the Relationship of Blast-Related TBI to PTSD. FRONTIERS IN NEUROLOGY, 7. doi:10.3389/fneur.2016.00176

2015

Wilde, E. A., Bouix, S., Tate, D. F., Lin, A. P., Newsome, M. R., Taylor, B. A., . . . York, G. (2015). Advanced neuroimaging applied to veterans and service personnel with traumatic brain injury: state of the art and potential benefits. BRAIN IMAGING AND BEHAVIOR, 9(3), 367-402. doi:10.1007/s11682-015-9444-y

Contrella, B. N., Sabri, S. S., Tracci, M. C., Stone, J. R., Kern, J. A., Upchurch, G. R., . . . Angle, J. F. (2015). Outcomes of Coverage of the Left Subclavian Artery during Endovascular Repair of the Thoracic Aorta. JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 26(11), 1609-1614. doi:10.1016/j.jvir.2015.07.022

Stone, J. R., & Wilkins, L. R. (2015). Acute mesenteric ischemia.. Techniques in vascular and interventional radiology, 18(1), 24-30. doi:10.1053/j.tvir.2014.12.004

Wintermark, M., Coombs, L., Druzgal, T. J., Field, A. S., Filippi, C. G., Hicks, R., . . . Provenzale, J. M. (2015). Traumatic Brain Injury Imaging Research Roadmap. AMERICAN JOURNAL OF NEURORADIOLOGY, 36(3), E12-E23. doi:10.3174/ajnr.A4254

Stone, J. R., & Sabri, S. S. (2015). Introduction. TECHNIQUES IN VASCULAR AND INTERVENTIONAL RADIOLOGY, 18(1), 1. doi:10.1053/j.tvir.2014.12.001

Stone, J. R., & Wilkins, L. R. (2015). Acute Mesenteric Ischemia. TECHNIQUES IN VASCULAR AND INTERVENTIONAL RADIOLOGY, 18(1), 24-30. doi:10.1053/j.tvir.2014.12.004

Elder, G. A., Sosa, M. A. G., De Gasperi, R., Stone, J. R., Dickstein, D. L., Haghighi, F., . . . Ahlers, S. T. (2015). Vascular and inflammatory factors in the pathophysiology of blast-induced brain injury. FRONTIERS IN NEUROLOGY, 6. doi:10.3389/fneur.2015.00048

2014

Wilkins, L. R., & Stone, J. R. (2015). Chronic Mesenteric Ischemia. TECHNIQUES IN VASCULAR AND INTERVENTIONAL RADIOLOGY, 18(1), 31-37. doi:10.1053/j.tvir.2014.12.005

Sabri, S. S., Hendricks, N., Stone, J., Tracci, M. C., Matsumoto, A. H., & Angle, J. F. (2015). Retrograde Pedal Access Technique for Revascularization of Infrainguinal Arterial Occlusive Disease. JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 26(1), 29-38. doi:10.1016/j.jvir.2014.10.008

Gandy, S., Ikonomovic, M. D., Mitsis, E., Elder, G., Ahlers, S. T., Barth, J., . . . DeKosky, S. T. (2014). Chronic traumatic encephalopathy: clinical-biomarker correlations and current concepts in pathogenesis. MOLECULAR NEURODEGENERATION, 9. doi:10.1186/1750-1326-9-37

Hendricks, N. J., Matsumoto, A. H., Angle, J. F., Baheti, A., Sabri, S. S., Park, A. W., . . . Cutlip, D. E. (2014). Is fibromuscular dysplasia underdiagnosed? A comparison of the prevalence of FMD seen in CORAL trial participants versus a single institution population of renal donor candidates. VASCULAR MEDICINE, 19(5), 363-367. doi:10.1177/1358863X14544715

Tustison, N. J., Cook, P. A., Klein, A., Song, G., Das, S. R., Duda, J. T., . . . Avants, B. B. (2014). Large-scale evaluation of ANTs and FreeSurfer cortical thickness measurements. NEUROIMAGE, 99, 166-179. doi:10.1016/j.neuroimage.2014.05.044

Elder, G. A., Stone, J. R., & Ahlers, S. T. (2014). Effects of low-level east exposure on the nervous system: is there really a controversy?. FRONTIERS IN NEUROLOGY, 5. doi:10.3389/fneur.2014.00269

Banizs, A. B., Huang, T., Dryden, K., Berr, S. S., Stone, J. R., Nakamoto, R. K., . . . He, J. (2014). In vitro evaluation of endothelial exosomes as carriers for small interfering ribonucleic acid delivery. INTERNATIONAL JOURNAL OF NANOMEDICINE, 9, 4223-4230. doi:10.2147/IJN.S64267

2013

Rueb, G. R., Brady, W. J., Gilliland, C. A., Patrie, J. T., Saad, W. E., Sabri, S. S., . . . Angle, J. F. (2013). Characterizing Cardiopulmonary Arrest during Interventional Radiology Procedures. JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 24(12), 1774-1778. doi:10.1016/j.jvir.2013.07.017

Choudhri, A. F., Norton, P. T., Carr, T. M. I. I. I., Stone, J. R., Hagspiel, K. D., & Dake, M. D. (2013). Diagnosis and treatment planning of acute aortic emergencies using a handheld DICOM viewer. EMERGENCY RADIOLOGY, 20(4), 267-272. doi:10.1007/s10140-013-1118-8

2012

Tustison, N. J., Avants, B. B., Cook, P. A., Kim, J., Whyte, J., Gee, J. C., & Stone, J. R. (2014). Logical circularity in voxel-based analysis: Normalization strategy may induce statistical bias. HUMAN BRAIN MAPPING, 35(3), 745-759. doi:10.1002/hbm.22211

Saad, W. E. A., Kalagher, S., Turba, U. C., Sabri, S. S., Park, A. -W., Stone, J., . . . Matsumoto, A. H. (2013). Ureteric Embolization for Lower Urinary Tract Fistulae: Use of Two Amplatzer Vascular Plugs and N-Butyl Cyanoacrylate Employing the "Sandwich" Technique. CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 36(4), 1068-1072. doi:10.1007/s00270-012-0510-1

Ahlers, S. T., Vasserman-Stokes, E., Shaughness, M. C., Hall, A. A., Shear, D. A., Chavko, M., . . . Stone, J. R. (2012). Assessment of the effects of acute and repeated exposure to blast overpressure in rodents: toward a greater understanding of blast and the potential ramifications for injury in humans exposed to blast.. Frontiers in neurology, 3, 32. doi:10.3389/fneur.2012.00032

2011

Choudhri, A. F., Carr, T. M. I. I. I., Ho, C. P., Stone, J. R., Gay, S. B., & Lambert, D. L. (2012). Handheld Device Review of Abdominal CT for the Evaluation of Acute Appendicitis. JOURNAL OF DIGITAL IMAGING, 25(4), 492-496. doi:10.1007/s10278-011-9431-9