Crowe, Sheila E.
- BS, Genetics and Microbiology, University of Toronto (Trinity College)
- MD, Medicine, McMaster University
- Internship, Medicine, McMaster University
- Residency, Internal Medicine, McMaster University
Immune-epithelial interactions in mucosal inflammation
Currently, Dr. Crowe is pursuing two main projects. The first project is investigating the mechanisms whereby oxidative stress regulates the expression of genes in gastric epithelial cells during infection with H. pylori. These studies entail a characterization of the role of AP endonuclease in redox-sensitive expression of IL-8 and other genes that control inflammation.
In the second project, Dr. Crowe is using mouse models of gastric cancer to study the impact of inflammation and oxidative stress in the control of epithelial cell growth and differentiation. This model also has relevance to the pathogenesis of cancer associated with other forms of inflammation including ulcerative colitis and celiac disease.