Scott Heysell, MD, MPH

• D43TW012247-“Developing research leaders at the intersection of tuberculosis and malnutrition in Tanzania.” Funding Agency: NIH/Fogarty International Center; This Global Infectious Diseases Research Training program will support post-doctoral scientists from Tanzania as content leaders in one or more domains of malnutrition-related TB that will lead their team, compete for independent funding, set research agendas, make policy, and benefit their communities in line with the End TB Strategy.
• Project: U01 AI150508-“A randomized clinical trial of early empiric anti-Mycobacterium tuberculosis therapy for sepsis in sub-Saharan Africa” Funding Agency: NIH/NIAID; The “ATLAS” randomized clinical trial of immediate and/or high dose anti-TB therapy for HIV related sepsis in Tanzania and Uganda will test the optimal treatment, timing, and content of anti-microbial therapy for sepsis in sub-Saharan Africa, which shoulders the highest burden of sepsis in the world.
• Project: R01 AI137080-“Urine colorimetry for tuberculosis pharmacokinetics evaluation in children and adults” Funding Agency: NIH/NIAID. This project will develop urine-based assays for quantification of drug concentrations and triggers for dose adjustment in children treated for tuberculosis in Tanzania and adults with diabetes and tuberculosis in Virginia and New Jersey.
• Project: R01 HL 155547-“Mycobacterial lung diseases in Virginia: sequencing and clinical determinants of relapse and outcome.” Funding Agency: NIH/NHLBI; (PI, Houpt, UVA). In this project, we are performing a statewide survey of environmental and host genome sequencing of mycobacterial isolates, biofilm susceptibility, and pharmacokinetics/pharmacodynamics-informed outcomes determination.
• Project:TMA-2016-SF-1463 “Research Capacity Strengthening Programme for Emerging and Re-emerging Infectious Diseases Control in Tanzania-REMODEL TZ” Funding Agency: European and Developing Countries Clinical Trials Partnerships; (PI Mpagama, Kibong’oto Infectious Diseases Hospital Tanzania). This project is aimed to develop research capacity while performing a randomized controlled trial of n-acetylcysteine for ototoxicity prevention in MDR-TB treatment in Tanzania.
• Project: DANIDA 17-03-KU, “Halting the dual Tuberculosis and Diabetes Epidemic in Tanzania,” Funding Agency: Danida Fellowship Centre, Ministry of Foreign Affairs Denmark; (PI: Christensen, U Copenhagen). This is a large-scale implementation project of dual diabetes and tuberculosis management in three regions in Tanzania, including enhanced screening and linkage to care, optimized management including personalized TB dosing, and training of front-line health care providers and senior researchers.
• Project: “Clofazimine for drug-resistant mycobacterial infections,” Funding Agency: Virginia Tuberculosis Foundation. This is an observational study of the IND, clofazimine, in patients at UVA for drug-resistant mycobacterial infections.
• K24 AI187675- “A global infectious diseases framework to grow interdisciplinary research” Funding Agency: NIH/NIAID; This mid-career development award facilitates Heysell’s group to train junior faculty in collaborative global health research across disciplines and within existing partnered institutional agreements.

RESEARCH AREAS:

• Tuberculosis
• HIV
• Pharmacology
• Clinical Trials
• Equity Interventions
• Global Health Education

Pub Med

• Pharmacokinetic-pharmacodynamic determinants of clinical outcomes for rifampin-resistant tuberculosis: a multi-site prospective cohort study – PubMed (nih.gov)
• Enteropathogen spectrum and effect on antimycobacterial pharmacokinetics among children with tuberculosis in rural Tanzania: a prospective cohort study – PubMed (nih.gov)
• Implementation of a Mobile Health Strategy to Improve Linkage to and Engagement with HIV Care for People Living with HIV, Tuberculosis, and Substance Use in Irkutsk, Siberia – PubMed (nih.gov)
• Leveraging Clinical Decision Support for Racial Equity: A Sociotechnical Innovation | Catalyst non-issue content (nejm.org)

While working in both Tanzania and Uganda, Ms. Null is a Research Specialist and lives most of the time in Moshi, Tanzania. Ms. Null has more than a decade of laboratory bench research and administrative experience working with many partners in East Africa. She administers the ATLAS randomized control trial and the D43 postdoctoral training grant.

Ms. Rao is a Laboratory Specialist. She holds a bachelor’s degree in Biotechnology from India and a Masters in Clinical Pharmacology from The Ohio State University. Prakruti is part of a team that tests the feasibility of alternative assays for therapeutic drug monitoring. Her other focus involves performing pharmacokinetic modeling and simulation in unique tuberculosis datasets to determine optimum treatment regimens.

Dr. Ilaiwy is a Research Associate in Infectious Diseases. Originally from Syria, Dr. Ilaiwy completed his medical degree at the Damascus University Faculty of Medicine. He then moved to the United States for residency, where he completed his training in Internal Medicine at Georgetown’s Medstar Washington Hospital Center and a Masters in Public Health MPH from the Johns Hopkins Bloomberg School of Public Health, where he became interested in economic evaluation and cost-effectiveness in healthcare. Dr. Ilaiwy completed his Infectious Diseases Clinical Fellowship in 2024 with both Drs. Scott Heysell and Tania Thomas in interventional strategies and cost-effective analyses for tuberculosis prevention and improved case in high burden settings. In his spare time, he enjoys the company of friends, hiking in Virginia’s Blue Ridge Mountains, and traveling.

Ms. James is a medical student at the University of Virginia. She received a G.E.R.M. scholarship to work in Tanzania on a project to personalize tuberculosis treatment.

Mr. Reed is an undergraduate at the University of Virginia. He is a laboratory technician working with samples from the PEE-TB project.

Tania Thomas, MD MPH

Christopher C. Moore, MD

Sula Mazimba, MD

Eric Houpt, MD

Margaret Kosek, MD

• Kilimanjaro Clinical Research Institute, Tanzania
• Kibong’oto Infectious Diseases Hospital, Tanzania
• Mbarara University of Science and Technology, Uganda
• Nelson Mandela African Institute of Science and Technology, Arusha, Tanzania
• Haydom Global Health Research Centre
• NIH/Fogarty
• icddr,b – Emerging and re-emerging infections (icddrb.org)
• Global Infectious Diseases Research Training Programs/ NIH Fogarty International Centerà
• Fogarty International Center (nih.gov)
• Center for Global Health Equity

This UVA Speaks podcast features Scott Heysell, the Thomas H. Hunter, Associate Professor of International Medicine and Director of the Center for Global Health Equity at the University of Virginia. Dr. Heysell is an active clinician and researcher who supports partners worldwide in reducing tuberculosis-related deaths. He describes the work of UVA’s Center for Global Health Equity, which offers interdisciplinary research and clinical training opportunities across various global locations like Rwanda, South Africa, India, Nicaragua, and Southwest Virginia. In collaboration with their international partners, Heysell and the Center’s clinicians and researchers seek to dismantle structures of inequity and marginalization, respond to community needs, and build more equitable and effective global healthcare systems.

Scott Heysell, MD, MPH, is the Thomas H. Hunter Associate Professor of International Medicine and Director of the Center for Global Health Equity at UVA Health at the University of Virginia. Dr. Heysell is an active researcher and supports partners worldwide to reduce tuberculosis-related deaths and correct factors that contribute to tuberculosis, including poverty, health system management, and chronic medical conditions such as HIV and diabetes. His research group also studies maximizing drug efficacy to improve treatment outcomes.