David Asuzu, MD, PhD


  • Doctor of Medicine
    Yale School of Medicine, 2017
  • Doctor of Philosophy Physiology and Biomedical Engineering Mayo Clinic, 2011
  • Masters of Public Health Harvard School of Public Health, 2016
  • Bachelor of Science Mechanical Engineering, with distinction Iowa State University, 2005

Research interests

Tumor biology, cancer stem cells, cancer epigenomics, microarray and next-gen sequencing data analysis, functional imaging, brain connectivity, big data, clinical outcomes research, translational studies, product development, resource utilization.

Research experiences

Mayo Clinic, Rochester. 2006 – 2007.
A novel algorithm for correction of MRI motion artifacts in Fourier space.
Mentor: Armando Manduca, Ph.D.

Enteric Neuroscience Unit, Center for Epigonomics. Mayo Clinic, Rochester. 2007 – 2011
Polycomb group proteins as master epigenetic regulators of stem cell senescence in cancer and aging.
Mentor: Tamas Ordog, MD.

Fred Hutchinson Cancer Research Center, Seattle. 2011 – 2012.
Characterization of Dux4, of novel transcription factor targeting rhabdomyosarcoma cell lines.
Mentor: Stephen Tappscott, MD, PhD.

Yale department of Neuroscience.  2012 – 2016
TURN, a simple predictor of hemorrhagic conversion after IV rt-PA
Mentor: Kevin Sheth, MD

Massachusetts General Hospital, department of Neurosurgery. 2016 – 2017
Short and medium term functional outcomes after traumatic brain injury in the TRACK-TBI nationwide database.
Mentor: Ann-Christine Duhaime, MD.

Yale department of Neurosurgery. 2016 – 2017
Clinical, radiographic and pathological characterization of atypical pituitary adenomas.
Mentor: Dennis Spencer, MD.

NIH NINDS department of Neurological Surgery. 2016.
Prediction of early remission after transsphenoidal surgery for Cushing’s disease.
Mentor: Prashant Chittiboina, MD.

Honors and awards

Iowa State University Dean’s list Spring 2003, Fall 2003, Spring 2004
National Dean’s List honor society feature student, 2005
Winner, 2004/2005 William Bathie Mechanical Engineering academic achievement scholarship
2009 AAAS/Science Award for Excellence in Science
2009 NGEM Young Investigator award for poster abstract titled “Polycomb group (PcG) transcriptional co-repressors regulate the differentiation of isolated KitlowCD34+CD44+ progenitors of murine gastric interstitial cells of Cajal (ICC)”
2009 NIH F31 predoctoral research grant Epigenetic regulation of stem cell senescence in aging. National Institute of Diabetes and Digestive and Kidney Diseases F31 DK89974
2013 Lowe Research Funds Award, Yale University School of Medicine
2014 American Academy of Neurology G. Milton Shy Award for achievements in research.
2014 Yale Venture Creation Program Award for Bulldog Mobile Health
2014 Google Developers Startup Launch award for mobile app Risk rtPA
2015 Facebook FbStart award for mobile app Risk rtPA
2015 Yale Farr Scholarship for excellence in research
2018 NIH LRP intramural award. Characterization of cortisol-secreting pituitary adenomas.


Diurnal Range and Intra-patient Variability of ACTH Is Restored With Remission in Cushing's Disease

J Clin Endocrinol Metab. 2023 Oct 18;108(11):2812-2820. doi: 10.1210/clinem/dgad309.ABSTRACTCONTEXT: Single ACTH measurements have limited ability to distinguish patients with Cushing's disease (CD) from those in remission or with other conditions.OBJECTIVE:…

Proteostasis Modulation in Germline Missense von Hippel Lindau Disease

Clin Cancer Res. 2023 Jun 13;29(12):2199-2209. doi: 10.1158/1078-0432.CCR-22-3651.ABSTRACTPURPOSE: Missense mutated von Hippel Lindau (VHL) protein (pVHL) maintains intrinsic function but undergoes proteasomal degradation and tumor initiation and/or progression in VHL…

Cortisol and ACTH Measurements at Extubation From Pituitary Surgery Predicts Hypothalamic-Pituitary-Adrenal Axis Function

J Endocr Soc. 2023 Feb 6;7(4):bvad025. doi: 10.1210/jendso/bvad025. eCollection 2023 Feb 9.ABSTRACTCONTEXT: Early prediction of hypothalamic-pituitary-adrenal (HPA) axis function following transsphenoidal surgery (TSS) can improve patient safety and reduce costs.OBJECTIVE:…

Patient-Reported Outcomes and Predictive Factors following Focused Ultrasound Thalamotomy for Essential Tremor

Stereotact Funct Neurosurg. 2022;100(5-6):291-299. doi: 10.1159/000525763. Epub 2022 Aug 26.ABSTRACTINTRODUCTION: The objectives of this study were to determine long-term patient-reported outcomes with magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy for medication-refractory…

Pituitary adenomas evade apoptosis via noxa deregulation in Cushing's disease

Cell Rep. 2022 Aug 23;40(8):111223. doi: 10.1016/j.celrep.2022.111223.ABSTRACTSporadic pituitary adenomas occur in over 10% of the population. Hormone-secreting adenomas, including those causing Cushing's disease (CD), cause severe morbidity and early mortality.…

Giant pituitary macroadenoma of stem cell origin: illustrative case

J Neurosurg Case Lessons. 2021 Mar 8;1(10):CASE2122. doi: 10.3171/CASE2122. eCollection 2021 Mar 8.ABSTRACTBACKGROUND: Giant pituitary macroadenomas with a diameter >4 cm are rare tumors, accounting for only about 5% of…

Multiple VHL-related hemangioblastomas and holocord syrinx: identifying the causative lesion. Illustrative case

J Neurosurg Case Lessons. 2021 Sep 13;2(11):CASE21296. doi: 10.3171/CASE21296. eCollection 2021 Sep 13.ABSTRACTBACKGROUND: Brainstem and spinal cord hemangioblastomas are a common manifestation of von Hippel-Lindau (VHL) disease. Cysts and associated…

Association of ≥ 12 months of delayed surgical treatment for cervical myelopathy with worsened postoperative outcomes: a multicenter analysis of the Quality Outcomes Database

J Neurosurg Spine. 2021 Nov 5;36(4):568-574. doi: 10.3171/2021.7.SPINE21590. Print 2022 Apr 1.ABSTRACTOBJECTIVE: Degenerative cervical myelopathy (DCM) results in significant morbidity. The duration of symptoms prior to surgical intervention may be…

<em>FGFR1-TACC1</em> fusion associated with malignant transformation in a primary spinal cord glioma: a case report

J Spine Surg. 2021 Sep;7(3):434-438. doi: 10.21037/jss-21-24.ABSTRACTMolecular mechanisms of malignant transformation in spinal cord gliomas are not well-understood. Our objective was to investigate genetic causes of malignant transformation in a…

MAZOR-X robotic-navigated percutaneous C2 screw placement for hangman's fracture: a case report

J Spine Surg. 2021 Sep;7(3):439-444. doi: 10.21037/jss-20-676.ABSTRACTRobotic-navigated screw placement has potential for higher precision and accuracy. Robotic assistance is well-described in the lumbar spine, however only few studies have evaluated…

Clinical and radiologic outcomes after stereotactic radiosurgery for meningiomas in direct contact with the optic apparatus: an international multicenter study

J Neurosurg. 2021 Sep 24;136(4):1070-1076. doi: 10.3171/2021.3.JNS21328. Print 2022 Apr 1.ABSTRACTOBJECTIVE: Resection of meningiomas in direct contact with the anterior optic apparatus carries risk of injury to the visual pathway.…

Routine postoperative fluid restriction to prevent syndrome of inappropriate antidiuretic hormone secretion after transsphenoidal resection of pituitary adenoma

J Neurosurg. 2021 Jul 30;136(2):405-412. doi: 10.3171/2021.1.JNS203579. Print 2022 Feb 1.ABSTRACTOBJECTIVE: Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common problem during the postoperative course after pituitary surgery. Although…

Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging

Cell Mol Gastroenterol Hepatol. 2021;11(1):117-145. doi: 10.1016/j.jcmgh.2020.07.011. Epub 2020 Aug 7.ABSTRACTBACKGROUND & AIMS: Gastric dysfunction in the elderly may cause reduced food intake, frailty, and increased mortality. The pacemaker and…

Fulminant Reversible Cerebral Vasoconstriction Syndrome After Carotid Endarterectomy for Asymptomatic Stenosis

World Neurosurg. 2020 Feb;134:423-426. doi: 10.1016/j.wneu.2019.11.032. Epub 2019 Nov 13.ABSTRACTBACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS) is a rare complication after carotid endarterectomy (CEA). Only a limited number of prior cases…

Craniotomy and direct access microcatheterization for preoperative embolization of a complex, high grade intracranial arteriovenous malformation

J Clin Neurosci. 2019 Oct;68:333-335. doi: 10.1016/j.jocn.2019.05.052. Epub 2019 Jun 11.ABSTRACTThe optimal management of complex, Spetzler-Martin Grade 5 arteriovenous malformations (AVMs) remains a challenge, despite the availability of endovascular, surgical…