Jiang He, PhD
Jiang He, PhD
Associate Professor of Radiology and Medical Imaging
BS, Chemistry, Sichuan University, China, 1991
MS, Chemistry, Chinese Academy of Sciences, China, 1994
PhD, Chemistry, Peking University, China, 1997
Post-Doctorate, Catholic University of Louvain, Belgium, 2001
Post-Doctorate, University of Massachusetts Medical School, 2003
University of Virginia
Department of Radiology and Medical Imaging
Fontaine Research Park
480 Ray C. Hunt Dr., Rm 216
Charlottesville, VA 22903
Office Phone: 434-243-1011
Molecular imaging is an emerging research area aimed at imaging specific molecular signatures – particularly those that are key targets in disease processes. Unlike anatomical imaging, molecular imaging displays the biochemical or physiological abnormalities underlying disease, rather than the structural consequences of these abnormalities. Potential clinical applications of molecular imaging in diagnosis, patient stratification, and therapy response monitoring have been widely recognized in recent years particularly with the explosive advances of highly sensitive and quantitative PET imaging, which uses imaging probes based on positron emitting isotopes.
The research themes in my lab are to develop novel radiotracers for molecular imaging, and to design new biological nanoparticles for combined imaging and therapy applications, in cancer, cardiovascular and neurological disorders from animal studies to clinical use.
Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas. Iyer AK, Lan X, Zhu X, Su Y, Feng J, Zhang X, Gao D, Seo Y, Vanbrocklin HF, Broaddus VC, Liu B, He J. Cancer Res. 2011 Apr 1;71(7):2428-32.
Radiolabeled oligonucleotides for antisense imaging. Iyer AK, He J. Curr Org Synth. 2011 Aug 1;8(4):604-614.
Affinity enhancement pretargeting: synthesis and testing of a 99mTc-labeled bivalent MORF. He J, Wang Y, Dou S, Liu X, Zhang S, Liu G, Hnatowich D. Mol Pharm. 2010 Aug 2;7(4):1118-24.
Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single-chain antibody fragment. He J, Wang Y, Feng J, Zhu X, Lan X, Iyer AK, Zhang N. Seo Y, VanBrocklin HF, Liu B. J Nucl Med. (2010)
Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Bidlingmaier S, He J, Wang Y, An F, Feng J, Barbone D, Gao D, Franc B, Broaddus VC, Liu B. Cancer Res. 2009 Feb 15;69(4):1570-7.
Development of an optimized activatable MMP-14 targeted SPECT imaging probe. Watkins GA, Jones EF, Scott Shell M, VanBrocklin HF, Pan MH, Hanrahan SM, Feng JJ,He J, Sounni NE, Dill KA, Contag CH, Coussens LM, Franc BL. Bioorg Med Chem. 2009 Jan 15;17(2):653-9.