An Overview of Gadolinium Deposition – Is It a Real Concern?
Dr. David F. Kallmes, M.D.
Wednesday, November 18th
This presentation provided a broad overview of tissue deposition of gadolinium, focused on the central nervous system. Preclinical studies provide evidence of the pattern and degree of gadolinium deposition across various agents, as well as some evidence regarding potential clinical and behavioral impact. Many clinical imaging studies provide indirect evidence of gadolinium deposition from T1 shortening, which varies substantially across different agents. Newer studies provide early, indirect evidence of washout. A number of clinical studies, predominantly retrospective, have failed to detect neurologic deficits. The syndrome of “Gadolinium Deposition Disease” was discussed, along with future areas for research and clinical management.
Learning objectives include:
- Understand neuroimaging findings of gadolinium deposition
- Understand relative degrees of deposition for linear versus macrocyclic agents
- Review recent preclinical and clinical studies regarding potential clinical manifestations of gadolinium deposition
- Review the syndrome of Gadolinium Deposition Disease and its impact on routine practice
About the Lecturer
David F. Kallmes, M.D., is a Professor of Radiology at the Mayo Clinic in Rochester, MN. He completed his Fellowship in Diagnostic and Interventional Neuroradiology at UVA.