Tissue microarray technology places up to a thousand discs of tissue on a single glass slide, which can then be assayed by histologic staining, immunohistochemistry and/or in situ hybridization.
For further description of TMA technology, please go here.
The BTRF can create custom TMAs for investigators, using formalin-fixed paraffin-embedded tissue either provided by the investigator, or obtained from the archives of the UVA Pathology Department.
The BTRF has also created a TMA set that surveys 159 common carcinomas. For a description, please go here.
The BTRF collaborates with NCI-sponsored consortia groups to create other TMAs that may be obtained by UVA investigators. For a description of of TMAs, fees and application forms, please follow the links below.
NCI Cooperative Human Tissue Network (CHTN):
TMAs of normal tissues, brain tissues, colon cancer, ovarian cancer, breast cancer, prostate cancer
NCI Cancer Diagnosis Program Tissue Microarrays: (Now distributed by the CHTN)
Highly-annotated breast cancer progression TMAs
Highly-annotated breast cancer prognositic TMAs
Melanoma progression survey TMAs
Other TMA sites of interest: