Cre Flox Flp Mice

(1) Widespread/germline deleter
StrainBackgroundPromoter/Exp.Original SourceLab
Tg(EIIa-Cre)C5379Lmgd/JB6.FVBEIIaJax 003724David Wotton
Tg(MMTV-Cre)4Mam/JB6129F1MMTVJax 003553Tom Parsons
Hsp70-CreHsp70Scott Zeitlin
(2) Inducible
StrainBackgroundPromoter/Exp.Original SourceLab
Tg(Mx1-cre)1Cgn/JB6.CgMx1 (plpC or interferon)Jax 003556Adam Goldfarb
Tg(Cre/Esr1)5Amc/JB6.CgCMV(tamoxifen)Jax 004682Gary Owens Xiaowei Lu Jing Yu
Tg(Sp7-tTA,tetO- EGFP/Cre)1Amc/JB6.CgSp7 (Dox), “Tet-Off”, osteoblastJax 006361Greg Clines
Tg(Atoh1-CreER-IRES-AP)1SbkFVBAtonal homolog 1 (tamoxifen)MMRRC 029581-UNCXiaowei Lu
3 Knock-in
StrainBackgroundPromoter/Exp.Original SourceLab
CD19-CreB6, B6;129, 129CD19Jax 004126Tim Bender
Mb1-CreB6;129;BALB/cMb1Tim Bender
ThB6.129X1Tyrosine hydroxylaseEMMA 00254Ruth Stornetta
Chat/JB6;129S6Choline acetyltransferaseJax 006410Ruth Stornetta
Foxg1tm1(cre)Skm/J129.CgFoxhead box g1Jax 004337Xiaowei Lu
(4) Tissue/cell specific
StrainBackgroundPromoter/Exp.Original SourceLab
SMHC-CreSmooth myosin heavy chainGary Owens
SM22-CreSmooth muscle 22Gary Owens
SMHC-Cre/EGFPSmooth myosin heavy chainGary Owens
Col a1(I)2.3 CreFVBCollagen 1a1Greg Clines
TgN(MCK-Cre)B6.FVBMuscle creatine kinaseThurl Harris
Tg(Fabp4-Cre)1Rev/JB6.CgFatty acid binding protein 4Jax 005069Thurl Harris
CD21-Cre3aB6.Cgimmature mIgM+ mIgD- bone marrow cellsJax 006368Tim Bender
Lck-CreB6;129T-lineage cellsTim Bender
CD4-CreB6;129DN4 and DP thymocytesTim Bender
Distal lck-CreB6;DBAsSP thymocytesTim Bender
IgG alpha-CreB cellTom Parsons
LysM-CreMacrophageTom Parsons
Tg(Alb-Cre)B6.CgAlbuminJax 003574David Wotton
Math1-CreAtonal homolog 1Xiaowei Lu
Tg(Pax2-cre)1AkgCD-1Pax2MMRRC 010560-UNCXiaowei Lu
HB9-CreMotor neuronJeh-Ping Liu
Nestin-CreRat nestinJeh-Ping Liu
Isl1-CreIsl1 txn factorJeh-Ping Liu
CaMKII-Cre (R1, L7, R4)Ca/Cal kinase IIScott Zeitlin
Tg(Sox2-Cre)1Amc/JB6CBASRY-box containing gene 2Jax 004783David Wotton
Tg(Pbsn-Cre)4PrbB6.D2Rat probasinNCI 01XF5Tom Parsons
B6.Cg-Shhtm1(EGFP/cre)Cjt/JB6 congenicLung epitheliumJax 005622John Fu
B6.129X1-Twist2tm1.1(cre)Dor/JB6 congenicMesenchymeJax 008712John Fu
B6.129S-Sftpctm1(cre/ERT2)Blh/JB6 congenicLung alveolar epithelial cells (inducible Cre)Jax 028054Kwon Park
B6N.129S6(Cg)-Scgb1a1tm1(cre/ERT)Blh/JB6N congenicLung Clara cells (inducible Cre)Jax 016225Jax
Tg(Scgb1a1-cre)1TaucB6Lung Clara cellsEM:02464EMMA
(5) Flox
StrainBackgroundPromoter/Exp.Original SourceLab
RUNX1Adam Goldfarb
KLF4Gary Owens
TGFβGary Owens
PDGF β receptorGary Owens
PDGF β chainGary Owens
TGIFDavid Wotton
ETARB6;129Endothelin A receptorGreg Clines
Mybf/f (c-Myb)B6, B6;129Exon IITim Bender
Mybl2f/f (B-Myb)B6;129Exon II-IVTim Bender
RictorThurl Harris
Hoxc8Jeh-Ping Liu
Hoxc6Jeh-Ping Liu
Gt(ROSA)26Sortm1Sor/J129SLoxP-STOP-LoxP-LacZJax 003310Tom Parsons Gary Owens Roy Ogle
Gt(ROSA)26Sortm1(EYFP)/Cos/JB6LoxP-STOP-LoxP-EYFPJax 006148Tom Parsons
Gt(ROSA)26Sortm1(Luc)Kael/JFVB.129S6(B6)LoxP-STOP-LoxP-LuciferaseJax 005125
Id3B6-CgfloxedColeen McNamara
(6) Flp
StrainBackgroundPromoter/Exp.Original SourceLab
Tg(ACTFLPe)9205Dym/JB6.CgHuman β-actinJax 005703Xiaowei Lu
Tg(CAG-FLPo)1Afst/MmucdC57BL/6NCodon-optimized FLPMMRRC 036512-UCDAriel Gomez
Tg(PGK1-FLPo)10Sykr/JB6(C3)Codon-optimized FLPJax 011065Kevin Lynch
Gt(Rosa)26Sortm1(FLP1)Dym/RainJB6.129S4KIJax 009086
(7)Tg/KO Mice
StrainBackgroundPromoter/Exp.Original SourceLab
FVB-Tg(Pbsn-AKT1)9WrsFVBProbasin-AKT1NCI 01XJ7Bryce Paschel
Rho GDI alpha50% 129SV, 25% DBA2, 25% C57BL/6KOJun MiyoshiDan Theodorescu
Rho GDI beta50% 129SV, 25% DBA2, 25% C57BL/6KOJun MiyoshiDan Theodorescu
B6.129P2-Apoetm1Unc/JB6.129KOJax 002052Coleen McNamara
B6.129S-Id3tm1Zhu/JB6.129KOJax 006301Coleen McNamara