IGNITE KUH (pre/post doc)

Kidney, Urology, Hematology Journal Club Series

Administrative Core

The IGNITE KUH Administrative Core will provide a unified and integrated structure, oversight, and governance for the program. Through coordinated communication and continued assessment, we will monitor outcomes and disseminate the work and successes of KUH trainees.

Professional Development Core

The primary goal of the Professional Development Core is to provide career development resources to trainees to facilitate advancement and success in a research career in KUH fields.

Network Core

The primary goal of the Network Core is to develop a statewide program by providing a platform for peer-to-peer mentorship and outreach activities to attract trainees from the three constituent institutions in the Commonwealth of Virginia. It will foster interactions with high school, college, and medical students from under-represented and minority Virginia institutions interested in KUH research.

Training Core

The Training Core will train pre and post-doctoral trainees with career interests in basic, translational, clinical, or data science research into the IGNITE KUH Training Program.

Training Mentors

IGNITE KUH faculty members are from the University of Virginia (UVA), Virginia Commonwealth University (VCU), and Virginia Polytechnic and State University (VT), with expertise in four central areas:

• Hematology
• Kidney biology/disease
• Urology
• Fundamental (basic) sciences (related to hematology, urology, and nephrology)

The UVA research programs focus mainly on kidney disease, hematological disorders, or urological dysfunction using cutting-edge technologies to probe and investigate systems/computational biology, high-throughput spectral flow cytometry, data sciences, and nanoparticle development/delivery systems.

The VCU research programs are focused on hypertension, hematopoiesis, nanomedicine, vascular biology, sickle cell disease, sphingolipid biology, and urological dysfunction.

The VT research programs focus on fundamental aspects of cardiac function, vascular development and function, sepsis, and drug discovery.

High School Students

The Division of Nephrology in the Department of Medicine at UVA offers a research summer program for high school students who are interested in careers in the areas of science and medicine. Each summer 2-3 students are matched with a mentor in our division who runs a laboratory for basic science with a focus on immunology and kidney diseases. Depending on interest and experience the students can take part in a specific research project or shadow the team. The students will also receive some introductory lectures on science and medicine to enrich their learning experience. It is advised that the students work full-time for 4-6 weeks so that they can get good exposure to the world of science and have time to finish a small research project. Interested students should contact Uta Erdbrugger, MD, for more information.

Undergraduate Students

Kidney Technology Development Research Education Program (VA K-TUTOR), the NIH-funded UVA Nephrology R25 training grant (supported by NIDDK grant 1 R25 DK124918) will provide immersive research and education experience for technology-oriented undergraduate students enrolled at the University of Virginia or Virginia Tech to participate in cutting-edge research in nephrology to generate innovative solutions for promoting kidney health. Our goal is to improve the lives of 40 million people in the US with kidney diseases. The VA K-TUTOR will be a partnership with the UVA Division of Nephrology, UVA School of Engineering and Applied Science, UVA College of Arts and Sciences, and Virginia Tech School of Engineering to recruit and train undergraduate students for identifying problems in kidney research and finding novel solutions.

IGNITE KUH is funded by the National Institute of Health (NIH) Grant: 1U2CDK129500-01 (NIH RePORTER) and 1TL1DK132771-01 (NIH RePORTER).

The application can be accessed here. For additional information, contact Lena Garrison.

Pre-Doctoral Application Deadline: April 26, 2024.
Post-Doctoral Application Deadline: open, accepted on a rolling basis.

Our Team

Program Directors

Administrative Team

Eibhlin Goggins, BS
Institution: UVA
Mentor: Mark Okusa, MD
2023-2023

Ebby received her BS in Chemistry (specializing in Biochemistry) from Georgetown University in 2018 and entered the Medical Scientist Training Program at the University of Virginia in 2019; in 2021, after discovering her love for the kidneys, she joined the Okusa Lab as a PhD student. For her first project, Ebby is investigating using pulsed splenic ultrasound to prevent and treat kidney disease. More specifically, her studies involve expanding ultrasound to additional mouse models of kidney disease to understand the clinical utility in different contexts. Additionally, her studies focus on understanding the mechanism behind this kidney protection provided by therapeutic ultrasound.  Her second project focuses on mitochondrial dynamics and specifically the role of the mitochondrial fission protein, Dynamin-Related Protein 1 (Drp1), in kidney perivascular cells (PVCs). Her studies found that reduced PVC Drp1 protects against Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD) in mice. Current work focuses on understanding the effect of timing, cellular expression, and level of Drp1 reduction on AKI/CKD outcomes.

Hillary Montano, BS
Institution: Va Tech
Mentor: Christopher M. Reilly, PhD
2023-2023

Hilary Montano is a PhD student in the Biomedical & Veterinary Science Program at Virginia Polytechnic Institute and State University, Blacksburg, VA. She received her bachelor’s in Biological Sciences at the Virginia Polytechnic Institute and State University, Blacksburg, VA. As an undergraduate, she joined the laboratory of Dr. Anne Zajac where she worked on Bacillus thuringiensis and the Cry5b protein. After that, she became a research assistant in the laboratory of Dr. Raj Gaji, where she studied Toxoplasma gondii including experiments using CRISPR/Cas9 technology. Recently, she joined Dr. Chris Reilly‘s laboratory and became interested in studying Systemic Lupus Erythematosus (SLE), an autoimmune disease in which individuals often develop lupus nephritis. Lupus nephritis is a leading cause of mortality among individuals with SLE.  Her current research is focused on elucidating the role of NF-KB-Inducing Kinase (NIK) in the non-canonical NF-KB pathway in the disease progression of SLE. She will conduct laboratory-based and preclinical studies to understand further the contribution of the non-canonical NF-KB pathway in lupus-prone mice.

Elizabeth Thompson, BS
Institution: UVA
Mentor: Julia Scialla, MD, MSc
2023-2023

Elizabeth Thompson is a PhD student in Systems and Information Engineering at the School of Engineering & Applied Sciences, University of Virginia. She earned her bachelor’s degree in Psychology from the School of Humanities and Social Sciences, Worcester State University, Worcester MA, and she completed her master’s in Clinical Counseling Psychology at Assumption College, Worcester MA. Before beginning her PhD, she also spent two years studying Computer Science as an undergraduate at the School of Computing and Informational Sciences, University of Maine, Orono, ME. With a computer science and psychology background, Liz has worked with vulnerable populations as a clinician for several years. Recently, she completed an En Route Master of Engineering (M.E.) in Systems and Information Engineering.  She aims to gain the knowledge and skills needed to engage in research to improve treatment outcomes for individuals with chronic kidney disease (CKD). Her current research involves utilizing Machine Learning and Reinforcement Learning to develop a bias-aware AI (Artificial Intelligence) program for precision treatment of CKD-MBD (Mineral Bone Disease). Bias is a significant concern in healthcare AI and, in some cases, has worked to increase the current healthcare disparity gap.

Jason Burchett, BS
Institution: VCU
Project: Fluoxetine suppresses mast cell-mediated inflammatory disease
Mentor: James Ryan, PhD
2021-2023

Kennedy Goldsborough, BS
Institution: VCU
Project: Targeting the endogenous cannabinoid system in Sickle Cell
Mentor: Aron Lichtman, PhD
2021-2023

Kristin Kim, BS
Institution: VCU
Project: The role of cell-extracellular matrix crosstalk in mediating the progression of fibrosis in a 3D culture model
Mentor: Christopher Lemmon, PhD
2021-2023

Eva Otoupalova, PhD (UVA)
Institution: UVA
Mentor: Jeff Sturek, MD
2023-2024

Dr. Eva Otoupalova received her medical degree from Charles University in Prague. Following graduation, she trained in basic laboratory methods, studying mechanisms of fibroblast senescence at the University of Alabama (UAB). She then pursued a residency in Internal Medicine at Oakland University and returned to UAB as an Assistant Professor of Medicine, attending the Pulmonary and Ventilator weaning unit. She recently completed a 2-year clinical fellowship at the University of Virginia, Division of Pulmonary and Critical Care. Her project will investigate whether HIV and HIV/TB co-infection leads to dysregulated emergency myelopoiesis in sepsis, altered myeloid/lymphoid lineage, and B- and T-cell development. She will utilize samples collected and banked within the ATLAS trial, a randomized multicenter trial of early anti-TB therapy versus standard antibiotic therapy in patients with HIV admitted with sepsis in Tanzania and Uganda. This provides a unique cohort of highly characterized sepsis phenotypes in HIV patients.

Vikram Sabapathy, PhD (UVA)
Institution: UVA
Mentor: Rahul Sharma, PhD
2023-2024

Vikram earned his PhD from the Centre for Stem Cell Research (CSCR) at Christian Medical College, Vellore. His doctoral research, conducted under the guidance of Dr. Sanjay Kumar, focused on several key areas, including the examination of perinatal Mesenchymal Stem Cells (MSC), the creation of safer human induced Pluripotent Stem Cells (iPSCs), and the application of tissue engineering techniques for translational purposes. Specifically, he was deeply interested in delving into the intricate aspects of cellular reprogramming, tissue rejuvenation, and regeneration. After completing his PhD, Vikram became a Research Associate in the laboratory of Dr. Rahul Sharma at the Center of Immunity, Inflammation, and Regenerative Medicine (CIIR) at the University of Virginia. Here, his primary goal was to gain insight into the immune system’s role in regenerative medicine. The immune system poses a significant challenge for the translational application. The role of immune cells in tissue development, repair, and regeneration is poorly understood. Currently, Vikram is actively investigating the significance of IL-33/ST2 ‘alarmin’ signaling axis in activation and mobilizing immune cells using murine models of kidney injury and kidney organoids.

Ashley Anderson, PhD
Institution: UVA
Project: Environmental antigens, Cross-reactive T cells, and autoimmunity
Mentor: Shu Man Fu, MD, PhD
2021-2023

Blake Caldwell, PhD
Institution: VT
Project: Epigenetic regulation of innate immune exhaustion
Mentor: Liwu Li, PhD
2022-present

Vikram Sabapathy, PhD
Institution: UVA
Project: IL2-33 Hybrid Cytokine in Kidney Disease
Mentor: Rahul Sharma, PhD
2021-2023

Vikram earned his PhD from the Centre for Stem Cell Research (CSCR) at Christian Medical College, Vellore. His doctoral research, conducted under the guidance of Dr. Sanjay Kumar, focused on several key areas, including the examination of perinatal Mesenchymal Stem Cells (MSC), the creation of safer human induced Pluripotent Stem Cells (iPSCs), and the application of tissue engineering techniques for translational purposes. Specifically, he was deeply interested in delving into the intricate aspects of cellular reprogramming, tissue rejuvenation, and regeneration. After completing his PhD, Vikram became a Research Associate in the laboratory of Dr. Rahul Sharma at the Center of Immunity, Inflammation, and Regenerative Medicine (CIIR) at the University of Virginia. Here, his primary goal was to gain insight into the immune system’s role in regenerative medicine. The immune system poses a significant challenge for the translational application. The role of immune cells in tissue development, repair, and regeneration is poorly understood. Currently, Vikram is actively investigating the significance of IL-33/ST2 ‘alarmin’ signaling axis in activation and mobilizing immune cells using murine models of kidney injury and kidney organoids.

Jennifer Sasson, MD, MSCR
Institution: UVA
Project: Acute and Long-Term Implications of IL-13 in COVID-19 Associated Hypoxic Respiratory Failure
Mentor: William Petri, MD, PhD
2021-2022