Publications

Babcock IW, Labuzan SA, Kelly AG, Schuster AE, Alemu S, Sibley LA, Marchildon AE, Harris TH. Enhancing the specificity of microglia genetic targeting using a CSF1R inhibitor. Cell Rep. 2026 Jun 23;45(6):117411. doi: 10.1016/j.celrep.2026.117411. Epub 2026 May 30. PMID: 42217186.

Sibley LA, Babcock IW, Amadi ND, Marchildon AE, Kelly AG, Labuzan SA, Lukens JR, Harris TH. ZBP1 mediated restriction of Toxoplasma gondii in both the early acute and chronic brain stages of infection. Immunohorizons. 2026 Apr 11;10(4):vlag015. doi: 10.1093/immhor/vlag015. PMID: 41999653; PMCID: PMC13091654.

Sibley LA, Cowan MN, Kelly AG, Amadi NA, Babcock IW, Labuzan SA, Kovacs MA, Batista SJ, Lukens JR, Harris TH. Caspase-8 expression in CD8⁺ T cells promotes pathogen restriction in the brain during Toxoplasma gondii infection. Sci Adv. 2025 Dec 12;11(50):eadz4468. doi: 10.1126/sciadv.adz4468. Epub 2025 Dec 12. PMID: 41385623; PMCID: PMC12700200.

Babcock IW, Sibley LA, Harris TH. Cell death in the brain during parasitic infections. J Immunol. 2025 Aug 1;214(8):1881-1888. doi: 10.1093/jimmun/vkaf128. PMID: 40878574.

Babcock IW, Sibley LA, Labuzan SA, Cowan MN, Sethi I, Alemu S, Kelly AG, Kovacs MA, Lukens JR, Harris TH. Caspase-1 in Cx3cr1-expressing cells drives an IL-18-dependent T cell response that promotes parasite control during acute Toxoplasma gondii infection. PLoS Pathog. 2024 Oct 24;20(10):e1012006. doi: 10.1371/journal.ppat.1012006. PMID: 39446964; PMCID: PMC11537422.

Kovacs MA, Cowan MN, Babcock IW, Sibley LA, Still K, Batista SJ, Labuzan SA, Sethi I, Harris TH. Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain. Elife. 2022 Dec 21;11:e80775. doi: 10.7554/eLife.80775. PMID: 36541708; PMCID: PMC9812409.

Cowan MN, Kovacs MA, Sethi I, Babcock IW, Still K, Batista SJ, O’Brien CA, Thompson JA, Sibley LA, Labuzan SA, Harris TH. Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis. PLoS Pathog. 2022 Sep 6;18(9):e1010637. doi: 10.1371/journal.ppat.1010637. PMID: 36067217; PMCID: PMC9481170.

Still KM, Batista SJ, O’Brien CA, Oyesola OO, Früh SP, Webb LM, Smirnov I, Kovacs MA, Cowan MN, Hayes NW, Thompson JA, Tait Wojno ED, Harris TH. Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling. PLoS Pathog. 2020 Oct 27;16(10):e1009027. doi: 10.1371/journal.ppat.1009027. PMID: 33108405; PMCID: PMC7647122.

Batista SJ, Still KM, Johanson D, Thompson JA, OʼBrien CA, Lukens JR, Harris TH. Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection. Nat Commun. 2020 Jul 23;11(1):3687. doi: 10.1038/s41467-020-17491-z. PMID: 32703941; PMCID: PMC7378823.

O’Brien, C. A., S. J. Batista, K. M. Still, and T. H. Harris. 2018. IL-10 and ICOS differentially regulate T cell response in the brain during chronic Toxoplasma gondii infection. J Immunol. In press. 2019.

Louveau, A., J. Herz, M. Alme, A. Salvador, M. Dong, K. Viar, G. Herod, J. Knopp, J. Setliff, A. Lupi, S. Da Mesquita, E. Frost, A. Gaultier, T. H. Harris, R. Cao, S. Hu, J. R. Lukens, I. Smirnov, C. Overall, G. Oliver, and J. Kipnis. CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.  Nat Neurosci. 21: 1380-1391, 2018.

Ly, T., J. A. Thompson, T. H. Harris, and S. T. Acton. The coupled TuFF-BFF Algorithm for Automatic 3D Segmentation of Microglia. 2018 25th IEEE International Conference on Image Processing (ICIP). 121-125, 2018.

Norris, G. T., I. Smirnov, A. J. Filiano, H. Shadowen, K. Cody, J. A. Thompson, T. H. Harris, C. Overall, and J. Kipnis. Neuronal integrity, not activity, drives synaptic material clearance by microglia after CNS injury. J Exp Med. 215 (7): 1789, 2018.

O’Brien, C. A., C. Overall, C. Konradt, A. O’Hara Hall, N. W. Hayes, S. Wagage, B. John, D. A. Christian, C. A. Hunter, and T. H. Harris. CD11c-expressing cells affect Treg behavior in the meninges during CNS infection. J Immunol. 198 (10): 4054-4061, 2017.

Louveau, A., T. H. Harris, and J. Kipnis. Revisiting the mechanisms of CNS immune privilege. Trends Immunol. 36 (10): 569-577, 2015.

Louveau, A., I. Smirnov, T. J. Keyes, J. D. Eccles, S. J. Rouhani, J. D. Peske, N. C. Derecki, D. Castle, J. W. Mandell, K. S. Lee, T. H. Harris, and J. Kipnis. Structural and functional features of central nervous system lymphatics. Nature. 523: 337-341, 2015.

Landrith, T. A., T. H. Harris, and E. H. Wilson. Characteristics and critical function of CD8⁺ T cells in the Toxoplasma-infected brain. Semin Immunopathol. 37 (3): 261-270, 2015.

Cronk, J. C., N. C. Derecki, E. Ji, Y. Xu, A. Lampano, I. Smirnov, W. Baker, G. T. Norris, N. Coddington, Y. Wolf, A. L. Klibanov, T. H. Harris, S. Jung, V. Litvak, and J. Kipnis. Mecp2: an unexpected regulator of macrophage gene expression and function. Immunity. 42 (4): 679-691, 2015.

Banigan, E. J., T. H. Harris, D. A. Christian. C. A. Hunter, and A. J. Liu. Heterogeneous CD8⁺ T cell migration in the lymph node in the absence of inflammation revealed by quantitative migration analysis. PLoS Comput. Biol. 11 (2): e1004058, 2015.

Butler, N. S., T. H. Harris, and I. Blader. Regulation of immunopathogenesis during Plasmodium and Toxoplasma infections: more parallels than distinctions? Trends Parasitol. 29 (12): 593-602, 2013.

Harris, T. H., E. Banigan, D. A. Christian, C. Konradt, E. D. Tait Wojno, K. Norose, E. H. Wilson, B. John, W. Weninger, A. D. Luster, A. Liu, and C. A. Hunter. Generalized Lévy walks and the role of chemokines in migration of effector CD8⁺ T cells. Nature. 486: 545–548, 2012.