Ukpong Eyo, Ph.D.

Ukpong Eyo

Eyo Lab Webpage

Primary Appointment

Neuroscience

Education

  • BS, Biology: Pre-Professional Zoology, Northwest Missouri State
  • PhD, Biology: Neuroscience, University of Iowa
  • Postdoc, Microglia-Neuron Interactions, Rutgers University, NJ
  • Postdoc, Microglia-Neuron Interactions, Mayo Clinic, Rochester, MN

Contact Information

409 Lane Road
Charlottesville, VA 22908
Email: ube9q@virginia.edu

Research Interests

Neuroscience/Neuroimmunology

Research Description

Microglia in neurodevelopment and neurodevelopment disorders

Selected Publications

Eyo UB, Mo M, Yi MH, Murugan M, Liu J, Yarlagadda R, Margolis DJ, Xu P, Wu LJ, P2Y12R-Dependent Translocation Mechanisms Gate the Changing Microglial Landscape., 2018; Cell reports. 23(4) 959-966. PMID: 29694903 | PMCID: PMC5965271

Eyo UB, Bispo A, Liu J, Sabu S, Wu R, DiBona VL, Zheng J, Murugan M, Zhang H, Tang Y, Wu LJ, The GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions., 2018; Scientific reports. 8(1) 828. PMID: 29339791 | PMCID: PMC5770428

Bosco DB, Zheng J, Xu Z, Peng J, Eyo UB, Tang K, Yan C, Huang J, Feng L, Wu G, Richardson JR, Wang H, Wu LJ, RNAseq analysis of hippocampal microglia after kainic acid-induced seizures., 2018; Molecular brain. 11(1) 34. PMID: 29925434 | PMCID: PMC6011524

Zhao X, Eyo UB, Murugan M, Wu LJ, Microglial interactions with the neurovascular system in physiology and pathology., 2018; Developmental neurobiology. 78(6) 604-617. PMID: 29318762 | PMCID: PMC5980686

Tian DS, Peng J, Murugan M, Feng LJ, Liu JL, Eyo UB, Zhou LJ, Mogilevsky R, Wang W, Wu LJ, Chemokine CCL2-CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus., 2017; The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(33) 7878-7892. PMID: 28716963 | PMCID: PMC5559763

Eyo UB, Peng J, Murugan M, Mo M, Lalani A, Xie P, Xu P, Margolis DJ, Wu LJ, Regulation of Physical Microglia-Neuron Interactions by Fractalkine Signaling after Status Epilepticus., 2017; eNeuro. 3(6) . PMID: 28101527 | PMCID: PMC5237828

Eyo UB, Murugan M, Wu LJ, Microglia-Neuron Communication in Epilepsy., 2016; Glia. 65(1) 5-18. PMID: 27189853 | PMCID: PMC5116010

Swiatkowski P, Murugan M, Eyo UB, Wang Y, Rangaraju S, Oh SB, Wu LJ, Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury., 2016; Neuroscience. 318() 22-33. PMID: 26791526 | PMCID: PMC4753827

Gu N, Peng J, Murugan M, Wang X, Eyo UB, Sun D, Ren Y, DiCicco-Bloom E, Young W, Dong H, Wu LJ, Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury., 2016; Cell reports. 16(3) 605-14. PMID: 27373153 | PMCID: PMC4956495

Eyo UB, Gu N, De S, Dong H, Richardson JR, Wu LJ, Modulation of microglial process convergence toward neuronal dendrites by extracellular calcium., 2015; The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(6) 2417-22. PMID: 25673836 | PMCID: PMC4323526

Eyo UB, Miner SA, Weiner JA, Dailey ME, Developmental changes in microglial mobilization are independent of apoptosis in the neonatal mouse hippocampus., 2015; Brain, behavior, and immunity. 55() 49-59. PMID: 26576723 | PMCID: PMC4864211

Liu J, Tian D, Murugan M, Eyo UB, Dreyfus CF, Wang W, Wu LJ, Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage., 2015; Journal of neurochemistry. 135(2) 347-56. PMID: 26173779 | PMCID: PMC4721248

Gu N, Eyo UB, Murugan M, Peng J, Matta S, Dong H, Wu LJ, Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain., 2015; Brain, behavior, and immunity. 55() 82-92. PMID: 26576724 | PMCID: PMC4864135

Eyo UB, Peng J, Swiatkowski P, Mukherjee A, Bispo A, Wu LJ, Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus., 2014; The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(32) 10528-40. PMID: 25100587 | PMCID: PMC4200107

Dailey ME, Eyo U, Fuller L, Hass J, Kurpius D, Imaging microglia in brain slices and slice cultures., 2013; Cold Spring Harbor protocols. 2013(12) 1142-8. PMID: 24298036

Eyo UB, Wu LJ, Bidirectional microglia-neuron communication in the healthy brain., 2013; Neural plasticity. 2013() 456857. PMID: 24078884 | PMCID: PMC3775394

Eyo UB, Miner SA, Ahlers KE, Wu LJ, Dailey ME, P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation., 2013; Neuropharmacology. 73() 311-9. PMID: 23770338 | PMCID: PMC3786777

Eyo UB, Dailey ME, Microglia: key elements in neural development, plasticity, and pathology., 2013; Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 8(3) 494-509. PMID: 23354784 | PMCID: PMC3657325

Eyo U, Dailey ME, Effects of oxygen-glucose deprivation on microglial mobility and viability in developing mouse hippocampal tissues., 2012; Glia. 60(11) 1747-60. PMID: 22847985 | PMCID: PMC3786781