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Neuroscience

Representative Publications

  1.  Lulu Jiang, Rebecca Roberts, Melissa Wong, Lushuang Zhang, Chelsea Joy Webber, Alper Kilci, Matthew Jenkins, Sherif Rashad, Jingjing Sun, Peter Dedon, Sarah Anne Daley, Weiming Xia, Alejandro Rondon Ortiz, Luke Dorrian, Takaomi C. Sado, Takashi Saido, Benjamin Wolozin. Accumulation of m6A exhibits stronger correlation with MAPT than beta-amyloid pathology in an APPNL-G-F /MAPTP301S mouse model of Alzheimer’s disease. bioRxiv 2023.03.28.534515; doi: https://doi.org/10.1101/2023.03.28.534515 (under review by Molecular Neurodegeneration)
  2. Jiang L#, Chakraborty P#, Zhang L, Wong M, Hill SE, Webber CJ, Libera J, Blair LJ, Wolozin B, Zweckstetter M. Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress. Science Advances, 2023 Feb 3;9(5):eadd9789. doi: 10.1126/sciadv.add9789. Epub 2023 Feb 1. PMID: 36724228. (#Co- first authors)

This paper was reported and commented by Alzforum News: https://www.alzforum.org/news/research-news/chaperone-fkbp12-shields-tau-aggregation

  1. Rickner HD#, Jiang L#, Hong R, O’Neill NK, Mojica CA, Snyder BJ, Zhang L, Shaw D, Medalla M, Wolozin B, Cheng CS. Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model. Nat Commun. 2022 Oct 21;13(1):6275. doi: 10.1038/s41467-022-34005-1. PMID: 36271092; PMCID: PMC9587045. (#Co- first authors)
  2. Jiang L, Lin W, Zhang C, Ash PEA, Verma M, Kwan J, van Vliet E, Yang Z, Cruz AL, Boudeau S, Maziuk BF, Lei S, Song J, Alvarez VE, Hovde S, Abisambra JF, Kuo MH, Kanaan N, Murray ME, Crary JF, Zhao J, Cheng JX, Petrucelli L, Li H, Emili A, Wolozin B. Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy. Mol Cell. 2021 Aug 20:S1097-2765(21)00622-5. doi: 10.1016/j.molcel.2021.07.038. PMID: 34453888.

Research Highlight by Nature Reviews Molecular Cell Biology. Corresponding Commentary article by Editor-in-chief Dr. Baumann, K.: Tau oligomers are linked to m6A-RNA. Nat Rev Mol Cell Biol. 2021 Oct;22(10):650. doi: 10.1038/s41580-021-00419-w. PMID: 34480148.

This paper was reported and commented by Alzforum News: https://www.alzforum.org/news/research-news/methylated-rna-new-player-tau-toxicity

  1. Jiang L, Wolozin B. Oligomeric tau disrupts nuclear envelope via binding to lamin proteins and lamin B receptor. Alzheimer’s & Dementia. 2021 Dec;17:e054521.
  2. Jiang L, Wolozin B. Regulation of ribosomal function by oligomeric tau: Dysregulation of protein synthesis in neurodegeneration. Alzheimer’s & Dementia, 2020/12, 16, e039190
  3. Jiang L, Zhao J, Cheng JX, Wolozin B. Tau Oligomers and Fibrils Exhibit Differential Patterns of Seeding and Association With RNA Binding Proteins. Front Neurol. 2020 Sep 30;11:579434. doi: 10.3389/fneur.2020.579434. PMID: 33101187; PMCID: PMC7554625.
  4. Jiang L, Ash PEA, Maziuk BF, Ballance HI, Boudeau S, Abdullatif AA, Orlando M, Petrucelli L, Ikezu T, Wolozin B. TIA1 regulates the generation and response to toxic tau oligomers. Acta Neuropathol. 2019 Feb;137(2):259-277. doi: 10.1007/s00401-018-1937-5. Epub 2018 Nov 21. PMID: 30465259; PMCID: PMC6377165.
  5. Song S#, Jiang L#, Oyarzabal EA, Wilson B, Li Z, Shih YI, Wang Q, Hong JS. Loss of Brain Norepinephrine Elicits Neuroinflammation-Mediated Oxidative Injury and Selective Caudo-Rostral Neurodegeneration. Mol Neurobiol. 2019 Apr;56(4):2653-2669. doi: 10.1007/s12035-018-1235-1. Epub 2018 Jul 27. PMID: 30051353; PMCID: PMC6348128. (# Co- first authors).
  6. Jiang L, Wu X, Wang S, Chen SH, Zhou H, Wilson B, Jin CY, Lu RB, Xie K, Wang Q, Hong JS. Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase. J Neuroinflammation. 2016 May 16; 13(1):110. doi: 10.1186/s12974-016-0573-z. PMID: 27184631
  7. Jiang L, Chen SH, Chu CH, Wang SJ, Oyarzabal E, Wilson B, Sanders V, Xie K, Wang Q, Hong JS. A novel role of microglial NADPH oxidase in mediating extra-synaptic function of norepinephrine in regulating brain immune homeostasis. Glia. 2015 Jun;63(6):1057-72. Epub 2015 Mar 4. PMID: 25740080; PMCID: PMC4405498.
  8. Ash PEA, Lei S, Shattuck J, Boudeau S, Carlomagno Y, Medalla M, Mashimo BL, Socorro G, Al-Mohanna LFA, Jiang L, Öztürk MM, Knobel M, Ivanov P, Petrucelli L, Wegmann S, Kanaan NM, Wolozin B. TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau. Proc Natl Acad Sci USA. 2021 Mar 2;118(9):e2014188118. doi: 10.1073/pnas.2014188118. PMID: 33619090; PMCID: PMC7936275.
  9. Wang Q, Song S, Jiang L, Hong JS. Interplay among norepinephrine, NOX2, and neuroinflammation: key players in Parkinson’s disease and prime targets for therapies. Ageing Neur Dis 2021;1:6. http://dx.doi.org/10.20517/and.2021.06
  10. Apicco DJ, Zhang C, Maziuk B, Jiang L, Ballance HI, Boudeau S, Ung C, Li H, Wolozin B. Dysregulation of RNA Splicing in Tauopathies. Cell Rep. 2019 Dec 24;29(13):4377-4388.e4. doi: 10.1016/j.celrep.2019.11.093.
  11. Song S, Wang Q, Jiang L, Oyarzabal E, Riddick NV, Wilson B, Moy SS, Shih YI, Hong JS. Noradrenergic dysfunction accelerates LPS-elicited inflammation-related ascending sequential neurodegeneration and deficits in non-motor/motor functions. Brain Behav Immun. 2019 Oct;81:374-387. doi: 10.1016/j.bbi.2019.06.034. Epub 2019 Jun 24.
  12. Maziuk BF, Apicco DJ, Cruz AL, Jiang L, Ash PEA, da Rocha EL, Zhang C, Yu WH, Leszyk J, Abisambra JF, Li H, Wolozin B. RNA binding proteins co-localize with small tau inclusions in tauopathy. Acta Neuropathol Commun. 2018 Aug 1;6(1):71. doi: 10.1186/s40478-018-0574-5.
  13. Wang Q, Chu CH, Oyarzabal E, Jiang L, Chen SH, Wilson B, Qian L, Hong JS. 2014. Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases. Glia.2014 Dec; 62(12):2034-43. doi: 10.1002/glia.22724.
  14. Wang Q, Chu CH, Qian L, Chen SH, Wilson B, Oyarzabal E, Jiang L, Ali S, Robinson B, Kim HC, Hong JS. Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase. J Neurosci. 2014 Sep 10; 34(37):12490-503. doi: 10.1523/JNEUROSCI.2238-14.2014.

Complete List of Published Work and citations can be found on Lulu Jiang google scholar page:

https://scholar.google.com/citations?user=bL7Uk2sAAAAJ&hl=en&oi=ao

 

 

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