Cell Stem Cell Cover pageTh17 Cells in Parkinson’s Disease: The Bane of the Midbrain.

Cell Stem Cell
Ashley C. Bolte, John R. Lukens.



Picture of open field dataCritical Roles for Microbiota-Mediated Regulation of the Immune System in a Prenatal Immune Activation Model of Autism.

Journal of Immunology
Catherine R. Lammert, Elizabeth L. Frost, Ashley C. Bolte, Matt J. Paysour, Mariah E. Shaw, Calli E. Bellinger, Thaddeus K. Weigel, Eli R. Zunder and John R. Lukens.


NLR inflammation imageNLR-Dependent Regulation of Inflammation in Multiple Sclerosis.

Frontiers in Immunology
Marjan Gharagozloo, Katsiaryna V. Gris, Tara Mahvelati, Abdelaziz Amrani, John R. Lukens, and Denis Gris.



Image from paperOxidized Low-Density Lipoprotein Immune Complex Priming of the Nlrp3 Inflammasome Involves TLR and FcγR Cooperation and Is Dependent on CARD9.

Journal of Immunology
Jillian P. Rhoads, John R. Lukens, Ashley J. Wilhelm, Jared L. Moore, Yanice Mendez-Fernandez, Thirumala-Devi Kanneganti and Amy S. Major.


Immunity Cover pageTyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.

Prajwal Gurung, Gaofeng Fan, John R. Lukens, Peter Vogel, Nicholas K. Tonks, Thirumala-Devi Kanneganti.



Frontiers in ImmunologyEmerging Roles for the Immune System in Traumatic Brain Injury.

Frontiers in Immunology
Celia A. McKee, John R. Lukens.


Nature Cover Page

The Brain’s Reward Circuitry Regulates Immunity.

Elizabeth L Frost, John R. Lukens.


Neuron Cover Page

Dealing with Danger in the CNS: The Response of the Immune System to Injury.

Sachin P. Gadani, James T. Walsh, John R. Lukens, Jonathan Kipnis.


Immunity Cover Page

The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells.

Lukens JR, Gurung P, Shaw PJ, Barr MJ, Zaki MH, Brown SA, Vogel P, Chi H, Kanneganti TD.


Dietary Modulation - Nature Cover Page

Dietary modulation of the microbiome affects autoinflammatory disease.

Lukens JR, Gurung P, Vogel P, Johnson GR, Carter RA, McGoldrick DJ, Bandi SR, Calabrese CR, Vande Walle L, Lamkanfi M, Kanneganti TD.


RIP1-Driven Autoinflammation -Nature Cover Page

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

Lukens JR, Vogel P, Johnson GR, Kelliher MA, Iwakura Y, Lamkanfi M, Kanneganti TD.


Critical Role for Inflammasome -PNAS Cover Page

Critical role for inflammasome-independent IL-1β production in osteomyelitis.

Proceedings of the National Academy of Sciences USA
Lukens JR, Gross JM, Calabrese C, Iwakura Y, Lamkanfi M, Vogel P, Kanneganti TD.


Inflammasome-Derived IL-1B - The Journal of Immunology Cover Page

Inflammasome-derived IL-1β regulates the production of GM-CSF by CD4(+) T cells and γδ T cells.

The Journal of Immunology
Lukens JR, Barr MJ, Chaplin DD, Chi H, Kanneganti TD.


Beyond Canonical Inflammasomes

Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease.

Seminars in Immunopathology
Lukens JR, Kanneganti TD.


IL-1 family cytokines trigger sterile inflammatory disease

IL-1 family cytokines trigger sterile inflammatory disease.

Frontiers in Immunology
Lukens JR, Gross JM, Kanneganti TD.





Complete PubMed publication list