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Neuroscience

J. Javier Provencio, M.D.

Dr. J. Javier Provencio, MD                                          2015 Provencio UVa

Louise Nerancy Associate Professor in Neurology
Director, Nerancy Neuroscience Intensive Care Unit
Associate Professor, Center for Brain Immunology and Glia, Neuroscience
jp3b@virginia.edu

 

Dr. Provencio’s Lab

 

Education:

B.A., 1989, Swarthmore College

M.D., 1993, Pennsylvania State University College of Medicine

 

Postdoctoral Training:

Intern in internal medicine, 1993 – 1994, Medical University of South Carolina

Resident in neurology, 1994 – 1997, University of Virginia

Postdoctoral fellow in biology, 1996 – 1997, University of Virginia

Resident in internal medicine, 1997 – 1998, University of Virginia

Fellow in medical critical care, 1998 – 1999, University of Virginia

Fellow in neurocrticial care, 1999 – 2000, University of Virginia

 

Research Interests:

PRIMARY

  • Innate inflammatory pathways associated with acute aneurysmal subarachnoid hemorrhage. We explore the role of myeloid cell recruitment into the central nervous system after subarachnoid hemorrhage and to determine which effector molecules in neutrophils and monocytes are responsible for the brain damage associated with delayed cerebral deterioration. Using a novel murine model of mild subarachnoid hemorrhage that allows evaluation of late cognitive effects, we have been able to show that systemic neutrophils play a role in impaired long term potentiation and memory function after SAH. We therefore have recently focused our attention on elucidating changes to the hippocampal memory mechanism after SAH. Our ultimate goal is to develop targets for treatments in patients with SAH exploiting inflammatory mechanisms.

 

SECONDARY

  • Cognitive outcomes associated with acute inflammatory changes in aneurysmal subarachnoid hemorrhage. We have developed a parallel human research program to validate mechanisms uncovered by the murine model. We hope to use this strategy to develop translatable solutions for patients with subarachnoid hemorrhage.
  • Systemic normothermia in intracerebral hemorrhage. Our laboratory has completed a single centered, randomized, single blind trial of forced systemic normothermia in patients with acute spontaneous intracerebral hemorrhage.   Our preliminary result showed that the design is feasible and safe and that there are changes in serum innate inflammatory levels in patients with normothermia compared to controls and that there is a trend toward improved perihematomal relative edema.

 

Confocal Neutrophil#1DC95D7

Publications:

    1. Frontera,JA, Provencio, JJ, Sehba, FA, McIntyre, T, Nowacki, A, Gordon, E, Weimer, JA, Rasmussen, P, Aledort, L, Journal of Thrombosis and Hemostasis 2016 (in press).
    2. Provencio, JJ, Swank, V, Lu, H, Brunet, S,Baltan, S, Khapre, RV, Seerapu, H, Kokiko-Cochran, ON, Lamb, BT,Ransohoff, RM. Neutrophil depletion after subarachnoid hemorrhage improves behavioral memory tasks in an NMDA receptor dependent manner. 2016 Brain Immunology and Behavior. 10.1016/j.bbi.2016.02.007.
    3. Provencio, JJ, Badjatia, N. Monitoring inflammation (including fever) in acute brain injury: International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care. Neurocrit Care. 2014. DOI: 10.1007/s12028-014-0038-0. PMID: 25315974.
    4. Gomes, JA, Cotleur, A, Selim, M, Provencio, JJ. Brain iron metabolism and early brain injury following aneurysmal subarachnoid hemorrhage. Neurocritical Care 2014 DOI 10.1007/s12028-014-9977-8. PMID: 24710655.
    5. Alexander SA, Provencio, JJ. J Neurosurg. 2014;120(2):384-5. PMID: 24645183
    6. Kantor, E, Bayir, H, Ren, D, Provencio, JJ, Crago, E, Horowitz, MB, Ferrell, RE, Conley, YP, Alexander, SA. Haptoglobin Genotype and Functional Outcome after Aneurysmal Subarachnoid Hemorrhage. (2011) Neurocritical care. (in review)
    7. Smithason, S, Moore, SK, Provencio, JJ*. Low-dose lipopolysaccharide injection prior to subarachnoid hemorrhage modulates delayed deterioration associated with vasospasm in subarachnoid hemorrhage. (2011) Acta Neurochirurgica Supplementum, Vol. 115, DOI 10.1007/978-3-7091-1192-5_45.
    8. Provencio, JJ*. Inflammation in subarachnoid hemorrhage and delayed deterioration associated with vasospasm: A review. Acta Neurochirurgica Supplementum, Vol. 115, 2011. DOI 10.1007/978-3-7091-1192-5_42.
    9. Smithason, S, Moore, SK, Provencio, JJ*. Systemic administration LPS worsens delayed cerebral vasospasm after subarachnoid hemorrhage through a myeloid cell dependent mechanism. (2011) Neurocritical Care 2012, Volume 16, Number 2, Pages 327-334. DOI: 1007/s12028-011-9651-3.
    10. Spiotta AM, Provencio JJ, Rasmussen PA, Manno E. Brain monitoring following subarachnoid hemorrhage: Lessons learned. Neurosurgery 69: 755-766. 2010. PMID 21508881.
    11. JJ*, Altay, T, Smithason, S, Moore, SK, Ransohoff, RM. Depletion of Ly6G/C+ cells ameliorates delayed cerebral vasospasm in subarachnoid hemorrhage. Journal of Neuroimmunology. 2010 (In press). DOI: 10.1016/j.jneuoim.2010.10.016. PMID: 4118297
    12. Provencio JJ*, Fu X., Siu A., Rasmussen P.A., Hazen S.L., Ransohoff R.M. CSF Neutrophils Are Implicated in the Development of Vasospasm in Subarachnoid Hemorrhage. Neurocrit Care 2010. 12(2): 244-251. (DOI: 10.1007/s12028-009-9308-7). PubMed PMID: 19967568; PubMed Central PMCID: PMC2844469.
    13. Altay, T, Smithason, S, Volokh, N, Rasmussen, P, Ransohoff, RM, Provencio, JJ*. A novel method for subarachnoid hemorrhage to induce vasospasm in mice. Journal of Neuroscience Methods 183 (2009) 136–140. PubMed PMID: 19576247; PubMed Central PMCID: PMC2769994.
    14. Moskowitz, S.I., Ahrens, C., Provencio, JJ, Chow, M. and P.A. Rasmussen Pre-hemorrhage statin use and the risk of vasospasm following aneurysmal subarachnoid hemorrhage (2009). Surgical Neurology 71(3): 311-317. PubMed PMID: 18423529; PubMed Central PMCID: PMC2971680.
    15. Mashaly, HA, Provencio, JJ*. Inflammation as a link between brain injury and heart damage: The model of subarachnoid hemorrhage (2008). Cleveland Clinic Journal of Medicine. 75 (Supplement 2): S26-S30.
    16. Provencio JJ. Subarachnoid hemorrhage: a model for heart-brain interactions. Cleveland Clinic Journal of Medicine. 74 Suppl 1:S86-90, 2007.
    17. Bell, RD, Brock, D, Provencio, JJ, Flanders, A, Benitez, R, Rosenwasser, R, Strause, J, Frazer, G, Powers, BL, Hesson, D, Barnitz, J, Ohsterholm, JL.   Ventriculo-Lumbar Perfusion in Acute Ischemic Stroke. Neurocritical Care 2006, 5: 21-29.
    18. Provencio, JJ*, Kivisäkk, P, Tucky, BH, Luciano, MG, Ransohoff, RM. Comparison of ventricular and lumbar cerebrospinal fluid T cells in non-inflammatory neurological disorder (NIND) patients. Journal of Neuroimmunology. 163 (1-2): 179-184. 2005.

More at PubMed

Contact:

Dr. Jose Javier Provencio
jp3b@virginia.edu
University of Virginia
Department of Neurology
Center for Brain Immunology and Glia (BIG)
P.O. Box 800394
409 Lane Road, MR-4, Room 5111
Charlottesville, VA 22908
Office: (434)-297-7608
Lab: (434)-297-7625

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