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Translational Pipeline

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The UVA Comprehensive Cancer Center Translational Pipeline is the mechanism by which ideas and discoveries generated by UVACCC members are developed and translated into products that can positively impact the lives of patients. The Translational Pipeline has two interconnected tracks: Clinical Trial and Commercialization.

To contact ORD regarding the Translational Pipeline, please click the button at right or email jck3xb@uvahealth.org.

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The “Full Circle” of Translational Research

A circular flow diagram titled “The ‘Full Circle’ of Translational Research” represents the process of translational research in seven steps. Step one: Basic understanding and discovery; Step two: Therapeutic or diagnostic target identification. Step three: Synthesis of drug or development of prototype device or process. Step four: Pre-clinical testing. Step five: Human testing, clinical trials. Utilization research, product launch. Clinical observation, post-induction monitoring.

Clinical Trial Track

Projects on the Clinical Trial Track can emerge from the Commercialization Track or from ideas and data that support repurposing and/or combining approved treatments for new indications. Members interested in developing an investigator-initiated clinical trial (IIT) are encouraged to get feedback from the Cancer Therapeutics Program (CRX) and appropriate Translational Research Teams (TRTs), if they exist. The Cancer Center has a robust clinical trials infrastructure to enable all aspects of a clinical trial beginning with writing the protocol and including all required aspects to the end of the study. Information about clinical trial resources can be found through the following links:

Commercialization Track

Projects in the Commercialization Track are those associated with intellectual property and enter the Translational Pipeline either at the time of disclosure or when an investigator indicates an interest in pursuing patent protection for their project. The Cancer Center created the Accelerating Innovation Fund (AIF) to support innovative, entrepreneurial cancer-relevant biomedical research projects with commercialization potential. For more information, visit the Cancer Center’s AIF web page. Additional resources to support commercialization activities can be found through the following links: