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Biomedical Sciences Graduate Program

Biochemistry

About

Research in Biochemistry at UVA seeks to identify biologically relevant molecules and study their synthesis, degradation, and role in biological processes.Since molecules interact in complex ways in living organisms, modern biochemical research is a collaborative, interdisciplinary effort. Approaches that are used include molecular biology, genetics, epigenetics, bioinformatics, computational biology, structural biology, and many others.  More than 60 faculty from these areas form our robust and dedicated group of mentors in biochemistry.

Research in biochemistry at UVA ranges from computational analysis to clinical applications for cancer and cardiovascular disease. Biochemical studies of interacting proteins, DNA, and sub-cellular structures in normal and disease states provide a wide array of research opportunities.  This research, coupled with a broad collection of graduate courses, furnish our students with the skills and background necessary for successful careers in biomedical research and education.

Faculty

  • Abbas, Tarek A.

    The Ubiquitin System and Human Cancer

  • Abounader, Roger

    Basic and translational brain tumor research

  • Ai, Huiwang

    Molecular Biosensors; Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics

  • Bao, Huan

    Biophysics of membrane pore formation; research and therapeutic applications of lipid nanoparticles.

  • Bielinsky, Anja Katrin

    Genome instability syndromes in cancer and immune deficiencies

  • Bourne, Philip E

    Data Science

  • Chalfant, Charles Edward

    Hematology and Oncology, Cell Biology, Lipid Signaling, Cancer Cell Signaling, and RNA Biology

  • Columbus, Linda

    Biophysical Chemistry: Membrane protein structure, function, and dynamics

  • Derewenda, Zygmunt S.

    Structure-function relationships in proteins

  • Ebrahim, Seham

    Cytoskeletal architecture, dynamics and roles in cellular physiology and disease; High-resolution live cell and tissue imaging

  • Egelman, Edward H.

    Structure and Function of Macromolecular Complexes Using Electron Microscopy

  • Fallahi-Sichani, Mohammad

    Cancer systems biology, Single-cell quantitative biology, Computational modeling

  • Felder, Robin A.

    Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.

  • Flowers, Sarah

    Impact of APOE and lipid metabolism on cell function in Alzheimer's disease.

  • Fox, Jay W.

    Basement Membrane Structure and Metalloproteinases

  • Garcia-Blanco, Mariano A.

    RNA-protein interactions in antiviral immunity and autoimmune diseases.

  • Gaultier, Alban

    Exploring new therapeutics avenues to treat Multiple Sclerosis.

  • Gioeli, Daniel

    Signal transduction in cancer cells

  • Goldfarb, Adam N.

    Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis

  • Harris, Thurl E

    Molecular mechanisms controlling insulin signaling and fat synthesis.

  • Hendrickson, Eric A

    Hematology & Oncology

  • Jiang, Hao

    Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)

  • Jomaa, Ahmad

    Localisation of nascent proteins to sub-cellular compartments

  • Kendall, Melissa M.

    Bacterial cell signaling, host-pathogen interactions, intestinal pathogens

  • Levental, Ilya

    Composition, Biophysics and Physiology of Cellular Membranes

  • Liu, Wenpeng

    Genetic and Epigenetic stability in human cancer

  • Lu, Xiaowei

    Wnt/PCP signaling in inner ear development Mouse models for human deafness Wnt/PCP signaling in neural tube closure

  • Lynch, Kevin R.

    Chemical biology of sphingosine 1-phosphate

  • Manichaikul, Ani W.

    Statistical Genetics, Genetic Epidemiology, Biostatistics, Network analysis

  • Mayo, Marty W.

    Transcriptional Regulation by NFKB

  • Miller, Clint L.

    Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology

  • Mohi, Golam

    Cell signaling, stem cell biology, molecular and epigenetic mechanisms of blood and breast cancers

  • Naegle, Kristen

    Regulation and function of tyrosine phosphorylation in complex networks

  • O’Rourke, Eyleen Jorgelina

    Obesity and Aging

  • Papin, Jason A.

    Systems biology, infectious disease, cancer, toxicology, metabolic engineering

  • Park, Kwon-Sik

    Mechanisms of tissue/organ homeostasis and tumorigeensis

  • Paschal, Bryce M.

    Nuclear Transport, Signaling, and Cancer

  • Pemberton, Lucy F.

    Director of Graduate Studies for Microbiology, Immunology and Cancer Biology

  • Ramakrishnan, Girija

    Microbial Pathogenesis

  • Rekosh, David M.

    Human Immunodeficiency Virus Gene Expression; Human Endogenous Viruses; SARS-CoV-2 Protein Trafficking; Post-transcriptional Gene Regulation

  • Schulman, Ira G.

    Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery

  • Shin, Jung-Bum

    Auditory Neurobiology

  • Smith, Jeffrey S.

    Transcriptional Silencing and Aging in Yeast

  • Spencer, Brady

    Gram-positive pathogenesis; type VII secretion; impact of secreted effectors on host-pathogen interactions and immune responses

  • Spiliotis, Elias T

    Spatial Cell Biology. Neuronal Morphogenesis and Disease. Cancer Migration and Invasion.

  • Stukenberg, P. Todd

    Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors

  • Tak, Uday

    Prokaryotic immune systems, bacteriophage virology, programmed cell death, pore-forming proteins, evolution of immunity, protein engineering

  • Tamm, Lukas K.

    Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions

  • Tang, Shangming

    Complex Genome Rearrangements

  • Trinh, Bon Q

    Understanding Protein and RNA regulations of gene expression via chromatin structure in myeloid cell development and diseases

  • Tsai, Ming-Feng

    Membrane-transport physiology and biophysics

  • Tsihlis, Nick

    Vascular Biology, Nanotechnology, Biomaterials, Drug Delivery

  • Vande Pol, Scott B.

    How Viruses, Particularly Papillomaviruses, Can Cause Cancer

  • Walsh, Kenneth

    Clonal hematopoiesis: A new mechanism of cardiovascular disease

  • Wang, Yuh-Hwa

    Genome instability in cancer and repeat expansion diseases

  • Whitlock, Jarred M

    The formation, function, coordination, and pathology of multinucleated cell types that make up the placenta and musculoskeletal system.

  • Wotton, David

    Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling

  • Xie, Jinghang

    Molecular Imaging; Cancer Immunology; Vaccines; Antibiotic Resistance.

  • Zeitlin, Scott O.

    Mechanisms of Huntington's Disease Pathogenesis

  • Zhang, Tian

    Integrating high-throughput proteomic, chemical, genetic and computational tools for target identification and drug discovery in cancer biology

  • Zimmer, Jochen

    Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.

  • Zimring, James C

    Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease

  • Zunder, Eli

    Single Cell Analysis

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