Joshua Li, MD, PhD
Dr. Joshua Li is the Mary Muilenburg Stamp Professor of Orthopaedic Research and Fellowship Director for the University of Virginia’s Surgery of the Spine Fellowship. Dr. Li was born and grew up in China. He attended Xi’an Medical University for both his M.D. and Ph.D. He came to the United States in 1999.
Dr. Li holds dual appointments as Associate Professor in the departments of Orthopaedic Surgery and Biomedical Engineering at UVA. He completed an Orthopaedic Surgery residency at UVA, and a comprehensive Spine Surgery fellowship at the world-renowned Columbia Spine Hospital with Drs. Lenke, Riew and Lehman. Dr. Li has advanced expertise in a wide range of spinal procedures from microscope-assisted cervical artificial disc replacement, to single position OLIF, to the most complex spinal reconstruction for scoliosis. His clinical interests include degenerative disorders of the cervical, thoracic, and lumbar spine (herniated disc, spinal stenosis, etc.), spinal deformities (scoliosis, kyphosis, flatback syndrome, etc.), spinal tumors, metastatic spine disease, spine trauma, minimally invasive spine surgery, robotic assisted spine surgery, and motion-sparing technology (artificial disc replacement).
Dr. Li has developed a renowned laboratory that focuses on intervertebral disc degeneration pathology and treatment with stem cells, nanotechnology, and gene therapy. He has been the recipient of over 30 grants as the Principle Investigator, including five NIH (National Institute of Health R03, R21s, and R01) grants. He serves as a committee member for the Orthopaedic Research Society (ORS), and the North American Spine Society (NASS). He has been on various grant review panels including those for the NIH, NASA, MTF, and AO-International.
Beyond Orthopaedics
Dr. Li is married to Dr. Li Jin. He likes traveling with his wife and playing badminton. He has also led an exercise group practicing Falun Dafa in Charlottesville for a decade.
Contact
UVA Orthopaedic Center
Spine Care Suite 2304
2280 Ivy Road
Charlottesville, VA 22903
Dept. Orthopaedic Surgery
University of Virginia
PO Box 800159
Charlottesville, VA 22908
434.243.3633
434.982.4832
434.243.1539
Appointments
Mary Muilenburg Stamp Professor of Orthopaedic Research, Department of Orthopaedics Spine Division, University of Virginia
Associate Professor, Department of Biomedical Engineering, University of Virginia
Specialty and Subspecialty
Specialty: Orthopaedic Surgery
Subspecialty: Spine Surgery
Special Expertise
Cervical artificial disc replacement
Robotic-assisted spine surgery
Mini-invasive spine surgery
Spinal reconstruction for scoliosis
Research
Intervertebral disc degeneration pathology and treatment with stem cells, nanotechnology, and gene therapy
Current IRB Studies
Relaxin in Degen Spondy
ULBD vs Fusion Study
Coin Test Gait Analysis with AI
Intraoperative Blood/Tissue Analysis
Comparison of L4-S1 ALIF and TLIF on Restoring Lordosis Distribution Index and Proximal Failure Rates
Cervical Myelopathy Coin Test
Psoas Muscle Volume s/p XLIF/OLIF
Lumbar Lordosis s/p TLIF w/wo PCO
Effect of Screw Size on Pseudoarthrosis in ACDF
Disc Herniation in Pts Receiving Immunomodulating Therapy
ACDF – Cage Subsidence in Sarcopenia
ENT Eval Prior to Revision ACDF
TLIF Cage Expandable vs Static
Education
Primary Education: Xi’an Medical University
Residency:Orthopaedic Surgery, University of Virginia
Orthopaedic Research Fellowship, University of Virginia
Fellowships: Spine Surgery, Columbia University Spine Hospital
– Lawrence Lenke (pediatric and adult spinal deformity)
– Daniel Riew (cervical spine surgery)
– Ron Lehman (robotic assisted and minimally invasive surgery)
Certification and Licensure
Certification: American Board of Orthopaedic Surgery
Licensed to practice in Virginia
Recent Publications
Biswas R, Manley B, Xiao L, Lee K, Jin L, Li X, Zhang J. “ROS Scavenging Capacity of Functional Fullerenes in Solution and in Macrophage Cells.”
ACS Applied Nano Materials. 2024;7(15):18036-18044.
Deng B, Li X, Xie P, Luo X, Yan X. “Intravenous Versus Topical Tranexamic Acid in Spinal Surgery: A Systematic Review and Meta-Analysis.”
J Orthop Surg Res. 2024 Aug 27;19(1):512. doi: 11/1186/s13018-024-04989-1.
PMID: 39192283.
Zhang Z, Chi J, Manley B, Oh E, Yang H, Wang J, Li X. “Inflammatory Bowel Disease as a Risk Factor for Complications and Revisions Following Lumbar Discectomy.”
Global Spine J. 2024 Jul 28:21925682241270069. doi: 10.1177/21925682241270069. Epub ahead of print.
PMID: 39069374.
Chi, J, Raso J, Tadepalli V, Labaran L, Oh E, Wang J, Shen FH, Li X. “Outcomes Following Anterior Cervical Discectomy and Fusion in Patients With Ehlers-Danlos Syndrome.”
Global Spine J. 2024 Jul;14(6):1699-1705. doi: 10.1177.21925682231151924. Epub 2023 Jan 16.
PMID: 36645101.
Chi J, Zhang Y, Fontaine A, Zhang Z, Wang J, Labaran L, Li X. “Pedicle Subtraction Osteotomy Versus Multilevel Anterior Lumbar Interbody Fusion and Lateral Lumbar Interbody Fusion in the Treatment of Adult Spinal Deformity: Trends, Outcomes, and Cost.”
Clin Spine Surg. 2024 Jun 1;37(5):E192-E200. doi: 10.1097/BSD.0000000000001566. Epub 2023 Dec 28.
PMID: 38158597.
Mitchell BA, Chi JA, Driskill EK, Labaran LA, Wang JF, Shen FH, Li XJ. “A Matched-Cohort Analysis of Outcomes in Patients with Hereditary Hemochromatosis After Anterior Cervical Discectomy and Fusion.”
World Neurosurg. 2024 Apr;184:e25-e31. doi: 10.1016/j.wneu.2023.11.050. Epub 2023 Nov 17.
PMID: 37979684.
Jin L, Xiao L, Manley BJ, Oh EG, Huang W, Zhang Y, Chi J, Shi W, Kerrigan JR, Sung SJ, Kuan CY, Li X. “CCR2 Monocytes as Therapeutic Targets for Acute Disc Herniation and Radiculopathy in Mouse Models.”
Osteoarthritis Cartilage. 2024 Jan;32(1):52-65. doi: 10.1016/j.joca.2023.08.014. Epub 2023 Oct 5.
PMID: 37802464.
Xie W, Xing Y, Xiao L, Zhang P, Oh R, Zhang Y, Yu X, He Y, Oh EG, Cao R, Ramasubramanian MK, Wang Y, Jin L, Oberhozler J, Li X. “Intervertebral Disc-on-a-ChipMF: A New Model for Mouse Disc Culture via Integrating Mechanical Loading and Dynamic Medial Flow.”
Adv Mater Technol. 2023 Nov 10;8(21):2300606. doi: 10.1002/admt.202300606. Epub 2023 Aug 27.
PMID: 39130370.
Naik BI, Durieux ME, Dillingham R, Waldman AL, Holstege M, Arbab Z, Tsang S, Cui Q, Li X, Singla A, Yen CP, Dunn LK. “Mobile Health Supported Multi-Domain Recovery Trajectories After Major Arthroplasty or Spine Surgery: A Pilot Feasibility and Usability Study.”
BMC Musculoskelet Disord. 2023 Oct 6;24(1):794. doi: 10.1186/s12891-023-06928-3.
PMID: 37803365.
Chi J, Yang H, Zhang Y, Raso J, Labaran L, Li X. ”Effect of Celiac Disease on Outcomes After Posterior Lumbar Fusion: A Matched Cohort Study.”
World Neursurg. 2023 Jul;175:e855-e860. doi: 10.1016/j.wneu.2023.04.035. Epub 2023 Apr 17.
PMID: 37075896.
Chi J, RasoJ, Tadepalli V, Labaran L, Oh E, Wang J, Shen FH, Li X. “Outcomes Following Anterior Cervical Discectomy and Fusion in Patients With Ehlers-Danlos Syndrome.”
Global Spine J. 2023 Jan 16:21925682231151924. doi: 10.1177/21925682231151924. Online ahead of print
PMID: 36645101.
Additional Information
To learn more about Dr. Li, his research projects, case studies, or patient feedback, please follow the link below.