Gene Structure and Expression

Gene Structure, blue background with yellow lines/ dyeWithin the past decade, there has been remarkable progress in our understanding of the structure of genes, the mechanism of their expression, and the identification of factors regulating this expression in response to environmental or developmental signals.  An understanding of gene regulation is vital for understanding the control of normal cell proliferation and differentiation, as well as the molecular basis of deregulated cell growth that occurs in many human diseases including cancer. This knowledge is obtained both by direct biochemical analysis of the protein-protein and protein-DNA interactions that are essential for gene regulation and by genetic studies, which can reveal the functional relationships of those cellular factors that control the expression of a gene and thus complement the biochemical approaches. Both bacterial and eukaryotic cell systems(including yeast, plants, invertebrates and vertebrates) are providing both general and specific information about gene expression.

Faculty in this area

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David  T.  Auble,  PhD
Molecular Mechanisms of Transcriptional Regulation

Ann  L.  Beyer,  PhD
Ribosomal RNA transcription & processing

Daniel  J.  Burke,  PhD
Regulation of mitosis

Anindya  Dutta,  MD/PhD
Genomic Instability in Cancer Cells; Noncoding RNAs in differentiation and cancer

Daniel  A.  Engel,  PhD
Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Influenza, Dengue and Ebola.

Patrick  A.  Grant,  PhD
Transcription; Chromatin Modifications, Neurodegenerative Disease, Cancer

Joyce  L.  Hamlin,  PhD
Control of Mammalian Chromosomal DNA Replication, and DNA Damage, Repair and Genetic Instability in Cancer

Mani  S.  Mahadevan,  MD
Molecular Mechanisms of Myotonic Muscular Dystrophy

Marty  W.  Mayo,  PhD
Transcriptional Regulation by NFKB

William  R.  Pearson,  PhD
Protein Evolution; Computational Biology

Jeffrey  S.  Smith,  PhD
Transcriptional Silencing and Aging in Yeast

M.  Mitchell  Smith,  PhD
Functional Genomics of Histones, Chromatin, and Protein Acetylation Signaling in Cancer and the Cell Cycle

Michael  P.  Timko,  PhD
Gene regulation during host-parasite interaction

David  Wotton,  PhD
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling