Christopher P. Holstege, MD

Professor of Emergency Medicine and Pediatrics
Chief, Division of Medical Toxicology
Senior Associate Vice President of Student Health & Wellness
Director, Blue Ridge Poison Center
Adjunct Professor of Clinical Pediatrics, Eastern Virginia Medical School

P.O. Box 800699
Charlottesville, VA 22908-0699
Phone: (434) 924-5185
Fax: (434) 971-8657
E-mail: ch2xf@uvahealth.org

Recent Awards

2024 Thomas Jefferson Award for Service, University of Virginia
2021 The Raven Award, University of Virginia Raven’s Society
2021 American Red Cross Christopher E. Lee Humanitarian Hero award
2019 Hoos Building Bridges Award, University of Virginia

Education

Fellowship, Medical Toxicology, Indiana University (1998)
Residency, Emergency Medicine, Butterworth Hospital (1996)
MD, Wayne State University School of Medicine (1993)
BS, Chemistry, Calvin College (1988)

Clinical and Research Interests

Clinical toxicology
Criminal poisoning
Substance use/misuse trends
Student health & wellness

Recent Publications

Cassie, D, et al, Holstege, C, Punch, J, Smith, W, Wyatt, D. “A phase 1, first-in-human, open label, single ascending dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of stabilized isoamyl nitrite nasal spray in healthy adult participants” J. Pharmacol.Exp. Ther. Vol. 392, Issue 6103584 June 2025 DOI: 10.1016/j.jpet.2025.103584
Holstege C, Ross J, Frey A, Michienzi A. Theophylline Toxicity. Medscape Drugs & Diseases. Updated 8/31/2020. Available at https://authoring.medscape.com/content/818847.
Kerns AF, Scheffel ET, Farah R, Holstege CP. Black Widow Spider Exposures: A Retrospective Review of the National Poison Data System 2012-2022. Wilderness Environ Med. 2024 Dec 13:10806032241300134. doi: 10.1177/10806032241300134. Epub ahead of print. PMID: 39670790.
Farah R, Cole RJ, Holstege CP. Increasing severity of medical outcomes and associated substances in cases reported to United States poison centers. Clin Toxicol (Phila). 2024 Apr 18:1-8. doi: 10.1080/15563650.2024.2337897. Epub ahead of print. PMID: 38634480.
Farah R, Kerns AF, Murray AC, Holstege CP. Psilocybin Exposures Reported to US Poison Centers: National Trends Over a Decade. J Adolesc Health. 2024 Feb 26:S1054-139X(24)00063-6. doi: 10.1016/j.jadohealth.2024.01.027. Epub ahead of print. PMID: 38416101.
Moore CJ, Holstege CP, Papin JA. Metabolic modeling of sex-specific tissue predicts mechanisms of differences in toxicological responses. bioRxiv [Preprint]. 2023 Feb 7:2023.02.07.527430. doi: 10.1101/2023.02.07.527430. PMID: 36798158; PMCID: PMC9934589.
Hayden ME, Burns L, Farquhar S, Tanabe KO, Bernheim RG, Holstege CP. Using an Exposure Call Center to Help Mitigate Outbreaks, Such as COVID-19, on a University Campus. J Public Health Manag Pract. 2023 Apr 21. doi: 10.1097/PHH.0000000000001750. Epub ahead of print. PMID: 37097205.
Farah R, Rege SV, Cole RJ, Holstege CP. Suspected Suicide Attempts by Self-Poisoning Among Persons Aged 10-19 Years During the COVID-19 Pandemic – United States, 2020-2022. MMWR Morb Mortal Wkly Rep. 2023 Apr 21;72(16):426-430. doi: 10.15585/mmwr.mm7216a3. PMID: 37079475; PMCID: PMC10121270.