Vanessa Smith, M.D.

Assistant Professor of Pathology

Education:

Medical School: University of Illinois College of Medicine at Peoria, 2013-2017, M.D.
Residency: Anatomic and Clinical Pathology, Duke University Medical Center, 2017-2021
Fellowship: Molecular Genetic Pathology, Duke University Medical Center, 2023-2024
Fellowship: Neuropathology, Duke University Medical Center, 2021-2023

Clinical:

Molecular Pathology, Neuropathology

Research:

Analysis of genetic events in human cancers and in neuropathology, including muscle disorders, neurodegeneration, and epilepsy.

References:

Farhan R, Hashmi SA, Kapur J, D’Abreu A, Punia V, Manning C, Smith VL, Zawar I. Exploring biomarkers of neurodegeneration in epilepsy: Critical insights. Epileptic Disord. 2025 Apr 8. PMID: 40197800. Epub 2025 Apr 8
Mondia MWL, Hooks RE, Maragkos GA, Smith VL, McCord MR, Donahue JH, Williams ES, Lopes MB, Schiff D, Asthagiri AR. Primary diffuse leptomeningeal glioblastoma: a case report and literature review. J Neurooncol. 2025 Mar;172(1):265-272. PMID: 39666263. Epub 2024 Dec 12
Tsuchiya KD, Funke B, Hegde M, Santani A, Souers RJ, Szelinger S, Halley J, Zhao Q, Mot N, Roy A, Smith VL, Zhang BM, Voelkerding K, Moyer AM. Implementation, Evolution, and Laboratory Performance of Methods-Based Proficiency Testing for Next-Generation Sequencing Detection of Germline Sequence Variants. Arch Pathol Lab Med. 2024 Jul 1;148(7):775-783. PMID: 37852169
Liu M, Ji Z, Jain V, Smith VL, Hocke E, Patel AP, McLendon RE, Ashley DM, Gregory SG, López GY. Spatial transcriptomics reveals segregation of tumor cell states in glioblastoma and marked immunosuppression within the perinecrotic niche. Acta Neuropathol Commun. 2024 Apr 22;12(1):64. PMID: 38650010. Epub 2024 Apr 22
Fetcko-Fayad K, Batich K, Reitman ZJ, Walsh KM, Chamberlin G, Smith V, Jones K, Cummings T, Peters KB. Coexisting Biopsy-Diagnosed Dementia and Glioblastoma. Brain Sci. 2024 Jan 30;14(2):143. PMID: 38391718. Epub 2024 Jan 30
Charles AJ, Smith VL, Goodwin CR, Johnson MO. An adult with recurrent atypical teratoid rhabdoid tumor of the spine. CNS Oncol. 2024 Jan 1;13(1):CNS105. PMID: 38380555. Epub 2024 Feb 21
Dymm B, Wiggins W, Smith VL, El Husseini N, Pawar S, Feng W. Teaching NeuroImage: Diffuse Midline Glioma Mimicking Edema in Cerebral Venous Thrombosis. Neurology. 2023 Nov 7;101(19):e1945-e1947. PMID: 37652698. Epub 2023 Aug 31
Smith VL, Harrison WT. Three-year-old with severe-combined immunodeficiency and a mildly expansile T2/FLAIR signal abnormality. Brain Pathol. 2023 Nov;33(6):e13173. PMID: 37276349. Epub 2023 Jun 5
Smith VL, Wang SJ. A 68-year-old man with gait instability and T2 signal abnormality in the cerebellar peduncles. Brain Pathol. 2023 Sep;33(5):e13172. PMID: 37285581. Epub 2023 Jun 7
Alpert L, Al-Sabti R, Graham RP, Pai RK, Gonzalez RS, Zhang X, Smith V, Wang HL, Westbrook L, Goldblum JR, Bakhshwin A, Shetty S, Klimstra DS, Shia J, Askan G, Robert ME, Thomas C, Frankel WL, Alsomali M, Hagen C, Mostafa ME, Feely MM, Assarzadegan N, Misdraji J, Shih AR, Agostini-Vulaj D, Meis JM, Tang S, Chatterjee D, Kang LI, Hart J, Lee SM, Smith T, Yantiss RK, Hissong EM, Gao ZH, Wu J, Resnick MB, Wu EY, Pai RK, Zhao L, Doyle LA, Chopra S, Panarelli NC, Hu S, Longacre TA, Raghavan SS, Lauwers GY, Ghayouri M, Cooper HS, Nagarathinam R, Bellizzi AM, Kakar S, Hosseini M, Rong J, Greenson JK, Lamps LW, Dong Z, Bronner MP. Smooth muscle tumors of the gastrointestinal tract: an analysis of prognostic features in 407 cases. Mod Pathol. 2020 Jul;33(7):1410-1419. PMID: 32051556. Epub 2020 Feb 12
Smith, VL, Bentley, RC, Morse, MA, Pendse, AA. (2020). Unique presentation of a gastrointestinal stromal tumor, epithelioid type, with a dual copy loss of SDHA gene as a liver primary. Human Pathology: Case Reports 22. https://doi.org/10.1016/j.ehpc.2020.200427.
Smith V, MacMahon P, Avellino A, Lin J. Commentary: The Dilemma of Papilledema in Chiari I Malformation. Neurosurgery. 2018 Mar 1;82(3):E73-E74. PMID: 29272471
Ariki NK, Muñoz LE, Armitage EL, Goodstein FR, George KG, Smith VL, Vetter I, Herzig V, King GF, Loening NM. Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica. PLoS One. 2016;11(5):e0156291. PMID: 27227898. Epub 2016 May 26
McCormick AL, Smith VL, Chow D, Mocarski ES. Disruption of mitochondrial networks by the human cytomegalovirus UL37 gene product viral mitochondrion-localized inhibitor of apoptosis. J Virol. 2003 Jan;77(1):631-641. PMID: 12477866