Ana Karina de Oliveira, Ph.D.

Assistant Professor of Pathology
Director of Spatial Biology Core
Office of Research Core Administration


Master’s degree: University of Sao Paulo (Biotechnology), Sao Paulo, Brazil
Ph.D.: University of Sao Paulo (Biochemistry), Sao Paulo, Brazil
Postdoctoral Fellow: Brazilian Biosciences National Laboratory, LNBio (Immuno-oncology), Campinas, Brazil
Postdoctoral Fellow: University of Virginia, Stem Cell Core, Charlottesville, VA

Research Interest:

My research interest focuses on studying the molecular mechanisms involved in immune evasion, cancer development (Breast Precancer Lesion), and progression, using in vitro and in vivo models. My long-term career aspirations focus on finding new molecular targets for breast cancer therapeutic prevention.

Research References:

  1. Ramos, RN, Amano, MT, Paes Leme, AF, Fox, JW, Oliveira, AK. 2022. Editorial: Tumor Microenvironment (TME) and Tumor Immune Microenvironment (TIME): New Perspectives for Prognosis and Therapy. Front. Cell Dev. Biol. – Molecular and Cellular Pathology.
  2. Busso-Lopes, AF, Carnielli, CM, Winck, FV, Patroni, FMS, Oliveira, AK, Granato, DC, Costa, RAP, Domingues, RR, Pauletti, BA, Riaño-Pachón, DM, Aricetti, J, Caldana, C, Graner, E, Della Coletta, R, Dryden, K, Fox, JW, Paes Leme, AF. 2021. A reductionist approach using primary and metastatic cell-derived extracellular vesicles reveals hub proteins associated with oral cancer prognosis. Molecular & Cellular Proteomics, v. 20, 100118.
  3. Sá, JO, Trino, LD, Oliveira, AK, Lopes, Ariane, FBL, Granato, DC, Normando, AGC, Santos, ES, Neves, LX, Carnielli, CM, Paes Leme, AF. 2021. Proteomic approaches to assist in diagnosis and prognosis of oral cancer. Expert Review of Proteomics, v. 18, p. 261-284.
  4. Ferreira, AK, Cristofaro, B, Menezes, MC, de Oliveira, AK, Tashima, AK, de Melo, RL, Silva, CCF, Rodriguez, MGP, Carvalho, DCOS, de Azevedo, RA, Junior, PLS, Mambelli, LI, Portaro, FV, Pardanaud, L, Eichmann, A, Sant’Anna, OA, Faria. 2020. M. Alphastatin-C a new inhibitor of endothelial cell activation is a pro-arteriogenic agent in vivo and retards B16-F10 melanoma growth in a preclinical model. Oncotarget, v. 11(51), p. 4770-4787.
  5. Zelanis, A, Oliveira, AK, Prudova, A, Huesgen, PF, Tashima, AK, Kizhakkedathu, J, Overall, CM, Serrano, SMT. 2019. Deep profiling of the cleavage specificity and human substrates of snake venom metalloprotease HF3 by PICS using proteome derived peptide libraries and TAILS N-terminomics. Journal of Proteome Research, v. 18, p. 3419-3428.
  6. Oliveira, AK, Patente, TA, Ramos, RN, Lopes, Busso-Lopes, A, Domingues, RR, Amano, MT, Marengo, EB, Barbuto, JA, Paes Leme, AF. 2019. Abstract 2800: Oral cancer cell-derived extracellular vesicles can modulate an immunosuppressive microenvironment through M2 phenotype polarization. Cancer Research, v. 79. p. 2800-2800.
  7. Rivera, C; Oliveira, AK, Costa, RAP, De Rossi, T, Paes Leme, AF. 2017. Prognostic biomarkers in oral squamous cell carcinoma: A systematic review. Oral Oncology, 72, 38-47.
  8. Oliveira, AK, Paes Leme, AF, Asega, AF, Camargo, ACM, Fox, JW, Serrano, SMT. 2010. New insights into the structural elements involved in the skin haemorrhage induced by snake venom metalloproteinases. Thrombosis and Haemostasis, 104(3):485-497.
  9. Paes Leme, AF, Escalante, T, Pereira, JGC, Oliveira, AK, Sanchez, EF, Gutiérrez, JM, Serrano, SMT, Fox, JW. 2010. High resolution analysis of snake venom metalloproteinase (SVMP) peptide bond cleavage specificity using proteome based peptide libraries and mass spectrometry. Journal of Proteomics, 74(4):401-410.
  10. Oliveira, AK, Paes Leme, AF, Assakura, MT, Menezes, MC, Zelanis, A, Tashima, AK, Lopes-Ferreira, M, Lima, C, Camargo, ACM, Fox, JW, Serrano, SMT. 2009. Simplified procedures for the isolation of HF3, bothropasin, disintegrin-like/cysteine-rich protein, and a novel P-I metalloproteinase from Bothrops jararaca venom. Toxicon 53(7-8):797-801.