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Department of Pathology

Helen P. Cathro, M.B.Ch.B., M.P.H.


Professor of Pathology

CONTACT INFORMATION:

Telephone: (434) 243-0873
Email: hpc4f@virginia.edu

EDUCATION:

Medical School: University of Dundee, Scotland – MBChB (MD equivalent)
Graduate School: University of North Carolina at Chapel Hill –  MA, Public Health (Health Policy and Administration), 1993
Internships: Kingscross Hospital, Dundee, Scotland – Infectious Disease and Respiratory Medicine intern (6 mos. 1984)
Royal Cornwall Hospital, Truro, England – General Surgery intern (6 mos. 1985)
Residency: University of Virginia, School of Medicine, Charlottesville, VA. 1997 – 2001
Fellowships: Division of Renal Pathology, University of North Carolina at Chapel Hill 4 month fellowship 2002
University of Virginia, School of Medicine, Charlottesville, VA. Fellow in Cytopathology 2001-2002
Duke University, Durham , NC – Fellow in Anatomic Pathology 1985-1986
Armed Forces Institute of Pathology – Fellow in Cytopathology October 1999

CLINICAL:

Renal pathology, Transplant Pathology and Genitourinary Pathology

RESEARCH:

Translational research on native kidney disease, renal allograft pathology and renal carcinoma; other recent projects have involved work on a variety of topics including mesothelioma, pseudosarcomatous skin lesions and HPV genotyping of cervical infections in a Central American population.

REFERENCES:

  • Rhone E, Walker PD, Dumur CI, Almenara J, Cathro H, Maluf D, Mas V*. An integrated transcriptomic approach to identify molecular markers of calcineurin inhibitor nephrotoxicity in pediatric kidney transplant recipients.  Intern J Molec Sci.  [In press.]  IF 4.556. Performed pathologic analyses.
  • Scindia Y, Wlazlo E, Ghais E, Cekova S, Loi V, Leeds J, Cathro H, Swaminathan S*. Modulation of iron homeostasis with hepcidin ameliorates spontaneous murine lupus nephritis. Kid Intern. 2020; 98(1): 100-105.  Published online February 18. IF 8.395. Performed pathologic analysis.
  • Charlton JR*, Yanze X, Wu T, DeRonde KA, Hughes JL, Dutta S, Oxley GT, Cwiek A, Cathro HP, Charlton NP, Conaway MR, Baldelomar EJ, Parvin N, Bennett KM. Magnetic resonance imaging accurately tracks kidney pathology and heterogeneity in the transition from acute kidney injury to chronic kidney disease.  Kid Intern. 2021; 99(1): 173-185.  IF 8.395. Performed pathologic analysis.
  • Charlton JR*, Baldelomar EJ, deRonde K, Cathro HP, Charlton NP, Criswell S, Hyatt, D, Nam, S, Pearl V, and Bennett, KM. Nephron loss detected by MRI following neonatal acute kidney injury in rabbits.  Pediatr Res. 2020; 87(7): 1185-1192.  IF 2.88. Performed the histopathologic evaluation of the rabbit kidneys.
  • Lobo J, Clements MB, Bitner D, Noona S, Sultan M, Mikula M, Cathro
  • HP, Lambert D, Schenkman NS and Krupski TL*. Does renal mass biopsy influence multidisciplinary treatment recommendations? J Scand Urol. 2020; 54(1):27-32. IF 1.25. Helped with data analysis and edited the manuscript.
  • Cathro HP*. Iatrogenic disease of the genitourinary tract. Adv Anat Pathol 2019; 26(3): 171-185.  IF 2.358.  Ranked 33rd of 79 pathology journals.
  • Cathro HP*, Shen SS and Truong LD. Diagnostic histochemistry in medical diseases of the kidney. Sem Diag Pathol 2018; 35(6): 353-406.  IF 2.655.  Ranked 25th of 79 pathology journals.
  • Ju JY, Mills AM, Mahadevan MS, Fan J, Culp SH, Thomas MH, Cathro HP*. Universal Lynch syndrome screening should be performed in all upper tract urothelial carcinomas.  Am J Surg Pathol 2018; 42(11): 1549-1555.  IF 5.878.  Ranked 8th of 79 pathology journals.  Urology collaboration.
  • Elements MB, Schmidt KM, Canfield SE, Gilbert SM, Khandelwal SR, Koontz BF, Lallas CD, Liauw S, Nguyen P, Showalter TN, Trabulsi EJ, Cathro HP, Schenkman N, Krupski TL*. Creation of a novel digital rectal instrument to teach and assess prostate examination proficiency J Surg Educ 2018; 75(2): 431-441.  IF 2.16. Reviewed pathology to correlate with findings on clinical examination.  Urology collaboration.
  • Mills A*, Gradecki SE, Moskaluk CA, Horton BJ, Blackwell R, Mandell JW, Mills SE, Cathro HP. Diagnostic efficiency in digital pathology: a comparison of optical vs. digital assessment in 500 surgical pathology cases.  Am J Surg Pathol 2018: 42(1).  Cited 6 times. IF 5.878.  Ranked 8th of 79 pathology journals.
  • Mukhopadhyay S*, Feldman M, Abels E, Ashfaq R, Beltaifa S, Cacciabeve N, Cathro H, Cheng L, Cooper K, Dickey G, Gill R, Heaton R, Kerstens R, Lindberg G, Malhotra R, Mandell J, Manlucu E, Mills A, Mills S, Moskaluk C, Nelis M, Patil D, Przybycin C, Reynolds J, Rubin B, Saboorian M, Salicru M, Samols M, Sturgis C, Turner K, Wick M, Yoon J, Zhao P, Taylor C. Whole slide imaging versus microscopy for primary diagnosis in surgical   pathology: A multicenter blinded randomized noninferiority study of 1992 cases (pivotal study).  Am J Surg Pathol 2018; 42(1).  Cited 24 times. IF 5.878.  Ranked 8th of 79 pathology journals. Study pathologist for UVA section of study.
  • Osuru HP, Pramoonjago P, Abhyankar MM, Swanson E, Roker LA, Cathro HP, Reddi PP*. Immunolocalization of TAR DNA-binding protein of 43 kDa (TDP-43) in mouse seminiferous epithelium.  Molec Reprod and Develop 2017; 84(8).  IF 3.31.  Cited once.  Ranked 8th of 42 developmental biology journals. Provided pathologic images.
  • Gehrau RC, Mas VR, Dumur CI, Suh JL, Sharma AK, Cathro HP, Maluf DG*. Donor hepatic steatosis induce exacerbated ischemia-reperfusion injury through activation of innate immune response molecular pathways. 2015; 99(12); 2523-2533.  Cited 21 times.  IF 3.96.  Ranked 7th of 25 transplantation journals.  Reviewed pathology.
  • Cathro HP, Kowalik CG, Jensen D, Culp SH, Steers WD, Krupski TL: Lower urinary tract symptom improvement after radical prostatectomy correlates with degree of prostatic inflammation. Urology 2014, 83:186-190. http://www.ncbi.nlm.nih.gov/pubmed/24246320. DOI: 10.1016/j.urology.2013.07.080.
  • Cathro HP, Bullock GC, Bonatti H, Meriden Z, Cook S, Aguilera N: Post-transplant lymphoproliferative disorders are not associated with IgG4 sclerosing disease. Transpl Infect Dis 2014, 16:897-903.http://www.ncbi.nlm.nih.gov/pubmed/25298125. DOI: 10.1111/tid.12300.
  • Cathro HP, Legallo RD, LaFortune KA, Chikwava KR, Faria P, Geller JI, Dome JS, Mullen EA, Gratias EJ, Dehner LP, Hill DA: DICER1 mutations in childhood cystic nephroma and its relationship to DICER1-renal sarcoma. Mod Pathol 2014, 27:1267-1280. http://www.ncbi.nlm.nih.gov/pubmed/24481001. DOI: 10.1038/modpathol.2013.242.
  • Cathro HP, King AL, Gallon L, Brayman KL, Mas VR: Evaluation of molecular profiles in calcineurin inhibitor toxicity post-kidney transplant: input to chronic allograft dysfunction. Am J Transplant 2014, 14:1152-1163. http://www.ncbi.nlm.nih.gov/pubmed/24698514. DOI: 10.1111/ajt.12696.
  • Cathro H, Lee JK, Gehrau RC, Brayman KL, Gallon L, Mas VR: The urine microRNA profile may help monitor post-transplant renal graft function. Kidney Int 2014, 85:439-449. http://www.ncbi.nlm.nih.gov/pubmed/24025639. DOI: 10.1038/ki.2013.338.
  • Cathro HP: Lymphoepithelioma-like carcinoma of the penis: association with human papilloma virus infection. Histopathology 2014, 64:312-315.http://www.ncbi.nlm.nih.gov/pubmed/24117963. DOI: 10.1111/his.12248.
  • Cathro HP: Histologic and immunohistochemical assessment of penile carcinomas in a North American population. Am J Surg Pathol 2014, 38:1340-1348.http://www.ncbi.nlm.nih.gov/pubmed/25210933. DOI: 10.1097/PAS.0000000000000124.
  • Cathro HP, Cook SL, McCartney CR, Weiss GR: Doege-Potter syndrome presenting with hypoinsulinemic hypoglycemia in a patient with a malignant extrapleural solitary fibrous tumor: a case report. J Med Case Rep 2013, 7:11. http://www.ncbi.nlm.nih.gov/pubmed/23302323. DOI: 10.1186/1752-1947-7-11.
  • Cathro HP, Gaskin F, Fu SM: Cgnz1 allele confers kidney resistance to damage preventing progression of immune complex-mediated acute lupus glomerulonephritis. J Exp Med 2013, 210:2387-2401. http://www.ncbi.nlm.nih.gov/pubmed/24101379. DOI: 10.1084/jem.20130731.
  • Cathro HP: Analysis of immunohistochemical stain usage in different pathology practice settings. Am J Clin Pathol 2012, 138:831-836. http://www.ncbi.nlm.nih.gov/pubmed/23161717. DOI: 10.1309/AJCPAGVTCKDXKK0X.
  • Cathro HP: Weber-Christian disease associated with the tip variant of focal segmental glomerulosclerosis: a case report. Ultrastruct Pathol 2012, 36:415-418.http://www.ncbi.nlm.nih.gov/pubmed/23216240. DOI: 10.3109/01913123.2012.736459.
  • Cathro H, Bhola V, Ballenger FJ, Rosner MH: Proteinuria in a patient with diabetes. Kidney Int 2011, 79:793-794. http://www.ncbi.nlm.nih.gov/pubmed/21403657. DOI: 10.1038/ki.2010.549.

BOOK CHAPTERS:

  • Cohen SD, Kopp JB, Cathro HP, and Kimmel PL (Kimmel PL and Rosenberg ME, Eds). Human Immunodeficiency Virus Infection and Chronic Kidney Disease.  Chronic Renal Disease.  Elsevier, Philadelphia, PA, 2nd Edition.  To be published 1st September 2019.
  • Cathro HP (Chetty R and Wick R, Eds). Infections of the Kidney. Pathology Atlas of Infectious Diseases.  Cambridge University Press.  In press.
  • Cathro HP (Chetty R and Wick R, Eds). Infections of the Urinary Tract. Pathology Atlas of Infectious Diseases.  Cambridge University Press.  In press.
  • Cohen SD, Kopp JB, Cathro HP, and Kimmel PL (Kimmel PL and Rosenberg ME, Eds). Human Immunodeficiency Virus Infection and Chronic Kidney Disease.  Chronic Renal Disease.  Elsevier, Philadelphia, PA, 2014.
  • Mobasheri A, Cathro HP, Cobb MA, German A, Slater K, Mian S, Marples D, Martin-Vasallo P and Canessa CM (Thongboonker, Ed). Applications of Tissue Microarrays in Renal Physiology and Pathology: Combining Tissue Arrays and Proteomics to Identify and Validate Renal and Urinary Biomarkers. Renal and Urinary Proteomics: Methods and Protocols.  Wiley, VCH, Chichester, West Sussex, 2009.
  • Weiss M, Cathro HP, and Mills SE  (Wick MR, Ed).  Diagnostic Histochemistry of the Male Genital System.  Diagnostic Histochemistry. Cambridge Press, New York, NY, 2008.
  • Cathro HP, Shen SS and Truong LD (Wick MR, Ed). Diagnostic Histochemistry of Renal and Urologic Diseases.  Diagnostic Histochemistry.  Cambridge Press, New York, NY, 2008.
  • Cathro HP and Stoler MH (Hayat M, Ed). The role of cytokeratin immunohistochemistry in the differential diagnosis of ovarian tumors. Immunohistochemistry and in situ hybridization of human carcinomas.  Elsevier Science/Academic Press, Philadelphia, PA, 2004.

A current list of Dr. Cathro’s journal publications can be obtained from PubMed.

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