Thomas J. Braciale, M.D., Ph.D.
Professor of Pathology and Microbiology
Graduate School: University of Pennsylvania, Philadelphia, PA, PhD, Microbiology, 1974
Medical School: University of Pennsylvania School of Medicine, Philadelphia, PA, MD, 1975
Graduate Medical Education: Intern/Resident in Pathology, Washington University School of Medicine, St. Louis, MO, 1975-76
Postdoctoral: Visiting Fellow, Australian National University, John Curtin School of Medical Research, Canberra, Australia, 1976-78
Our research on Influenza focuses on the response of CD8+ T lymphocytes — Cytolytic T Lymphocytes (CTL) or killer T cells — to Influenza infection. We want to understand three main things: 1) how CTL are generated during infection; 2) how CD8+ T cells interact with the principal antigen presenting cells of the body (i.e. dendritic cells) to produce those CTL; and 3) how the interplay between Influenza virus and the CTL response contributes to lung injury during infection. We use modern techniques of cell and molecular biology — including T cell receptor transgenic murine models and virus reverse genetics (to alter the structure of the Influenza genome) in order to understand how specific virus genes (and their products), as well as CTL products (e.g. cytokines) operate to clear infection and/or produce disease. Recently, we have extended this work to include avian influenza virus (“Bird Flu”) infection in order to define the mechanisms of lethal infection produced by this virus.
- Hufford MM, Kim TS, Sun J, Braciale TJ: The effector T cell response to influenza infection. Curr Top Microbiol Immunol 2015, 386:423-455. http://www.ncbi.nlm.nih.gov/pubmed/25033753. DOI: 10.1007/82_2014_397.
- Steinke JW, Liu L, Turner RB, Braciale TJ, Borish L: Immune surveillance by rhinovirus-specific circulating CD4+ and CD8+ T lymphocytes. PLoS One 2015, 10:e0115271.http://www.ncbi.nlm.nih.gov/pubmed/25584821. DOI: 10.1371/journal.pone.0115271.
- Krueger PD, Kim TS, Sung SS, Braciale TJ, Hahn YS: Liver-resident CD103+ dendritic cells prime antiviral CD8+ T cells in situ. J Immunol 2015, 194:3213-3222. http://www.ncbi.nlm.nih.gov/pubmed/25712214. DOI: 10.4049/jimmunol.1402622.
- Yao S, Jiang L, Moser EK, Jewett LB, Wright J, Du J, Zhou B, Davis SD, Krupp NL, Braciale TJ, Sun J: Control of pathogenic effector T-cell activities in situ by PD-L1 expression on respiratory inflammatory dendritic cells during respiratory syncytial virus infection. Mucosal Immunol 2015, 8:746-759.http://www.ncbi.nlm.nih.gov/pubmed/25465101. DOI: 10.1038/mi.2014.106.
- Braciale T, Kim T: Influenza pathogenesis: club cells take the “cure”. J Exp Med 2014, 211:1705.http://www.ncbi.nlm.nih.gov/pubmed/25155720. DOI: 10.1084/jem.2119insight2.
- Buckley MW, Arandjelovic S, Trampont PC, Kim TS, Braciale TJ, Ravichandran KS: Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation. PLoS One 2014, 9:e105576.http://www.ncbi.nlm.nih.gov/pubmed/25153088. DOI: 10.1371/journal.pone.0105576.
- Dolina JS, Braciale TJ, Hahn YS: Liver-primed CD8+ T cells suppress antiviral adaptive immunity through galectin-9-independent T-cell immunoglobulin and mucin 3 engagement of high-mobility group box 1 in mice. Hepatology 2014, 59:1351-1365. http://www.ncbi.nlm.nih.gov/pubmed/24677194. DOI: 10.1002/hep.26938.
- Kim TS, Gorski SA, Hahn S, Murphy KM, Braciale TJ: Distinct dendritic cell subsets dictate the fate decision between effector and memory CD8(+) T cell differentiation by a CD24-dependent mechanism. Immunity 2014, 40:400-413. http://www.ncbi.nlm.nih.gov/pubmed/24631155. DOI:.1016/j.immuni.2014.02.004.
- Moser EK, Hufford MM, Braciale TJ: Late engagement of CD86 after influenza virus clearance promotes recovery in a FoxP3+ regulatory T cell dependent manner. PLoS Pathog 2014, 10:e1004315.http://www.ncbi.nlm.nih.gov/pubmed/25144228. DOI: 10.1371/journal.ppat.1004315.
- Yoo JK, Braciale TJ: IL-21 promotes late activator APC-mediated T follicular helper cell differentiation in experimental pulmonary virus infection. PLoS One 2014, 9:e105872.http://www.ncbi.nlm.nih.gov/pubmed/25251568. DOI: 10.1371/journal.pone.0105872.
- Yoo JK, Kim TS, Hufford MM, Braciale TJ: Viral infection of the lung: host response and sequelae. J Allergy Clin Immunol 2013, 132:1263-1276. http://www.ncbi.nlm.nih.gov/pubmed/23915713. DOI: 10.1016/j.jaci.2013.06.006.
A more complete list of Dr. Braciale’s publications can be obtained from PubMed