James D. Gorham, M.D., Ph.D.

James D. Gorham, M.D., Ph.D.

Chief, Division of Laboratory Medicine
Medical Director, Blood Bank & Transfusion Medicine Service
Professor of Pathology

 

EDUCATION:

Medical School: New York University, 1985 – 1992, MD PhD

Residency: Laboratory Medicine, Washington University School of Medicine / Barnes Hospital, 1992-1998

CLINICAL:

Blood Banking and Transfusion Medicine

Laboratory Medicine

RESEARCH:

Factors affecting blood storage; Immune tolerance and autoimmunity; Immunology of the liver; Mouse genetics.

SELECTED REFERENCES:

  • Martin I, Katus MC, Martin C-L B, Szczepiorkowski ZM, Gorham JD, Dunbar NM. Rapid ADAMTS13 availability impacts treatment for microangiopathic hemolytic anemia and thrombocytopenia. J of Clin Apheresis In Press.2015
  • Krishnaswamy JK, Singh A, Uthaman G, Wu R, Gorrepati P, Sales-Nacimento M, Gallman A, Liu D, Calabro S, Xu L, Raney P, Srivastava A, Gorham JD, Kleeberger S, Heinz LX, Müller AC, Bennett KL, Superti-Furga G, Cassel S, Sutterwala FS, Williams A, Flavell RA, Eisenbarth S. Coincidental loss of Dock8 function in Nlrp10-deficient and C3H/HeJ mice results in defective dendritic cell migration. Proc Natl Acad Sci (USA).112:3056-61. 2015
  • Celaj S, Gleeson MW, Deng J, O’Toole G, Hampton TH, Toft MF, Morrison HG, Sogin ML, Putra J, Suriawinata AA,Gorham JD. The microbiota regulates susceptibility to Fas-mediated acute hepatic injury. Lab Invest 94:938-49. 2014
  • Maria A, English KA, Gorham JD. Appropriate development of the liver Treg compartment is modulated by the microbiota and requires TGF-β and MyD88. J Immunol Res 2014:279736. 2014
  • Cripps JG, Wang J, Maria A, Blumenthal I, Gorham JD: Th1 cells induce the accumulation of myeloid derived suppressor cells in the inflamed Tgfb1 knockout mouse liver. Hepatology 52:1350-1359. 2010
  • Cripps JG, Celaj S, Burdick M, Strieter RM, Gorham JD: Liver inflammation in a mouse model of Th1 hepatitis despite the absence of invariant NKT cells or the Th1 chemokine receptors CXCR3 and CCR5. Lab Invest92:1461-1471. 2012
  • Gorham JD, Ranson MS, Smith JC, Gorham BJ, Muirhead K-A: 1 + 1 = 3: Development and Validation of a SNP-Based Algorithm to Identify Genetic Contributions from Three Distinct Inbred Mouse Strains. J Biomolec Techniques 23:136-146. 2012
  • Cripps JG and Gorham JD: MDSC in autoimmunity. Internat Immunopharm 11: 789-793 [Invited review].2011
  •  Manns MP, Czaja AJ, Gorham JD, Krawitt EL, Mieli-Vergani G, Vergani D, Vierling JM: Practice Guidelines: diagnosis and management of autoimmune hepatitis. Hepatology; 51:2193-2213 [American Association for the Study of Liver Disease Practice Guidelines]. 2010

BOOK CHAPTERS

·      Gorham JD: “Adaptive immunity in the liver” in Liver Immunology: Principles and Practice ME Gershwin, JM Vierling, and MP Manns, ed. (2007), Humana Press, Totowa, NJ, USA

A current list of Dr. Gorham’s journal publications can be obtained from  PubMed.