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Department of Pathology

Elizabeth Courville, M.D.

Dr. Elizabeth Courville
Associate Professor of Pathology

Medical Director, Clinical Flow Cytometry Laboratory

EDUCATION:

Medical School: Dartmouth Medical School, Hanover, NH
Residency: Massachusetts General Hospital  (Anatomic/Clinical Pathology)
Fellowship: Massachusetts General Hospital (Hematopathology)

CLINICAL:

Hematopathology

RESEARCH:

Diagnostic Hematopathology; flow cytometry

REFERENCES:

  • Xia D, Sayed S, Moloo Z, Gakinya SM, Mutuiri A, Wawire J, Okiro P, Courville EL, Hasserjian RP, Sohani AR. Geographic Variability of Nodular Lymphocyte-Predominant Hodgkin Lymphoma. Am J Clin Pathol. 2021.
  • White K, Qualtieri J, Courville EL, et al. Entrustable Professional Activities in Hematopathology Pathology Fellowship Training: Consensus Design and Proposal. Acad Pathol. 2021;8:2374289521990823.
  • Stone AB, Grzywacz BJ, Courville EL, Linden MA. Indolent B-Lineage Precursor Populations Identified by Flow Cytometry and Immunohistochemistry in Benign Lymph Nodes. Am J Clin Pathol. 2021.
  • Kleinot W, Aguilera N, Courville EL. Daratumumab Interference in Flow Cytometry Producing a False Kappa Light Chain Restriction in Plasma Cells. Lab Med. 2021;52(4):403-409.
  • Ju JY, Stelow EB, Courville EL. Normal gastrointestinal tract inflammatory cells and review of select benign hematolymphoid proliferations. Semin Diagn Pathol. 2021;38(4):6-13.
  • D’Angelo CR, Hanel W, Chen Y, Yu M, Yang D, Guo L, Karmali R, Burkar M, Ciccosanti C, David K, Risch Z, Murga-Zamalloa C, Devata S, Wilcox R, Savani M, Courville EL, Bachanova V, Rabinovich E, Peace D, Osman F, Epperla N, Kenkre VP.  Impact of initial chemotherapy regimen on outcomes for patients with double-expressor lymphoma: A multi-center analysis. Hematol          Oncol. 2021;39(4):473-482.
  • Courville EL, Shantzer L, Vitzthum von Eckstaedt HC, et al. Variant Acute Promyelocytic Leukemia Presenting Without Auer Rods Highlights the Need for Correlation with Cytogenetic Data in Leukemia Diagnosis. Lab Med. 2021.
  • Courville EL, Lawrence MG. Characteristic CD45RA/CD45RO maturation pattern by flow cytometry associated with the CD45 C77G polymorphism. Cytometry B Clin Cytom. 2021;100(5):602-605.
  • Argyris PP, Ho D, Islam MN, Khurram SA, Courville EL, et al. Self-regressing oral CD30-positive, EBV-negative, T-cell lymphoproliferative lesions. A poorly understood process highlighted by ominous clinicopathologic features and indolent behavior. Oral Surg Oral Med Oral Pathol Oral Radiol. 2021:4638.
  • Courville EL, Yohe S, Shivers P, Linden MA. VS38 Identifies Myeloma Cells With Dim CD38 Expression and Plasma Cells Following Daratumumab Therapy, Which Interferes With CD38 Detection for 4 to 6 Months. Am J Clin Pathol. 2020;153(2):221-228.
  • Rashidi A, Courville E. Massive Splenomegaly. N Engl J Med. 2019;381(6):e11.
  • Hupp M, Williams S, Dunnette B, Tessier KM, Courville EL. Comparison of evaluation techniques, including digital image analysis, for MYC protein expression by immunohistochemical stain in aggressive B-cell lymphomas. Hum Pathol. 2019;83:124-132.
  • Grzywacz B, Moench L, McKenna D, Jr., Tessier KM, Bachanova V, Cooley S, Miller JS, Courville EL. Natural Killer Cell Homing and Persistence in the Bone Marrow After Adoptive Immunotherapy Correlates With Better Leukemia Control. J Immunother. 2019;42(2):65-72.
  • Santiago V, Lazaryan A, McClune B, McKenna RW, Courville EL. Quantification of marrow hematogones following autologous stem cell transplant in adult patients with plasma cell myeloma or diffuse large B-cell lymphoma and correlation with outcome. Leuk Lymphoma. 2018;59(4):958-966.
  • Merzianu M, Groman A, Hutson A, Cotta C, Brynes RK, Orazi A, Reddy V, Teruya-Feldstein J, Amre R, Balasubramanian M, Brandao G, Cherian S, Courville E, et al. Trends in Bone Marrow Sampling and Core Biopsy Specimen Adequacy in the United States and Canada: A Multicenter Study. Am J Clin Pathol. 2018;150(5):393-405.
  • Gilles SR, Arbefeville SS, Ferrieri P, Courville EL. Lymph Node With Extensive Involvement by Cryptococcus Shortly Following Liver Transplantation. Lab Med. 2018;49(3):e78-e81.
  • Sundin A, Grzywacz BJ, Yohe S, Linden MA, Courville EL. B-cell posttransplant lymphoproliferative disorder isolated to the central nervous system is Epstein-Barr virus positive and lacks p53 and Myc expression by immunohistochemistry. Hum Pathol. 2017;61:140-147.
  • Rashidi A, Courville EL. Double-heart sign. Blood. 2017;129(23):3134.
  • Rashidi A, Courville E. Marked discordance between cytogenetic/molecular and morphologic findings in a patient with chronic myeloid leukemia. Blood Cells Mol Dis. 2017;63:32-33.
  • Gilles SR, Baughn LB, Schomaker ML, Courville EL, Nelson AC, Sachs Z. Buccal epithelial cells display somatic, bone marrow-derived CALR mutation. Blood Adv. 2017;1(25):2302-2306.
  • Dayton VJ, McKenna RW, Yohe SL, Dolan MM, Courville E, Alvarez H, Linden MA. Relapsed Acute Promyelocytic Leukemia Lacks “Classic” Leukemic Promyelocyte Morphology and Can Create Diagnostic Challenges. Am J Clin Pathol. 2017;147(1):69-76.
  • Courville EL, Griffith M, Ustun C, Yohe S, Warlick E. Impending relapse of myelodysplastic syndrome after allogeneic transplant is difficult to diagnose and requires a multi-modal approach. BMC Clin Pathol. 2017;17:28.
  • Courville EL, Crisman S, Linden MA, Yohe S. Green Neutrophilic Inclusions are Frequently Associated With Liver Injury and May Portend Short-Term Mortality in Critically Ill Patients. Lab Med. 2017;48(1):18-23.
  • Ustun C, Smith A, Cayci Z, Courville EL, et al. Allogeneic hematopoietic cell transplantation in systemic mastocytosis: is there a high risk for veno-occlusive disease? Eur J Haematol. 2016;96(6):655-657.
  • Ustun C, Courville EL, DeFor T, et al. Myeloablative, but not Reduced-Intensity, Conditioning Overcomes the Negative Effect of Flow-Cytometric Evidence of Leukemia in Acute Myeloid Leukemia. Biol Blood Marrow Transplant. 2016;22(4):669-675.
  • Ustun C, Courville EL. Resolution of osteosclerosis after alloHCT in systemic mastocytosis. Blood. 2016;127(14):1836.
  • Moench L, Sachs Z, Aasen G, Dolan M, Dayton V, Courville EL. Double- and triple-hit lymphomas can present with features suggestive of immaturity, including TdT expression, and create diagnostic challenges. Leuk Lymphoma. 2016;57(11):2626-2635.
  • Foster LA, Courville EL, Manousakis G. Clinical Reasoning: A 33-year-old man with cardiomyopathy and myopathy. Neurology. 2016;87(8):e74-78.
  • Elwir S, Thakral B, Glessing B, Courville E, Mallery S. Rare Subepithelial Mass Diagnosed as Gastric Splenosis via EUS-FNA. ACG Case Rep J. 2016;3(4):e101.
  • Courville EL, Yohe S, Chou D, et al. EBV-negative monomorphic B-cell post-transplant lymphoproliferative disorders are pathologically distinct from EBV-positive cases and frequently contain TP53 mutations. Mod Pathol. 2016;29(10):1200-1211.
  • Courville EL, Singh C, Yohe S, et al. Patients With a History of Chemotherapy and Isolated del(20q) With Minimal Myelodysplasia Have an Indolent Course. Am J Clin Pathol. 2016;145(4):459-466.
  • Ustun C, Trottier BJ, Sachs Z, DeFor TE, Shune L, Courville EL, et al. Monosomal karyotype at the time of diagnosis or transplantation predicts outcomes of allogeneic hematopoietic cell transplantation in myelodysplastic syndrome. Biol Blood Marrow Transplant. 2015;21(5):866-872.
  • Randall N, Courville EL, Baughn L, Afrin L, Ustun C. Bosutinib, a Lyn/Btk inhibiting tyrosine kinase inhibitor, is ineffective in advanced systemic mastocytosis. Am J Hematol. 2015;90(4):E74.
  • Ustun C, Cayci Z, Courville E. A patient with skin lesions, osteosclerosis and hepatosplenomegaly. Br J Haematol. 2014;167(3):291.
  • Thakral B, Courville E. Crystal-storing histiocytosis with IgD κ-associated plasma cell neoplasm. Blood. 2014;123(23):3540.
  • Liegel J, Courville E, Sachs Z, Ustun C. Use of sorafenib for post-transplant relapse in FLT3/ITD-positive acute myelogenous leukemia: maturation induction and cytotoxic effect. Haematologica. 2014;99(11):e222-224.
  • Courville EL, Sohani AR, Hasserjian RP, Zukerberg LR, Harris NL, Ferry JA. Diverse clinicopathologic features in human herpesvirus 8-associated lymphomas lead to diagnostic problems. Am J Clin Pathol. 2014;142(6):816-829.
  • Courville EL, Wu Y, Kourda J, et al. Clinicopathologic analysis of acute myeloid leukemia arising from chronic myelomonocytic leukemia. Mod Pathol. 2013;26(6):751-761.
  • Courville EL, Lew M, Sadow PM. Routine evaluation of adult tonsillectomy specimens: toward establishing a new standard of care. Int J Surg Pathol. 2011;19(4):469-475.
  • Courville EL, Siegel CA, Vay T, Wilcox AR, Suriawinata AA, Srivastava A. Isolated asymptomatic ileitis does not progress to overt Crohn disease on long-term follow-up despite features of chronicity in ileal biopsies. Am J Surg Pathol. 2009;33(9):1341-1347.

 

A current list of Dr. Courville’s peer-reviewed publications is available from PubMed.

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