Chance John Luckey, M.D., Ph.D.

Associate Medical Director

EDUCATION:

Medical School: University of Virginia, 2001
Fellowship: Transfusion Medicine, Harvard Joint Program in Transfusion Medicine ( Brigham and Women’s Hospital/Children’s Hospital of Boston/Dana Farber Cancer Center/ Massachusetts General Hospital/ Beth Isreal Deconess Hospital) 2005

RESEARCH:

Cytokine signaling and transcriptional regulation of red blood cell alloimmunization; Cytokine and transcriptional regulation of immune memory.

CLINICAL:

Cellular therapies and bone marrow transplantation. Transfusion medicine/ blood banking in both adult and pediatric settings

REFERENCES:

Farth KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RF, Shishkin AA, Hatan M, Carrasco-Alfonso M, Mayer D, Luckey, CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE: Genetics and epigenetic fine mapping of causal autoimmune disease varients. Nature 2015, 518:337-343. http://www.ncbi.nih.gov/pubmed/25363779. DOI: 10.1038/nature13825.
Lu Y, Loh YH, Li H, Cesana M, Ficarro SB, Parikh JR, Salomonis N, Toh CX, Andreadis ST, Luckey CJ, Collins JJ, Daley GQ, MArto JA: Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells. Cell Stem Cell 2014, 15:92-101. http://www.ncbi.nlm.nih.gov/pubmed/24813856 . DOI: 10.1016/j.stem.2014.04.002.
Babic AM, Jang S, Nicolov E, Voicu H, Luckey, CJ: Culture of mouse amniotic fluid-derived cells on irradiated STO feeders results in the generation of primitive endoderm cell lines capable of self-renewal in vitro. Cells Tissues Organs 2013. 198:111-126. http://www.ncbi.nlm.nih.gov/pubmed/24060676 . DOI: 10.1159/000353942.
Luckey CJ, Silverstein LE: A mouse model of hemolytic disease of the newborn. Blood 2014, 122:1334-1335. http://www.ncbi.nlm.nih.gov/pubmed/23971354 . DOI:10.1182/blood-2013-07-512715.
Quillen K, Luckey CJ: Blood and bombs: blood use after the Boston Marathon bombing of April 15, 2013. Transfusion 2014, 54:1202-1203. http://www.ncbi. DOI: 10.1111/trf.12642..nlm.gov/pubmed/24724792
Zhou F, Lu Y, Ficarro SB, Adelmant G, Jiang W, Luckey CJ, Marto JA: GEnome-scale proteome quantification by DEEP SEQ mass spectrometry. Nat Commun 2013, 4:2171. http://www.ncbi.nlm.nih.gov/pubmed/23862870 . DOI: 10.1038/ncomms3171.
Koleva RI, Ficarro SB, Radomska HS, Carrasco-Alfonso M, Alberta JA, Webber JT, Luckey CJ, Marcucci G, Tenen DG, Marto JA: C/EBPI+/- and DEK coordinately regulate myeloid differentiation. Blood 2012, 119:4878-4888. http://ncbi.nlm.nih.gov/pubmed/22474248 . DOI: 10.1182/blood-201AHou F, Lu Y, FIcarro SB, Adelmant G, Jiang W, 1-10-383083.
Luckey CJ, Lu Y, Marto JA: Understanding the first steps in embryonic stem cell exit from the pluripotent state. Transfusion 2011, 51 Suppl 4:228S-124S. http://ncbi.nlm.nih.gov/pubmed/22074622 . DOI: 10.111/j.1537-2995.2011.03374.x.
Zhang Y, ASkenazi M, Jiang J, Luckey CJ, Griffin JD, Marto JA: A robust error model for iTRAQ quantification reveals divergent signaling between oncogenic FLT3 mutants in acute myeloid leukemia. Mol Cell Proteomics 2010, 9:780-790. http://ncbi.nlm.nih.gov/pubmed/20019052. DOI: 10.1074/mcp.M900452-MCP200.
Ficarro SB, Zhang Y, Lu Y, Moghimi AR, Askenazi M, Hyatt E, Smith ED, Boyer L, Schlaeger TM, Luckey CJ, Marto JA: Improved electrospray ionization efficiency compensates for diminished Chromatographic resolution and enables proteomics analysis of tyrosine signaling in embryonic stem cells. Anal CHem 2009, 81:3440-3447. http://ncbi.nlm.nih.gov.pubmed/19331382 . DOI: 10.1021/ac802720e.
Luckey cj, Bhattacharya D, Goldrath AW, Weissman IL, Benoist C, Mathis D: Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proc Nat’l Acad Aci I S A 2006, 103:3304-3309. http://ncbi.nlm.nih.gov.pubmed/16492737 . DOI: 10.1073/pnas.0511137103.