Christopher A. Moskaluk, M.D., Ph.D.

Walter Reed Professor and Chair of Pathology
Professor of Biochemistry & Molecular Genetics

EDUCATION:

Medical School: Duke University of Medicine 1982 – 1990 MD, PhD
Residency: Anatomic Pathology. Laboratory of Pathology, National Cancer Institute of Health, Bethesda, MD. 1990 – 1993
Fellowship: Gastrointestinal Pathology. Department of Pathology, John Hopkins University School of Medicine, Baltimore, MD. 1993 – 1995

CLINICAL:

Surgical Pathology

RESEARCH:

Analysis of molecular genetic events in human cancers, including molecular changes in precursor lesions of malignant neoplasms.

REFERENCES:

Baras, A., Yu, Y., Filtz, M., Kim, B., Moskaluk, C.A. Combined genomic and gene expression microarray profiling identifies ECOP as an up-regulated gene in squamous cell carcinomas independent of DNA amplification. Oncogene advance online publication 15 June 2009; doi: 10.1038/onc.2009.150.
Hagan, K., Bienvenue, J., Moskaluk, C., Landers, J. Microchip-based solid phase purification of RNA from biological samples. Anal Chem 80:8453-60, 2008.
Yu, Y., Baras, A.S., Frierson Jr., H.F., Moskaluk, C.A. Concurrent loss of heterozygosity and copy number abnormality analysis in adenoid cystic carcinoma by SNP genotyping arrays. Lab Invest87:430-435, 2007.
Stelow, E., Reid Adams, R., Moskaluk, C. The prevalence of pancreatic intraepithelial neoplasia in pancreata with uncommon types of primary neoplasms. Am J Surg Pathol 30:36-41, 2006.
Raponi, M., Zhang, Y., Yu, J., Chen, G., Lee, G., Taylor, J. M. , Macdonald, J., Thomas, D.,Moskaluk, C., Wang, Y., Beer, D. G. Gene expression signatures for predicting prognosis of squamous cell and adenocarcinomas of the lung. Cancer Res 66: 7466-72, 2006.
Hong, S.-M., Presley, A. E., Stelow, E.B., Frierson Jr., H.F., Moskaluk, C.A. Reconsideration of the histologic definitions used in the pathological staging of extrahepatic cholangiocarcinoma. Am J Surg Pathol 30:744-9, 2006.
Rutherford, S., Yu, Y., Rumpel, C.A., Frierson Jr., H.F., Moskaluk, C.A. Chromosome 6 deletion and tumor suppressor genes in adenoid cystic carcinoma. Cancer Lett 236:309-317, 2006.
Pramoonjago, P., Baras, A.S., Moskaluk, C.A. Knockdown of Sox-4 expression by RNAi induces apoptosis in ACC3 cells. Oncogene 25:5626-5639, 2006.
Moskaluk, C.A. Vanishing prostate cancer syndrome: symptom of a larger clinical issue. Am J Surg Pathol 29:561-3, 2005.
Moskaluk, C.A. Tissue processing re-visited: A shifting paradigm in surgical pathology. Diagn Mol Pathol 14:125-6, 2005.
Rutherford, S., Hampton, G.M., Frierson Jr., H.F., Moskaluk, C.A. Mapping of candidate tumor suppressor genes on chromosome 12 in adenoid cystic carcinoma. Lab Invest 85:1076-1085, 2005.
Welsh JB. Sapinoso LM. Kern SG. Brown DA. Liu T. Bauskin AR. Ward RL. Hawkins NJ. Quinn DI. Russell PJ. Sutherland RL. Breit SN. Moskaluk CA. Frierson HF Jr. Hampton GM. Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum. Proc Natl Acad Sci USA 100:3410-5, 2003.
Phillips, R.W., Frierson, Jr., H.F., and Moskaluk, C.A. Cdx2 as a marker of epithelial intestinal differentiation in the esophagus. Am J Surg Pathol 27:1442-47, 2003.
Moskaluk, C.A., Zhang, H., Powell, S.M., Cerilli, L.A., Hampton G.M.. Frierson, Jr., H.F. Cdx2 protein expression in normal and malignant human tissues: an immunohistochemical survey using tissue microarrays. Mod Pathol 16:913-9, 2003.
Moskaluk, C.A. Standardization of clinical immunohistochemistry: Why, how and by whom? Am J Clin Pathol 118:669-671, 2002.
Patel, S., Goldstein, M., Adams, R. and Moskaluk, C.A. Genetic analysis of invasive carcinoma arising in intraductal oncocytic papillary neoplasm of pancreas. Am J Surg Pathol 26:1071-1077, 2002.
Moskaluk, C.A. and Stoler, M.H. Agarose mold embedding of cultured cells for tissue microarrays.Diagn Mol Pathol 11:234-238, 2002.
Frierson, Jr., H.F., El-Naggar, A.K., Welsh, J.B., Sapinoso, L.M., Su, A.I., Cheng, J, Saku, T,Moskaluk, C.A., and Hampton, G.M. Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma. Am J Pathol 161:1315-23, 2002.

BOOK CHAPTERS:

Moskaluk, C.A. (2004) Molecular pathology laboratory of the future. In Dissecting the Molecular Anatomy of Tissue (Emmert-Buck, Gillespie, Chuaqui, eds., Springer-Verlag, Heidelberg, Germany).
Moskaluk, C. (2003) Esophagus. In Modern Surgical Pathology 1^st Ed. (Weidner, N., et al eds.; W.B. Saunders Co., Philadelphia) pp. 631-667.
Moskaluk, C.A. (2000) Microdissection of histologic sections: Manual and Laser Capture Microdissection Techniques. In Colorectal Cancer Methods and Protocols (Humana Press, Totowa, New Jersey) pp 1-13.

A current list of Dr. Moskaluk’s peer-reviewed publications is available from PubMed.