James W. Mandell, M.D., Ph.D.

James W. Mandell, M.D.
Professor, Division of Neuropathology
Member, Neuroscience Graduate Program
Associate Director for Curriculum, Medical Scientist Training Program

EDUCATION:

Medical School: M.D./Ph.D. Cornell University Medical College, New York, NY. MD, 1992
Graduate School: Postdoctoral Fellow, Department of Neuroscience, Laboratory of Dr. Gary Banker, University of Virginia, 1992 – 1994
Residency: Anatomic Pathology, University of Virginia, 1994 – 1996
Fellowship: Fellow, Neuropathology, University of Virginia, 1996 – 1998

CLINICAL:

Clinical Interests:

Surgical and Autopsy Diagnostic Neuropathology
Neuromuscular Pathology
Ophthalmic Pathology
In addition to shared coverage of the Diagnostic Surgical and Autopsy Neuropathology service, I am the sole faculty member responsible for all neuromuscular biopsy diagnosis as well as for all ophthalmic pathology diagnosis.

RESEARCH:

Currently my research program has two funded projects. The first is focused on discovering and validating biomarkers of synaptic degeneration, using a global proteomics screening platform. The second seeks to identify novel biomarkers of inflammatory myopathies, especially inclusion body myositis, focusing on noncoding RNAs that can be detected both in muscle biopsies as well as in the circulation. We have developed a novel multiplex immunhistochemistry platform (patent application pending) that should have broad utility in anatomic pathology and seek new collaborative projects.

mandel lab

REFERENCES:

Chen CJ, Williams EA, McAneney TE, Williams BJ, Mandell JW, Shaffrey ME: Histiocytic sarcoma of the cavernous sinus: case report and literature review. Brain Tumor Pathol 2015, 32:66-71. http://www.ncbi.nlm.nih.gov/pubmed/24807104. DOI: 10.1007/s10014-014-0191-3.
Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J: Structural and functional features of central nervous system lymphatic vessels. Nature 2015, http://www.ncbi.nlm.nih.gov/pubmed/26030524. DOI: 10.1038/nature14432.
Sokolowski JD, Gamage KK, Heffron DS, Leblanc AC, Deppmann CD, Mandell JW: Caspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injury. Acta Neuropathol Commun 2014, 2:16. http://www.ncbi.nlm.nih.gov/pubmed/24507707. DOI: 10.1186/2051-5960-2-16.
Nacey NC, Almira Suarez MI, Mandell JW, Anderson MW, Gaskin CM: Intraneural perineurioma of the sciatic nerve: an under-recognized nerve neoplasm with characteristic MRI findings. Skeletal Radiol 2014, 43:375-379. http://www.ncbi.nlm.nih.gov/pubmed/24061494. DOI: 10.1007/s00256-013-1733-1.
Sokolowski JD, Chabanon-Hicks C, Han CZ, Heffron DS, Mandell JW: Fractalkine is a “find-me” signal released by neurons undergoing ethanol-induced apoptosis. Front Cell Neurosci 2014, 8:360.http://www.ncbi.nlm.nih.gov/pubmed/25426022. DOI: 10.3389/fncel.2014.00360.
Hochreiter-Hufford A, Lee CS, Kinchen JM, Sokolowski JD, Arandjelovic S, Call JA, Klibanov AL, Yan Z, Mandell JW, Ravichandran KS: Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion. Nature 2013, 497:263-267. http://www.ncbi.nlm.nih.gov/pubmed/23615608. DOI: 10.1038/nature12135.
Huang X, Zhang Y, Tang Y, Butler N, Kim J, Guessous F, Schiff D, Mandell J, Abounader R: A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy. Neoplasia 2013, 15:952-965. http://www.ncbi.nlm.nih.gov/pubmed/23908595.
Mandell J, Heffron D, Sokolowski J: Persistence Of Apoptotic Debris In Brain-Specific Rac1-Conditional Knockouts: Evidence For A Macroglial Clearance Function. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 2011, 70:528-529. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000290751700124&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=cfc784e19a5045db07524a7304ce6a05.
Sokolowski JD, Nobles SL, Heffron DS, Park D, Ravichandran KS, Mandell JW: Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: implications for its dual function as an apoptotic engulfment receptor. Brain Behav Immun 2011, 25:915-921. http://www.ncbi.nlm.nih.gov/pubmed/20888903. DOI: 10.1016/j.bbi.2010.09.021.
Louis RG, Yen CP, Mohila CA, Mandell JW, Sheehan J: A rare intraosseous arteriovenous malformation of the spine. J Neurosurg Spine 2011, 15:336-339.http://www.ncbi.nlm.nih.gov/pubmed/21663404. DOI: 10.3171/2011.5.SPINE10872.

A more complete list of Dr. Mandell’s publications can be obtained from PubMed