M. Beatriz S. Lopes, M.D., Ph.D.

Professor of Pathology
Director of Neuropathology and
Neuropathology Fellowship Program

Director of Autopsy

EDUCATION:

Medical School: University of Sao Paulo School of Medicine, December 1982, MD,

Residency: Anatomic Pathology, University of Sao Paulo School of Medicine, January 1983 – January 1986

Fellowship: Neuropathology, University of Sao Paulo School of Medicine, February 1986 – December 1988; Fellowship in Neuropathology, University of Virginia Health Sciences Center, January 1989 – December 1993

CLINICAL:

Neuropathology, Pituitary Pathology, Autopsy Pathology.

RESEARCH INTERESTS:

My research interests focus on two major areas: 1- Hypothalamic, pituitary and peripheral interactions in the pathogenesis of pituitary adenomas; 2 – Molecular mechanisms of pathogenesis and invasion of brain tumors. My current projects are: 1. Mechanisms of invasion and progression of pituitary adenomas; 2 -Refinement of the morphologic, immunohistochemical and molecular techniques for pathological classification of brain tumors; 3 – The mechanisms of glioma invasion and migration; 4 – The effects of malnutrition and specific micronutrients on intestinal, brain, and cognitive development in a murine model. Experimental techniques in our laboratory include cell culture, immunohistochemistry, immunofluorescence, and in situ hybridization.

REFERENCES:

Dallapiazza R, Khaled M, Eames M, Snell J, Lopes MB, Wintermark M, Elias WJ: Feasibility and Safety of MR-Guided Focused Ultrasound Lesioning in the Setting of Deep Brain Stimulation. Stereotact Funct Neurosurg 2015, 93:140-146. http://www.ncbi.nlm.nih.gov/pubmed/25765151. DOI: 10.1159/000368908.
Xu Z, Carlson C, Snell J, Eames M, Hananel A, Lopes MB, Raghavan P, Lee CC, Yen CP, Schlesinger D, Kassell NF, Aubry JF, Sheehan J: Intracranial inertial cavitation threshold and thermal ablation lesion creation using MRI-guided 220-kHz focused ultrasound surgery: preclinical investigation. J Neurosurg 2015, 122:152-161.http://www.ncbi.nlm.nih.gov/pubmed/25380106. DOI: 10.3171/2014.9.JNS14541.
Lee CC, Vance ML, Lopes MB, Xu Z, Chen CJ, Sheehan J: Stereotactic radiosurgery for acromegaly: outcomes by adenoma subtype. Pituitary 2015, 18:326-334. http://www.ncbi.nlm.nih.gov/pubmed/24925503. DOI: 10.1007/s11102-014-0578-5.
Lopes MB: Errors in the pathology laboratory. J Neurosurg 2015, 122:273-274.http://www.ncbi.nlm.nih.gov/pubmed/25423273. DOI: 10.3171/2014.3.JNS14459.
Kleinschmidt-DeMasters B, Lopes MB, Prayson RA: An algorithmic approach to sellar region masses. Arch Pathol Lab Med 2015, 139:356-372. http://www.ncbi.nlm.nih.gov/pubmed/25724033. DOI: 10.5858/arpa.2014-0020-OA.
Durst CR, Raghavan P, Shaffrey ME, Schiff D, Lopes MB, Sheehan JP, Tustison NJ, Patrie JT, Xin W, Elias WJ, Liu KC, Helm GA, Cupino A, Wintermark M: Multimodal MR imaging model to predict tumor infiltration in patients with gliomas. Neuroradiology 2014, 56:107-115. http://www.ncbi.nlm.nih.gov/pubmed/24337609. DOI: 10.1007/s00234-013-1308-9.
Louis DN, Perry A, Burger P, Ellison DW, Reifenberger G, von Deimling A, Aldape K, Brat D, Collins VP, Eberhart C, Figarella-Branger D, Fuller GN, Giangaspero F, Giannini C, Hawkins C, Kleihues P, Korshunov A, Kros JM,Beatriz Lopes M, Ng HK, Ohgaki H, Paulus W, Pietsch T, Rosenblum M, Rushing E, Soylemezoglu F, Wiestler O, Wesseling P, International Society ON: International Society Of Neuropathology–Haarlem consensus guidelines for nervous system tumor classification and grading. Brain Pathol 2014, 24:429-435.http://www.ncbi.nlm.nih.gov/pubmed/24990071. DOI: 10.1111/bpa.12171.
Xu Z, Ellis S, Lee CC, Starke RM, Schlesinger D, Lee Vance M, Lopes MB, Sheehan J: Silent corticotroph adenomas after stereotactic radiosurgery: a case-control study. Int J Radiat Oncol Biol Phys 2014, 90:903-910.http://www.ncbi.nlm.nih.gov/pubmed/25216855. DOI: 10.1016/j.ijrobp.2014.07.013.
Mete O, Lopes MB, Asa SL: Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. Am J Surg Pathol 2013, 37:1694-1699. http://www.ncbi.nlm.nih.gov/pubmed/23887161. DOI: 10.1097/PAS.0b013e31829723e7.
Taylor JW, Flanagan EP, O’Neill BP, Siegal T, Omuro A, Deangelis L, Baehring J, Nishikawa R, Pinto F, Chamberlain M, Hoang-Xuan K, Gonzalez-Aguilar A, Batchelor T, Blay JY, Korfel A, Betensky RA, Lopes MB, Schiff D: Primary leptomeningeal lymphoma: International Primary CNS Lymphoma Collaborative Group report. Neurology 2013, 81:1690-1696. http://www.ncbi.nlm.nih.gov/pubmed/24107866. DOI: 10.1212/01.wnl.0000435302.02895.f3.

BOOK CHAPTERS:

Lopes MBS, Pernicone PJ, Scheithauer BW, Horvath E, Kovacs K (2007) Pituitary and Sellar Region. In: Histology for Pathologists, 3rd Edition (Mills SE, Ed.), Lippincott Williams & Wilkins, Baltimore, pp. 321-345.

Lopes MBS, VandenBerg SR (2007) Tumors of the Central Nervous System. In: Diagnostic Histopathology of Tumors, 3rd Edition (Fletcher CDM, Ed.). Churchill Livingstone, London, pp. 1653-1732.

Lopes MBS (2007) Tumors of the Pituitary Gland. In: Diagnostic Histopathology of Tumors, 3rd Ed (Fletcher CDM, Ed.). Churchill Livingstone, London, pp. 971-996.

Lopes MBS, Thapar K, Horvath E, Kovacs K. (2006) Neoplasms of the Sellar Region. In: Russell and Rubinstein’s Pathology of Tumors of the Nervous System (McLendon RE, Rosenblum MK & Bigner DD, Eds). Hodder Arnold, London, pp. 663-764.

Lopes MBS (2005) Neuropathology. In: Principles of Neuro-Oncology (Schiff D, O’Neill B, Eds). McGraw Hill, New York, pp. 81-119.

Lopes MBS, Scheithauer BW, Saeger W (2004) Granular Cell Tumor. In: WHO Classification of Tumours, Pathology and Genetic of Tumours of Endocrine Organs.(DeLellis RA, Lloyd RV, Heitz PU, Eng C, Eds.). IARC Press, Lyon, France, pp.44-45.

Lopes MBS, Scheithauer BW, Saeger W (2004) Mesenchymal tumours of the pituitary region. In: WHO Classification of Tumours, Pathology and Genetic of Tumours of Endocrine Organs. (DeLellis RA, Lloyd RV, Heitz PU, Eng C, Eds.). IARC Press, Lyon, France, pp.41-43.

A more complete list of Dr. Lopes’ publications can be obtained from PubMed.