M. Beatriz S. Lopes, M.D., Ph.D.
Professor of Pathology
Director of Neuropathology and Neuropathology Fellowship Program
Director of Autopsy
EDUCATION:
Medical School: University of Sao Paulo School of Medicine, December 1982, MD,
Residency: Anatomic Pathology, University of Sao Paulo School of Medicine, January 1983 – January 1986
Fellowship: Neuropathology, University of Sao Paulo School of Medicine, February 1986 – December 1988; Fellowship in Neuropathology, University of Virginia Health Sciences Center, January 1989 – December 1993
CLINICAL:
Neuropathology, Pituitary Pathology, Autopsy Pathology.
RESEARCH INTERESTS:
My research interests focus on two major areas: 1- Hypothalamic, pituitary and peripheral interactions in the pathogenesis of pituitary adenomas; 2 – Molecular mechanisms of pathogenesis and invasion of brain tumors. My current projects are: 1. Mechanisms of invasion and progression of pituitary adenomas; 2 -Refinement of the morphologic, immunohistochemical and molecular techniques for pathological classification of brain tumors; 3 – The mechanisms of glioma invasion and migration; 4 – The effects of malnutrition and specific micronutrients on intestinal, brain, and cognitive development in a murine model. Experimental techniques in our laboratory include cell culture, immunohistochemistry, immunofluorescence, and in situ hybridization.
REFERENCES:
- Dallapiazza R, Khaled M, Eames M, Snell J, Lopes MB, Wintermark M, Elias WJ: Feasibility and Safety of MR-Guided Focused Ultrasound Lesioning in the Setting of Deep Brain Stimulation. Stereotact Funct Neurosurg 2015, 93:140-146. http://www.ncbi.nlm.nih.gov/pubmed/25765151. DOI: 10.1159/000368908.
- Xu Z, Carlson C, Snell J, Eames M, Hananel A, Lopes MB, Raghavan P, Lee CC, Yen CP, Schlesinger D, Kassell NF, Aubry JF, Sheehan J: Intracranial inertial cavitation threshold and thermal ablation lesion creation using MRI-guided 220-kHz focused ultrasound surgery: preclinical investigation. J Neurosurg 2015, 122:152-161.http://www.ncbi.nlm.nih.gov/pubmed/25380106. DOI: 10.3171/2014.9.JNS14541.
- Lee CC, Vance ML, Lopes MB, Xu Z, Chen CJ, Sheehan J: Stereotactic radiosurgery for acromegaly: outcomes by adenoma subtype. Pituitary 2015, 18:326-334. http://www.ncbi.nlm.nih.gov/pubmed/24925503. DOI: 10.1007/s11102-014-0578-5.
- Lopes MB: Errors in the pathology laboratory. J Neurosurg 2015, 122:273-274.http://www.ncbi.nlm.nih.gov/pubmed/25423273. DOI: 10.3171/2014.3.JNS14459.
- Kleinschmidt-DeMasters B, Lopes MB, Prayson RA: An algorithmic approach to sellar region masses. Arch Pathol Lab Med 2015, 139:356-372. http://www.ncbi.nlm.nih.gov/pubmed/25724033. DOI: 10.5858/arpa.2014-0020-OA.
- Durst CR, Raghavan P, Shaffrey ME, Schiff D, Lopes MB, Sheehan JP, Tustison NJ, Patrie JT, Xin W, Elias WJ, Liu KC, Helm GA, Cupino A, Wintermark M: Multimodal MR imaging model to predict tumor infiltration in patients with gliomas. Neuroradiology 2014, 56:107-115. http://www.ncbi.nlm.nih.gov/pubmed/24337609. DOI: 10.1007/s00234-013-1308-9.
- Louis DN, Perry A, Burger P, Ellison DW, Reifenberger G, von Deimling A, Aldape K, Brat D, Collins VP, Eberhart C, Figarella-Branger D, Fuller GN, Giangaspero F, Giannini C, Hawkins C, Kleihues P, Korshunov A, Kros JM,Beatriz Lopes M, Ng HK, Ohgaki H, Paulus W, Pietsch T, Rosenblum M, Rushing E, Soylemezoglu F, Wiestler O, Wesseling P, International Society ON: International Society Of Neuropathology–Haarlem consensus guidelines for nervous system tumor classification and grading. Brain Pathol 2014, 24:429-435.http://www.ncbi.nlm.nih.gov/pubmed/24990071. DOI: 10.1111/bpa.12171.
- Xu Z, Ellis S, Lee CC, Starke RM, Schlesinger D, Lee Vance M, Lopes MB, Sheehan J: Silent corticotroph adenomas after stereotactic radiosurgery: a case-control study. Int J Radiat Oncol Biol Phys 2014, 90:903-910.http://www.ncbi.nlm.nih.gov/pubmed/25216855. DOI: 10.1016/j.ijrobp.2014.07.013.
- Mete O, Lopes MB, Asa SL: Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. Am J Surg Pathol 2013, 37:1694-1699. http://www.ncbi.nlm.nih.gov/pubmed/23887161. DOI: 10.1097/PAS.0b013e31829723e7.
- Taylor JW, Flanagan EP, O’Neill BP, Siegal T, Omuro A, Deangelis L, Baehring J, Nishikawa R, Pinto F, Chamberlain M, Hoang-Xuan K, Gonzalez-Aguilar A, Batchelor T, Blay JY, Korfel A, Betensky RA, Lopes MB, Schiff D: Primary leptomeningeal lymphoma: International Primary CNS Lymphoma Collaborative Group report. Neurology 2013, 81:1690-1696. http://www.ncbi.nlm.nih.gov/pubmed/24107866. DOI: 10.1212/01.wnl.0000435302.02895.f3.
BOOK CHAPTERS:
A more complete list of Dr. Lopes’ publications can be obtained from PubMed.