Trinh, Bon Q
Tenure-track Assistant Professor, Pathology
- PhD, Biomedical Sciences, University of Texas Graduate School of Biomedical Sciences
Biochemistry, Bioinformatics and Genomics, Cancer Biology, Cell and Developmental Biology, Computational Biology, Development, Epigenetics, Experimental Pathology, Genetics, Molecular Biology, Molecular Pharmacology, Translational Science
Understanding Protein and RNA regulations of gene expression via chromatin structure in myeloid cell development and diseases
Myeloid cells, including granulocytes and macrophages, play a crucial role in the body's defense against infections. Abnormalities in their functions and maturation cause various diseases. At the Trinh laboratory, we employ experimental and computational approaches to understand how proteins and RNAs act at chromatin level to control activities of key genes involved in normal myeloid cell maturation, leukemia development, myeloid cell - cancer cell communication in the tumor microenvironment, as well as drug response. The aims are to identify actionable molecular targets and diagnostic biomarkers, and to develop innovative therapeutic strategies for diseases such as cancer.